- Combinatorial biosynthesis, metabolic engineering and mutasynthesis for the generation of new aminocoumarin antibiotics
[作者:Heide, L; Gust, B; Anderle, C; Li, SM,期刊:Current Topics in Medicinal Chemistry, 页码:667-679 , 文章类型: Review,,卷期:2008年8-8]
The aminocoumarin antibiotics novobiocin, clorobiocin and coumermycin A1 are produced by different Streptomyces strains. They are potent inhibitors of bacterial gyrase and topoisomerase IV, and novobiocin has been lic...
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