- Lansoprazole, a Proton Pump Inhibitor, Mediates Anti-Inflammatory Effect in Gastric Mucosal Cells through the Induction of Heme Oxygenase-1 via Activation of NF-E2-Related Factor 2 and Oxidation of Kelch-Like ECH-Associating Protein 1
[作者:Takagi, T; Naito, Y; Okada, H; Ishii, T; Mizushima, K; Akagiri, S; Adachi, S; Handa, O; Kokura, S; Ichikawa, H; Itoh, K; Yamamoto, M; Matsui, H; Yoshikawa, T,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:255-264 , 文章类型: Article,,卷期:2009年331-1]
- Induction of heme oxygenase-1 (HO-1) expression has been associated with cytoprotective and anti-inflammatory actions of lansoprazole, a proton pump inhibitor, but the underlying molecular mechanisms remain largely unres...
- Determination of Adenosine A(1) Receptor Agonist and Antagonist Pharmacology Using Saccharomyces cerevisiae: Implications for Ligand Screening and Functional Selectivity
[作者:Stewart, GD; Valant, C; Dowell, SJ; Mijaljica, D; Devenish, RJ; Scammells, PJ; Sexton, PM; Christopoulos, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:277-286 , 文章类型: Article,,卷期:2009年331-1]
- The budding yeast, Saccharomyces cerevisiae, is a convenient system for coupling heterologous G protein-coupled receptors (GPCRs) to the pheromone response pathway to facilitate empirical ligand screening and/or GPCR mut...
- Molecular Basis for the Selectivity of the Mammalian Bombesin Peptide, Neuromedin B, for Its Receptor
[作者:Gonzalez, N; Nakagawa, T; Mantey, SA; Sancho, V; Uehara, H; Katsuno, T; Jensen, RT,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:265-276 , 文章类型: Article,,卷期:2009年331-1]
- The mammalian bombesin (Bn) peptides, neuromedin B (NMB) and gastrin-releasing peptide (GRP), have widespread actions in many tissues, and their effects are mediated by two closely related G-protein-coupled receptors, th...
- Functional Selectivity of Natural and Synthetic Prostaglandin EP4 Receptor Ligands
[作者:Leduc, M; Breton, B; Gales, C; Le Gouill, C; Bouvier, M; Chemtob, S; Heveker, N,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:297-307 , 文章类型: Article,,卷期:2009年331-1]
- Classically, the prostaglandin E-2 (PGE(2)) receptor EP4 has been classified as coupling to the G alpha(s) subunit, leading to intracellular cAMP increases. However, EP4 signaling has been revealed to be more complex and...
- The Role of Nucleoside Transporters in the Erythrocyte Disposition and Oral Absorption of Ribavirin in the Wild-Type and Equilibrative Nucleoside Transporter 1(-/-) Mice
[作者:Endres, CJ; Moss, AM; Govindarajan, R; Choi, DS; Unadkat, JD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:287-296 , 文章类型: Article,,卷期:2009年331-1]
- Ribavirin [1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide] is the treatment of choice for hepatitis C virus infection. Ribavirin is a substrate of several nucleoside transporters, including the equilibrative nu...
- Rescue of Functional F508del Cystic Fibrosis Transmembrane Conductance Regulator by Vasoactive Intestinal Peptide in the Human Nasal Epithelial Cell Line JME/CF15
[作者:Rafferty, S; Alcolado, N; Norez, C; Chappe, F; Pelzer, S; Becq, F; Chappe, V,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:2-13 , 文章类型: Article,,卷期:2009年331-1]
- F508del is the most common cystic fibrosis-causing mutation that induces early degradation and poor trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels to the apical membrane of ep...
- Silibinin Attenuates Amyloid beta(25-35) Peptide-Induced Memory Impairments: Implication of Inducible Nitric-Oxide Synthase and Tumor Necrosis Factor-alpha in Mice
[作者:Lu, P; Mamiya, T; Lu, LL; Mouri, A; Niwa, M; Hiramatsu, M; Zou, LB; Nagai, T; Ikejima, T; Nabeshima, T,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:319-326 , 文章类型: Article,,卷期:2009年331-1]
- In Alzheimer's disease (AD), the deposition of amyloid peptides is invariably associated with oxidative stress and inflammatory responses. Silibinin (silybin), a flavonoid derived from the herb milk thistle, has potent a...
- Novel Environment and GABA Agonists Alter Event-Related Potentials in N-Methyl-D-aspartate NR1 Hypomorphic and Wild-Type Mice
[作者:Bodarky, CL; Halene, TB; Ehrlichman, RS; Banerjee, A; Ray, R; Hahn, CG; Jonak, G; Siegel, SJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:308-318 , 文章类型: Article,,卷期:2009年331-1]
- Clinical and experimental data suggest dysregulation of N-methyl-D-aspartate receptor (NMDAR)-mediated glutamatergic pathways in schizophrenia. The interaction between NMDAR-mediated abnormalities and the response to nov...
- Matrix Metalloprotease-9 Inhibition Improves Amyloid beta-Mediated Cognitive Impairment and Neurotoxicity in Mice
[作者:Mizoguchi, H; Takuma, K; Fukuzaki, E; Ibi, D; Someya, E; Akazawa, KH; Alkam, T; Tsunekawa, H; Mouri, A; Noda, Y; Nabeshima, T; Yamada, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:14-22 , 文章类型: Article,,卷期:2009年331-1]
- In Alzheimer's disease (AD), the expression of matrix metalloproteases (MMPs), which are capable of degrading extracellular matrix proteins, is increased in the brain. Previous studies with cultured glial cells have demo...
- Chronic Ethanol Consumption Lessens the Gain of Body Weight, Liver Triglycerides, and Diabetes in Obese ob/ob Mice
[作者:Fromenty, B; Vadrot, N; Massart, J; Turlin, B; Barri-Ova, N; Letteron, P; Fautrel, A; Robin, MA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:23-34 , 文章类型: Article,,卷期:2009年331-1]
- Clinical studies suggest that moderate alcohol consumption can have beneficial effects, in particular regarding cardiovascular events, insulin resistance, and type 2 diabetes. In this study, lean and obese diabetic ob/ob...
- Abrogation of Mitogen-Activated Protein Kinase and Akt Signaling by Vandetanib Synergistically Potentiates Histone Deacetylase Inhibitor-Induced Apoptosis in Human Glioma Cells
[作者:Jane, EP; Premkumar, DR; Addo-Yobo, SO; Pollack, IF,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:327-337 , 文章类型: Article,,卷期:2009年331-1]
- Vandetanib is a multitargeted tyrosine kinase inhibitor. Our initial studies demonstrated that this agent blocks vascular endothelial growth factor receptor, epidermal growth factor receptor, and platelet-derived growth ...
- Structure-Activity Relationship Studies of Fostriecin, Cytostatin, and Key Analogs, with PP1, PP2A, PP5, and (beta 12-beta 13)-Chimeras (PP1/PP2A and PP5/PP2A), Provide Further Insight into the Inhibitory Actions of Fostriecin Family Inhibitors
[作者:Swingle, MR; Amable, L; Lawhorn, BG; Buck, SB; Burke, CP; Ratti, P; Fischer, KL; Boger, DL; Honkanen, RE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:45-53 , 文章类型: Article,,卷期:2009年331-1]
- Fostriecin and cytostatin are structurally related natural inhibitors of serine/threonine phosphatases, with promising antitumor activity. The total synthesis of these antitumor agents has enabled the production of struc...
- Modulation of alpha(2)-Adrenoceptor Functions by Heterotrimeric G alpha(i) Protein Isoforms
[作者:Albarran-Juarez, J; Gilsbach, R; Piekorz, RP; Pexa, K; Beetz, N; Schneider, J; Nurnberg, B; Hein, L,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:35-44 , 文章类型: Article,,卷期:2009年331-1]
- Subtype diversity of heterotrimeric G proteins and G protein-coupled receptors enables a wide spectrum of signal transduction. However, the significance of isoforms within receptor or G protein subfamilies has not been f...
- Synthetic Analogs of FTY720 [2-Amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] Differentially Regulate Pulmonary Vascular Permeability in Vivo and in Vitro
[作者:Camp, SM; Bittman, R; Chiang, ET; Moreno-Vinasco, L; Mirzapoiazova, T; Sammani, S; Lu, X; Sun, C; Harbeck, M; Roe, M; Natarajan, V; Garcia, JGN; Dudek, SM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:54-64 , 文章类型: Article,,卷期:2009年331-1]
- Novel therapies are needed to address the vascular endothelial cell (EC) barrier disruption that occurs in inflammatory diseases such as acute lung injury (ALI). We previously demonstrated the potent barrier-enhancing ef...
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