- Fukushima-derived radionuclides in the ocean and biota off Japan
[作者:Buesseler, KO; Jayne, SR; Fisher, NS; Rypina, II; Baumann, H; Baumann, Z; Breier, CF; Douglass, EM; George, J; Macdonald, AM; Miyamoto, H; Nishikawa, J; Pike, SM; Yoshida, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5984-5988 , 文章类型: Article,,卷期:2012年109-16]
- The T (o) over bar hoku earthquake and tsunami of March 11, 2011, resulted in unprecedented radioactivity releases from the Fukushima Dai-ichi nuclear power plants to the Northwest Pacific Ocean. Results are presented he...
- Patterns and plasticity in RNA-protein interactions enable recruitment of multiple proteins through a single site
[作者:Valley, CT; Porter, DF; Qiu, C; Campbell, ZT; Hall, TMT; Wickens, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6054-6059 , 文章类型: Article,,卷期:2012年109-16]
- mRNA control hinges on the specificity and affinity of proteins for their RNA binding sites. Regulatory proteins must bind their own sites and reject even closely related noncognate sites. In the PUF [Pumilio and fem-3 b...
- Shift-driven modulations of spin-echo signals
[作者:Smith, PES; Bensky, G; Alvarez, GA; Kurizki, G; Frydman, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5958-5961 , 文章类型: Article,,卷期:2012年109-16]
- Since the pioneering works of Carr-Purcell and Meiboom-Gill [Carr HY, Purcell EM (1954) Phys Rev 94:630; Meiboom S, Gill D (1985) Rev Sci Instrum 29:688], trains of p-pulses have featured amongst the main tools of quantu...
- Azidothymidine and other chain terminators are mutagenic for template-switch-generated genetic mutations
[作者:Seier, T; Zilberberg, G; Zeiger, DM; Lovett, ST,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6171-6174 , 文章类型: Article,,卷期:2012年109-16]
- The accumulation of mutations causes cell lethality and can lead to carcinogenesis. An important class of mutations, which are associated with mutational hotspots in many organisms, are those that arise by nascent strand...
- Peierls distortion mediated reversible phase transition in GeTe under pressure
[作者:Sun, ZM; Zhou, J; Mao, HK; Ahuja, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5948-5952 , 文章类型: Article,,卷期:2012年109-16]
- With the advent of big synchrotron facilities around the world, pressure is now routinely placed to design a new material or manipulate the properties of materials. In GeTe, an important phase-change material that utiliz...
- Phase transitions in biogenic amorphous calcium carbonate
[作者:Gong, YUT; Killian, CE; Olson, IC; Appathurai, NP; Amasino, AL; Martin, MC; Holt, LJ; Wilt, FH; Gilbert, PUPA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6088-6093 , 文章类型: Article,,卷期:2012年109-16]
- Crystalline biominerals do not resemble faceted crystals. Current explanations for this property involve formation via amorphous phases. Using X-ray absorption near-edge structure (XANES) spectroscopy and photoelectron e...
- Tissue-specific splicing of an Ndufs6 gene-trap insertion generates a mitochondrial complex I deficiency-specific cardiomyopathy
[作者:Ke, BX; Pepe, S; Grubb, DR; Komen, JC; Laskowski, A; Rodda, FA; Hardman, BM; Pitt, JJ; Ryan, MT; Lazarou, M; Koleff, J; Cheung, MMH; Smolich, JJ; Thorburn, DR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6165-6170 , 文章类型: Article,,卷期:2012年109-16]
- Mitochondrial complex I (CI) deficiency is the most common mitochondrial enzyme defect in humans. Treatment of mitochondrial disorders is currently inadequate, emphasizing the need for experimental models. In humans, mut...
- TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements
[作者:Tan, AY; Riley, TR; Coady, T; Bussemaker, HJ; Manley, JL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6030-6035 , 文章类型: Article,,卷期:2012年109-16]
- TLS/FUS (TLS) is a multifunctional protein implicated in a wide range of cellular processes, including transcription and mRNA processing, as well as in both cancer and neurological disease. However, little is currently k...
- Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage
[作者:Oja, T; Klika, KD; Appassamy, L; Sinkkonen, J; Mantsala, P; Niemi, J; Metsa-Ketela, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6024-6029 , 文章类型: Article,,卷期:2012年109-16]
- Carbohydrate moieties are important components of natural products, which are often imperative for the solubility and biological activity of the compounds. The aromatic polyketide alnumycin A contains an extraordinary su...
- Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
[作者:Yu, P; Steel, JC; Zhang, ML; Morris, JC; Waitz, R; Fasso, M; Allison, JP; Waldmann, TA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6187-6192 , 文章类型: Article,,卷期:2012年109-16]
- IL-15 has potential as an immunotherapeutic agent for cancer treatment because of its ability to effectively stimulate CD8 T cell, natural killer T cell, and natural killer cell immunity. However, its effectiveness may b...
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