- Involvement of leucine zipper transcription factor-like protein 1 (Lztfl1) in the attenuation of cognitive impairment by exercise training
[作者:Sakurai, T; Ogasawara, J; Kizaki, T; Ishibashi, Y; Fujiwara, T; Akagawa, K; Izawa, T; Oh-ishi, S; Haga, S; Ohno, H,期刊:Biochemical and Biophysical Research Communications, 页码:125-129 , 文章类型: Article,,卷期:2011年416-1-2]
- It is well known that exercise prevents and reduces cognitive impairment. In the present study, we focused on exercise training as a tool to prevent cognitive impairment, and searched for novel molecules that may relate ...
- Genetic ablation and chemical inhibition of IP3R1 reduce mutant huntingtin aggregation
[作者:Bauer, PO; Hudec, R; Ozaki, S; Okuno, M; Ebisui, E; Mikoshiba, K; Nukina, N,期刊:Biochemical and Biophysical Research Communications, 页码:13-17 , 文章类型: Article,,卷期:2011年416-1-2]
- Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by an expansion of the polyglutamine (polyQ) stretch in huntingtin (htt). Previously, it has been shown that inhibition of the inositol...
- Dynamic behavior of small heat shock protein inhibition on amyloid fibrillization of a small peptide (SSTSAA) from RNase A
[作者:Xi, D; Dong, X; Deng, W; Lai, LH,期刊:Biochemical and Biophysical Research Communications, 页码:130-134 , 文章类型: Article,,卷期:2011年416-1-2]
- Small heat shock proteins, a class of molecular chaperones, are reported to inhibit amyloid fibril formation in vitro, while the mechanism of inhibition remains unknown. In the present study, we investigated the mechanis...
- Regulation of miR-200c by nuclear receptors PPAR alpha, LRH-1 and SHP
[作者:Zhang, YX; Yang, ZH; Whitby, R; Wang, L,期刊:Biochemical and Biophysical Research Communications, 页码:135-139 , 文章类型: Article,,卷期:2011年416-1-2]
- We investigated regulation of miR-200c expression by nuclear receptors. Ectopic expression of miR-200c inhibited MHCC97H cell migration, which was abrogated by the synergistic effects of PPAR alpha and LRH-1 siRNAs. The ...
- Structure and dimerization of translation initiation factor aIF5B in solution
[作者:Rasmussen, LCV; Oliveira, CLP; Byron, O; Jensen, JM; Pedersen, JS; Sperling-Petersen, HU; Mortensen, KK,期刊:Biochemical and Biophysical Research Communications, 页码:140-145 , 文章类型: Article,,卷期:2011年416-1-2]
- Translation initiation factor 5B (IF5B) is required for initiation of protein synthesis. The solution structure of archaeal IF5B (aIF5B) was analysed by small-angle X-ray scattering (SAXS) and dynamic light scattering (D...
- Inhibition of PCGF2 enhances granulocytic differentiation of acute promyelocytic leukemia cell line HL-60 via induction of HOXA7
[作者:Jo, S; Lee, H; Kim, S; Hwang, EM; Park, JY; Kang, SS; Chung, H,期刊:Biochemical and Biophysical Research Communications, 页码:86-91 , 文章类型: Article,,卷期:2011年416-1-2]
- This study tested the hypothesis that Polycomb Repressive Complex 1 (PRC1) may play a negative role in the granulocytic differentiation of acute promyelocytic leukemia (APL) cells. We first examined the expression of PRC...
- Crystal structure and thermostability of a putative alpha-glucosidase from Thermotoga neapolitana
[作者:Yun, BY; Jun, SY; Kim, NA; Yoon, BY; Piao, S; Park, SH; Jeong, SH; Lee, H; Ha, NC,期刊:Biochemical and Biophysical Research Communications, 页码:92-98 , 文章类型: Article,,卷期:2011年416-1-2]
- Glycoside hydrolase family 4 (GH4) represents an unusual group of glucosidases with a requirement for NAD(+), Mn(2+), and reducing conditions. We found a putative alpha-glucosidase belonging to GH4 in hyperthermophilic G...
- Triptolide inhibits COX-2 expression by regulating mRNA stability in TNF-alpha-treated A549 cells
[作者:Sun, LX; Zhang, S; Jiang, ZZ; Huang, X; Wang, T; Huang, X; Li, H; Zhang, LY,期刊:Biochemical and Biophysical Research Communications, 页码:99-105 , 文章类型: Article,,卷期:2011年416-1-2]
- Cyclooxygenase-2 (COX-2) over-expression is frequently associated with human non-small-cell lung cancer (NSCLC) and involved in tumor proliferation, invasion, angiogenesis and resistance to apoptosis. In the present stud...
- Involvement of the mitochondrial compartment in human NCL fibroblasts
[作者:Pezzini, F; Gismondi, F; Tessa, A; Tonin, P; Carrozzo, R; Mole, SE; Santorelli, FM; Simonati, A,期刊:Biochemical and Biophysical Research Communications, 页码:159-164 , 文章类型: Article,,卷期:2011年416-1-2]
- Neuronal ceroid lipofuscinosis (NCL) are a group of progressive neurodegenerative disorders of childhood, characterized by the endo-lysosomal storage of autofluorescent material. Impaired mitochondrial function is often ...
- Newly identified essential amino acid residues affecting Delta(8)-sphingolipid desaturase activity revealed by site-directed mutagenesis
[作者:Li, SF; Song, LY; Zhang, GJ; Yin, WB; Chen, YH; Wang, RRC; Hu, ZM,期刊:Biochemical and Biophysical Research Communications, 页码:165-171 , 文章类型: Article,,卷期:2011年416-1-2]
- In order to identify amino acid residues crucial for the enzymatic activity of Delta(8)-sphingolipid desaturases, a sequence comparison was performed among Delta(8)-sphingolipid desaturases and Delta(6)-fatty acid desatu...
- 5 '-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells
[作者:Wu, L; Huang, XJ; Yang, CH; Deng, SS; Qian, M; Zang, Y; Li, J,期刊:Biochemical and Biophysical Research Communications, 页码:172-177 , 文章类型: Article,,卷期:2011年416-1-2]
- The steroid hormone progesterone is an essential regulator of the cellular processes that are required for the development and maintenance of reproductive function. The diverse effects of progesterone are mediated by the...
- Gold nanoparticle-assisted delivery of small, highly structured RNA into the nuclei of human cells
[作者:Ryou, SM; Kim, JM; Yeom, JH; Hyun, S; Kim, S; Han, MS; Kim, SW; Bae, J; Rhee, S; Lee, K,期刊:Biochemical and Biophysical Research Communications, 页码:178-183 , 文章类型: Article,,卷期:2011年416-1-2]
- Previous studies have shown that functionalized gold nanoparticles (AuNPs) can be used as a general platform for loading and delivering DNA oligonucleotides and short hairpin RNA to living systems. Here, we report the ab...
- Suppression of Nrdp1 toxicity by Parkin in Drosophila models
[作者:Tan, Y; Yu, FR; Pereira, A; Morin, P; Zhou, JH,期刊:Biochemical and Biophysical Research Communications, 页码:18-23 , 文章类型: Article,,卷期:2011年416-1-2]
- Nrdp1 is a RING finger ubiquitin E3 ligase that interacts with Parkin, and promotes the degradation of Parkin, a causative protein for early onset Autosomal Recessive Juvenile Parkinsonism (AR-JP). To investigate if Nrdp...
- Expression of the prion-like protein Shadoo in the developing mouse embryo
[作者:Young, R; Bouet, S; Polyte, J; Le Guillou, S; Passet, B; Vilotte, M; Castille, J; Beringue, V; Le Provost, F; Laude, H; Vilotte, JL,期刊:Biochemical and Biophysical Research Communications, 页码:184-187 , 文章类型: Article,,卷期:2011年416-1-2]
- The prion-like protein Shadoo has been suggested to compensate for the lack of PrP in Prnp-knockout mice, explaining their lack of extreme phenotype. In adult mice, both PrP and Shadoo have shown overlapping expression p...
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