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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Inflammatory Bowel Disease: An Update on the Fundamental Biology and Clinical Management INTRODUCTION [作者：Blumberg, R; Cho, J; Lewis, J; Wu, G,期刊：Gastroenterology, 页码：1701-1703 , 文章类型： Editorial Material，,卷期：2011年140-6] Recent Insights Into the Genetics of Inflammatory Bowel Disease [作者：Cho, JH; Brant, SR,期刊：Gastroenterology, 页码：1704-U21 , 文章类型： Article，,卷期：2011年140-6] Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders that comprise Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies have identified approximately 100 loci that are sig... Development of the Human Gastrointestinal Microbiota and Insights From High-Throughput Sequencing [作者：Dominguez-Bello, MG; Blaser, MJ; Ley, RE; Knight, R,期刊：Gastroenterology, 页码：1713-1719 , 文章类型： Article，,卷期：2011年140-6] Little was known about the development of the gastrointestinal (GI) tract microbiota, until recently, because of difficulties in obtaining sufficient sequence information from enough people or time points. Now, with decr... The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases [作者：Chassaing, B; Darfeuille-Michaud, A,期刊：Gastroenterology, 页码：1720-U40 , 文章类型： Article，,卷期：2011年140-6] Intestinal inflammation arises from abnormal host-microbe interactions. The perturbations of homeostatic coexistence involve host genetic factors, barrier function, innate and adaptive immunity, as well as qualitative an... Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease [作者：Abraham, C; Medzhitov, R,期刊：Gastroenterology, 页码：1729-1737 , 文章类型： Article，,卷期：2011年140-6] The intestinal immune system defends against pathogens and entry of excessive intestinal microbes; simultaneously, a state of immune tolerance to resident intestinal microbes must be maintained. Perturbation of this bala... Autophagy, Microbial Sensing, Endoplasmic Reticulum Stress, and Epithelial Function in Inflammatory Bowel Disease [作者：Kaser, A; Blumberg, RS,期刊：Gastroenterology, 页码：1738-U61 , 文章类型： Article，,卷期：2011年140-6] Increasing evidence has emerged that supports an important intersection between 3 fundamental cell biologic pathways in the pathogenesis of inflammatory bowel disease. These include the intersection between autophagy, as... Hypoxia and Metabolic Factors That Influence Inflammatory Bowel Disease Pathogenesis [作者：Glover, LE; Colgan, SP,期刊：Gastroenterology, 页码：1748-1755 , 文章类型： Article，,卷期：2011年140-6] The gastrointestinal epithelium is anatomically positioned to provide a selective barrier between the anaerobic lumen and lamina propria, which has a high rate of metabolism. Supported by a complex vasculature, this impo... Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases [作者：Strober, W; Fuss, IJ,期刊：Gastroenterology, 页码：1756-U82 , 文章类型： Article，,卷期：2011年140-6] The cytokine responses characterizing the inflammatory bowel diseases are the key pathophysiologic elements that govern the initiation, evolution, and, ultimately, the resolution of these forms of inflammation. Studies d... Regulation of Homeostasis and Inflammation in the Intestine [作者：MacDonald, TT; Monteleone, I; Fantini, MC; Monteleone, G,期刊：Gastroenterology, 页码：1768-1775 , 文章类型： Article，,卷期：2011年140-6] The gastrointestinal tract is the largest immune interface with the environment. Exposure to large numbers of dietary and microbial antigens requires complex and highly regulated immune responses by different mucosal cel... Blocking Lymphocyte Localization to the Gastrointestinal Mucosa as a Therapeutic Strategy for Inflammatory Bowel Diseases [作者：Villablanca, EJ; Cassani, B; von Andrian, UH; Mora, JR,期刊：Gastroenterology, 页码：1776-U104 , 文章类型： Article，,卷期：2011年140-6] Lymphocyte migration (homing) to specific tissues has an important role during protective and pathological immune responses, including inflammatory bowel diseases. Lymphocytes use integrin alpha 4 beta 7 and the chemokin... Epidemiology and Natural History of Inflammatory Bowel Diseases [作者：Cosnes, J; Gower-Rousseau, C; Seksik, P; Cortot, A,期刊：Gastroenterology, 页码：1785-U118 , 文章类型： Article，,卷期：2011年140-6] In the West, the incidence and prevalence of inflammatory bowel diseases has increased in the past 50 years, up to 8-14/100,000 and 120-200/100,000 persons, respectively, for ulcerative colitis (UC) and 6-15/100,000 and ... New Concepts in Intestinal Imaging for Inflammatory Bowel Diseases [作者：Fletcher, JG; Fidler, JL; Bruining, DH; Huprich, JE,期刊：Gastroenterology, 页码：1795-U137 , 文章类型： Article，,卷期：2011年140-6] In the last decade, multiple imaging technologies have been developed that improve visualization of the mucosal, mural, and perienteric inflammation associated with inflammatory bowel diseases. Whereas these technologies... Intestinal Inflammation and Cancer [作者：Ullman, TA; Itzkowitz, SH,期刊：Gastroenterology, 页码：1807-U148 , 文章类型： Article，,卷期：2011年140-6] Patients with ulcerative colitis and Crohn's disease are at increased risk for developing colorectal cancer (CRC). Chronic inflammation is believed to promote carcinogenesis. The risk for colon cancer increases with the ... The Utility of Biomarkers in the Diagnosis and Therapy of Inflammatory Bowel Disease [作者：Lewis, JD,期刊：Gastroenterology, 页码：1817-U160 , 文章类型： Article，,卷期：2011年140-6] Fecal and serologic biomarkers can be used in the diagnosis and management of inflammatory bowel disease (IBD). Fecal markers such as calprotectin and lactoferrin have been studied for their ability to identify patients ... Conventional Medical Management of Inflammatory Bowel Disease [作者：Burger, D; Travis, S,期刊：Gastroenterology, 页码：1827-U173 , 文章类型： Article，,卷期：2011年140-6] Conventional therapies for ulcerative colitis and Crohn's disease (CD) include aminosalicylates, corticosteroids, thiopurines, methotrexate, and antitumor necrosis factor agents. A time-structured approach is required fo... Future Therapeutic Approaches for Inflammatory Bowel Diseases [作者：Plevy, SE; Targan, SR,期刊：Gastroenterology, 页码：1838-1846 , 文章类型： Article，,卷期：2011年140-6] In this review, we speculate about future therapeutic approaches for inflammatory bowel diseases (IBDs), focusing on the need for better preclinical and clinical models and approaches beyond small molecules and systemica...