- A Functional Single Nucleotide Polymorphism in Mucin 1, at Chromosome 1q22, Determines Susceptibility to Diffuse-Type Gastric Cancer
[作者：Saeki, N; Saito, A; Choi, IJ; Matsuo, K; Ohnami, S; Totsuka, H; Chiku, S; Kuchiba, A; Lee, YS; Yoon, KA; Kook, MC; Park, SR; Kim, YW; Tanaka, H; Tajima, K; Hirose, H; Tanioka, F; Matsuno, Y; Sugimura, H; Kato, S; Nakamura, T; Nishina, T; Yasui, W; Aoyagi, K; Sasaki, H; Yanagihara, K; Katai, H; Shimoda, T; Yoshida, T; Nakamura, Y; Hirohashi, S; Sakamoto, H,期刊：Gastroenterology, 页码：892-902 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: Two major types of gastric cancer, intestinal and diffuse, develop through distinct mechanisms; the diffuse type is considered to be more influenced by genetic factors, although the mechanism is unknow...
- The G-Protein-Coupled Receptor GPR40 Directly Mediates Long-Chain Fatty Acid-Induced Secretion of Cholecystokinin
[作者：Liou, AP; Lu, XP; Sei, Y; Zhao, XL; Pechhold, S; Carrero, RJ; Raybould, HE; Wank, S,期刊：Gastroenterology, 页码：903-U318 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: Long-chain fatty acid receptors G-protein-coupled receptor 40 (GPR40) (FFAR1) and GPR120 have been implicated in the chemosensation of dietary fats. I cells in the intestine secrete cholecystokinin (CC...
- Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small Intestine
[作者：Tamura, A; Hayashi, H; Imasato, M; Yamazaki, Y; Hagiwara, A; Wada, M; Noda, T; Watanabe, M; Suzuki, Y; Tsukita, S,期刊：Gastroenterology, 页码：913-923 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: In the small intestine, the paracellular transport of Na+ is thought to be critical for luminal Na+-homeostasis and the transcellular absorption of nutrients by Na+-driven transporters. Na+ is supplied...
- MAGI-3 Competes With NHERF-2 to Negatively Regulate LPA2 Receptor Signaling in Colon Cancer Cells
[作者：Lee, SJ; Ritter, SL; Zhang, HC; Shim, H; Hall, RA; Yun, CC,期刊：Gastroenterology, 页码：924-934 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: Lysophosphatidic acid (LPA) is a potent inducer of colon cancer and LPA receptor type 2 (LPA(2)) is overexpressed in colon tumors. LPA(2) interacts with membrane-associated guanylate kinase with invert...
- An Immunoconjugate of Anti-CD24 and Pseudomonas Exotoxin Selectively Kills Human Colorectal Tumors in Mice
[作者：Shapira, S; Shapira, A; Starr, A; Kazanov, D; Kraus, S; Benhar, I; Arber, N,期刊：Gastroenterology, 页码：935-946 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: Effective and selective treatment options are needed for patients with colorectal cancer (CRC). The CD24 mucin-like glycoprotein is over-expressed in CRCs; monoclonal antibodies (mAbs) against CD24 inh...
- IgA-Producing Plasma Cells Originate From Germinal Centers That Are Induced by B-Cell Receptor Engagement in Humans
[作者：Barone, F; Vossenkamper, A; Boursier, L; Su, W; Watson, A; John, S; Dunn-Walters, DK; Fields, P; Wijetilleka, S; Edgeworth, JD; Spencer, J,期刊：Gastroenterology, 页码：947-956 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: IgA contributes to homeostatic balance between host and intestinal microbiota. Mechanisms that initiate the IgA response are unclear and likely to differ between humans and animal models. We used multi...
- Bone Marrow Stromal Cell Transplants Prevent Experimental Enterocolitis and Require Host CD11b(+) Splenocytes
[作者：Parekkadan, B; Upadhyay, R; Dunham, J; Iwamoto, Y; Mizoguchi, E; Mizoguchi, A; Weissleder, R; Yarmush, ML,期刊：Gastroenterology, 页码：966-U385 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: Bone marrow stromal cells (MSCs) are being evaluated as a cellular therapeutic for immune-mediated diseases. We investigated the effects of MSCs in mice with chemically induced colitis and determined t...
- Association Between Composition of the Human Gastrointestinal Microbiome and Development of Fatty Liver With Choline Deficiency
[作者：Spencer, MD; Hamp, TJ; Reid, RW; Fischer, LM; Zeisel, SH; Fodor, AA,期刊：Gastroenterology, 页码：976-986 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: Nonalcoholic fatty liver disease affects up to 30% of the US population, but the mechanisms underlying this condition are incompletely understood. We investigated how diet standardization and choline d...
- BASIC-LIVER, PANCREAS, AND BILIARY TRACT
[作者：Lugea, A; Tischler, D; Nguyen, J; Gong, J; Gukovsky, I; French, SW; Gorelick, FS; Pandol, SJ,期刊：Gastroenterology, 页码：987-U415 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: Endoplasmic reticulum (ER) stress responses (collectively known the unfolded protein response [UPR]) have important roles in several human disorders, but their contribution to alcoholic pancreatitis is...
- Human Bone Marrow-Derived Clonal Mesenchymal Stem Cells Inhibit Inflammation and Reduce Acute Pancreatitis in Rats
[作者：Jung, KH; Song, SU; Yi, T; Jeon, MS; Hong, SW; Zheng, HM; Lee, HS; Choi, MJ; Lee, DH; Hong, SS,期刊：Gastroenterology, 页码：998-U430 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: Acute pancreatitis (AP) has a high mortality rate; repetitive AP induces chronic AP and pancreatic adenocarcinoma. Mesenchymal stem cells (MSCs) have immunoregulatory effects and reduce inflammation. W...
- Activin A, p15INK4b Signaling, and Cell Competition Promote Stem/Progenitor Cell Repopulation of Livers in Aging Rats
[作者：Menthena, A; Koehler, CI; Sandhu, JS; Yovchev, MI; Hurston, E; Shafritz, DA; Oertel, M,期刊：Gastroenterology, 页码：1009-U450 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: Highly proliferative fetal liver stem/progenitor cells (FLSPCs) repopulate livers of normal recipients by cell competition. We investigated the mechanisms by which FLSPCs repopulate livers of older com...
- Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C
[作者：Dill, MT; Duong, FHT; Vogt, JE; Bibert, S; Bochud, PY; Terracciano, L; Papassotiropoulos, A; Roth, V; Heim, MH,期刊：Gastroenterology, 页码：1021-U471 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: The host immune response during the chronic phase of hepatitis C virus infection varies among individuals; some patients have a no interferon (IFN) response in the liver, whereas others have full activ...
- Recombinant HCV Variants With NS5A From Genotypes 1-7 Have Different Sensitivities to an NS5A Inhibitor but Not Interferon-alpha
[作者：Scheel, TKH; Gottwein, JM; Mikkelsen, LS; Jensen, TB; Bukh, J,期刊：Gastroenterology, 页码：1032-U488 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: Heterogeneity in the hepatitis C virus (HCV) protein NS5A influences its sensitivity to interferon-based therapy. Furthermore, NS5A is an important target for development of HCV-specific inhibitors. We...
- Biliary Sterol Secretion Is Required for Functional In Vivo Reverse Cholesterol Transport in Mice
[作者：Nijstad, N; Gautier, T; Briand, F; Rader, DJ; Tietge, UJF,期刊：Gastroenterology, 页码：1043-1051 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: High-density lipoproteins (HDLs) protect against atherosclerotic cardiovascular disease, mainly by promoting reverse cholesterol transport (RCT). Biliary sterol secretion supposedly represents the fina...
- Liver X Receptor Signaling Is a Determinant of Stellate Cell Activation and Susceptibility to Fibrotic Liver Disease
[作者：Beaven, SW; Wroblewski, K; Wang, JH; Hong, C; Bensinger, S; Tsukamoto, H; Tontonoz, P,期刊：Gastroenterology, 页码：1052-1062 , 文章类型： Article，,卷期：2011年140-3]
- BACKGROUND & AIMS: Liver X receptors (LXRs) are lipid-activated nuclear receptors with important roles in cholesterol transport, lipogenesis, and anti-inflammatory signaling. Hepatic stellate cells activate during chroni...
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