- Lixisenatide for type 2 diabetes mellitus
[作者:Christensen, M; Knop, FK; Vilsboll, T; Holst, JJ,期刊:Expert opinion on investigational drugs, 页码:549-557 , 文章类型: Article,,卷期:2011年20-4]
- Areas covered: Pharmacological, preclinical and clinical evidence demonstrating the applicability of lixisenatide for the treatment of T2DM are reviewed. Available data and pending clinical development are summarized, cr...
- S/GSK1349572, a new integrase inhibitor for the treatment of HIV: promises and challenges
[作者:Lenz, JCC; Rockstroh, JK,期刊:Expert opinion on investigational drugs, 页码:537-548 , 文章类型: Article,,卷期:2011年20-4]
- Areas covered: A Pubmed and Medline search was carried out on all articles on S/GSK1349572 from 2005 to 2010, including recent abstract presentations from major HIV conferences (CROI 2010, WAC2010, EACS2009, HIV10 and IC...
- Epigenetic regulation in myelodysplastic syndromes: implications for therapy
[作者:Vigna, E; Recchia, AG; Madeo, A; Gentile, M; Bossio, S; Mazzone, C; Lucia, E; Morabito, L; Gigliotti, V; De Stefano, L; Caruso, N; Servillo, P; Franzese, S; Fimognari, F; Bisconte, MG; Gentile, C; Morabito, F,期刊:Expert opinion on investigational drugs, 页码:465-493 , 文章类型: Review,,卷期:2011年20-4]
- Areas covered: This review provides an understanding of studies investigating novel agents published up to January 2011 aimed at normalizing and monitoring the epigenetic profile of the MDS cancer cell. The authors discu...
- Riociguat for the treatment of pulmonary hypertension
[作者:Schermuly, RT; Janssen, W; Weissmann, N; Stasch, JP; Grimminger, F; Ghofrani, HA,期刊:Expert opinion on investigational drugs, 页码:567-576 , 文章类型: Article,,卷期:2011年20-4]
- Areas covered: This review will help readers understand the mechanism of action of the soluble guanylate cyclase (sGC) stimulator riociguat (BAY 63-2521) and will provide a comprehensive summary regarding efficacy and sa...
- Naloxone as part of a prolonged release oxycodone/naloxone combination reduces oxycodone-induced slowing of gastrointestinal transit in healthy volunteers
[作者:Smith, K; Hopp, M; Mundin, G; Bond, S; Bailey, P; Woodward, J; Palaniappan, K; Church, A; Limb, M; Connor, A,期刊:Expert opinion on investigational drugs, 页码:427-439 , 文章类型: Article,,卷期:2011年20-4]
- Methods: Fifteen healthy male volunteers received: oxycodone 10 and 20 mg, oxycodone/naloxone 10/5 and 20/10 mg (all as prolonged release tablets) and placebo. Each dose was radiolabelled and administered with a capsule ...
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