- TRPA1 and Substance P Mediate Colitis in Mice
[作者：Engel, MA; Leffler, A; Niedermirtl, F; Babes, A; Zimmermann, K; Filipovic, MR; Izydorczyk, I; Eberhardt, M; Kichko, TI; Mueller-Tribbensee, SM; Khalil, M; Siklosi, N; Nau, C; Ivanovic-Burmazovic, I; Neuhuber, WL; Becker, C; Neurath, MF; Reeh, PW,期刊：Gastroenterology, 页码：1346-1358 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: The neuropeptides calcitonin gene-related peptide (CGRP) and substance P, and calcium channels, which control their release from extrinsic sensory neurons, have important roles in experimental colitis....
- BCL9-2 Promotes Early Stages of Intestinal Tumor Progression
[作者：Brembeck, FH; Wiese, M; Zatula, N; Grigoryan, T; Dai, YY; Fritzmann, J; Birchmeier, W,期刊：Gastroenterology, 页码：1359-U810 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: The roles of the 2 BCL9 and 2 Pygopus genes in Wnt to beta-catenin signaling are not clear in vertebrates. We examined their expression and function in normal and tumor intestinal epithelia in mice and...
- Disruption of the Mouse Protein Tyrosine Kinase 6 Gene Prevents STAT3 Activation and Confers Resistance to Azoxymethane
[作者：Gierut, J; Zheng, Y; Bie, WJ; Carroll, RE; Ball-Kell, S; Haegebarth, A; Tyner, AL,期刊：Gastroenterology, 页码：1371-U822 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: Protein tyrosine kinase 6 (PTK6) is expressed throughout the gastrointestinal tract and is a negative regulator of proliferation that promotes differentiation and DNA-damage-induced apoptosis in the sm...
- Transforming Growth Factor-beta in the Gastrointestinal and Hepatic Tumor Microenvironment
[作者：Achyut, BR; Yang, L,期刊：Gastroenterology, 页码：1167-1178 , 文章类型： Review，,卷期：2011年141-4]
- Transforming growth factor (TGF)-beta is a multifunctional cytokine that has important roles in tumor formation, progression, and metastasis. TGF-beta is overproduced, and its signaling is deregulated, in a variety of hu...
- Risk Factors for Progression of Low-Grade Dysplasia in Patients With Barrett's Esophagus
[作者：Wani, S; Falk, GW; Post, J; Yerian, L; Hall, M; Wang, A; Gupta, N; Gaddam, S; Singh, M; Singh, V; Chuang, KY; Boolchand, V; Gavini, H; Kuczynski, J; Sud, P; Bansal, A; Rastogi, A; Mathur, SC; Young, P; Cash, B; Goldblum, J; Lieberman, DA; Sampliner, RE; Sharma, P,期刊：Gastroenterology, 页码：1179-U590 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: Data vary on the progression of low-grade dysplasia (LGD) in patients with Barrett's esophagus (BE); in patients with LGD, we investigated the incidence of high-grade dysplasia (HGD) and esophageal ade...
- The Prevalence of Celiac Disease Among Patients With Nonconstipated Irritable Bowel Syndrome Is Similar to Controls
[作者：Cash, BD; Rubenstein, JH; Young, PE; Gentry, A; Nojkov, B; Lee, D; Andrews, AH; Dobhan, R; Chey, WD,期刊：Gastroenterology, 页码：1187-1193 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: Guidelines recommend that patients with symptoms of nonconstipated irritable bowel syndrome (NC-IBS) undergo testing for celiac disease (CD). We evaluated the prevalence of CD antibodies, and biopsy co...
- Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis
[作者：Colombel, JF; Rutgeerts, P; Reinisch, W; Esser, D; Wang, YX; Lang, YH; Marano, CW; Strauss, R; Oddens, BJ; Feagan, BG; Hanauer, SB; Lichtenstein, GR; Present, D; Sands, BE; Sandborn, WJ,期刊：Gastroenterology, 页码：1194-1201 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: In the Active Ulcerative Colitis Trial (ACT)-1 and ACT-2, patients with ulcerative colitis treated with infliximab were more likely than those given placebo to have a clinical response, undergo remissi...
- Improvement in Liver Pathology of Patients With beta-Thalassemia Treated With Deferasirox for at Least 3 Years
[作者：Deugnier, Y; Turlin, B; Ropert, M; Cappellini, MD; Porter, JB; Giannone, V; Zhang, YY; Griffel, L; Brissot, P,期刊：Gastroenterology, 页码：1202-U618 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: Most data on the effects of iron chelation therapy for patients with liver fibrosis come from small studies. We studied the effects of the oral iron chelator deferasirox on liver fibrosis and necroinfl...
- Notch1 Regulates the Effects of Matrix Metalloproteinase-9 on Colitis-Associated Cancer in Mice
[作者：Garg, P; Jeppsson, S; Dalmasso, G; Ghaleb, AM; McConnell, BB; Yang, VW; Gewirtz, AT; Merlin, D; Sitaraman, SV,期刊：Gastroenterology, 页码：1381-1392 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: Inflammatory bowel disease increases the risks of colon cancer and colitis-associated cancer (CAC). Epithelial cell-derived matrix metalloproteinase (MMP)-9 mediates inflammation during acute colitis a...
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