- A Series of D-Amino Acid Oxidase Inhibitors Specifically Prevents and Reverses Formalin-Induced Tonic Pain in Rats
[作者:Gong, NA; Gao, ZY; Wang, YC; Li, XY; Huang, JL; Hashimoto, K; Wang, YX,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:282-293 , 文章类型: Article,,卷期:2011年336-1]
- We have found that mutation of D-amino acid oxidase (DAO) diminished formalin-induced tonic pain. The present research further studied the analgesic effects of a series of DAO inhibitors in this model. 5-Chlorobenzo[d]is...
- FYX-051: A Novel and Potent Hybrid-Type Inhibitor of Xanthine Oxidoreductase
[作者:Matsumoto, K; Okamoto, K; Ashizawa, N; Nishino, T,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:95-103 , 文章类型: Article,,卷期:2011年336-1]
- 4-[5-(Pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile (FYX-051) is a potent inhibitor of bovine milk xanthine oxidoreductase (XOR). Steady-state kinetics study showed that it initially behaved as a competitiv...
- Bis-Halogen-Anthraniloyl-Substituted Nucleoside 5 '-Triphosphates as Potent and Selective Inhibitors of Bordetella pertussis Adenylyl Cyclase Toxin
[作者:Geduhn, J; Dove, S; Shen, YQ; Tang, WJ; Konig, B; Seifert, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:104-115 , 文章类型: Article,,卷期:2011年336-1]
- Whooping cough is caused by Bordetella pertussis and still constitutes one of the top five causes of death in young children, particularly in developing countries. The calmodulin-activated adenylyl cyclase (AC) toxin Cya...
- Perivascular Delivery of Blebbistatin Reduces Neointimal Hyperplasia after Carotid Injury in the Mouse
[作者:Huang, JH; Zhang, JX; Pathak, A; Li, JX; Stouffer, GA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:116-126 , 文章类型: Article,,卷期:2011年336-1]
- Proliferation and migration of smooth muscle cells (SMC) require myosin II activity; thus, we examined whether blebbistatin, a cell-permeable selective inhibitor of myosin II ATP activity, would impair neointimal hyperpl...
- Inhaled Anesthetic Responses of Recombinant Receptors and Knockin Mice Harboring alpha 2(S270H/L277A) GABA(A) Receptor Subunits That Are Resistant to Isoflurane
[作者:Werner, DF; Swihart, A; Rau, V; Jia, F; Borghese, CM; McCracken, ML; Iyer, S; Fanselow, MS; Oh, I; Sonner, JM; Eger, EI; Harrison, NL; Harris, RA; Homanics, GE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:134-144 , 文章类型: Article,,卷期:2011年336-1]
- The mechanism by which the inhaled anesthetic isoflurane produces amnesia and immobility is not understood. Isoflurane modulates GABA(A) receptors (GABA(A)-Rs) in a manner that makes them plausible targets. We asked whet...
- Loss of Ethanol Conditioned Taste Aversion and Motor Stimulation in Knockin Mice with Ethanol-Insensitive alpha 2-Containing GABA(A) Receptors
[作者:Blednov, YA; Borghese, CM; McCracken, ML; Benavidez, JM; Geil, CR; Osterndorff-Kahanek, E; Werner, DF; Iyer, S; Swihart, A; Harrison, NL; Homanics, GE; Harris, RA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:145-154 , 文章类型: Article,,卷期:2011年336-1]
- GABA type A receptors (GABA(A)-Rs) are potential targets of ethanol. However, there are multiple subtypes of this receptor, and, thus far, individual subunits have not been definitively linked with specific ethanol behav...
- N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide(THIIC), a Novel Metabotropic Glutamate 2 Potentiator with Potential Anxiolytic/Antidepressant Properties: In Vivo Profiling Suggests a Link between Behavioral and Central Nervous System Neurochemical Changes
[作者:Fell, MJ; Witkin, JM; Falcone, JF; Katner, JS; Perry, KW; Hart, J; Rorick-Kehn, L; Overshiner, CD; Rasmussen, K; Chaney, SF; Benvenga, MJ; Li, X; Marlow, DL; Thompson, LK; Luecke, SK; Wafford, KA; Seidel, WF; Edgar, DM; Quets, AT; Felder, CC; Wang, XS; Heinz, BA; Nikolayev, A; Kuo, MS; Mayhugh, D; Khilevich, A; Zhang, DY; Ebert, PJ; Eckstein, JA; Ackermann, BL; Swanson, SP; Catlow, JT; Dean, RA; Jackson, K; Tauscher-Wisniewski, S; Marek, GJ; Schkeryantz, JM; Svensson, KA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:165-177 , 文章类型: Article,,卷期:2011年336-1]
- The normalization of excessive glutamatergic neurotransmission through the activation of metabotropic glutamate 2 (mGlu2) receptors may have therapeutic potential in a variety of psychiatric disorders, including anxiety/...
- Enterobacteria Modulate Intestinal Bile Acid Transport and Homeostasis through Apical Sodium-Dependent Bile Acid Transporter (SLC10A2) Expression
[作者:Miyata, M; Yamakawa, H; Hamatsu, M; Kuribayashi, H; Takamatsu, Y; Yamazoe, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:188-196 , 文章类型: Article,,卷期:2011年336-1]
- In our study, ampicillin (AMP)-mediated decrease of enterobacteria caused increases in hepatic bile acid concentration through (at least in part) elevation of bile acid synthesis in C57BL/6N mice. We investigated the inv...
- Intracellular GSH Depletion Triggered Mitochondrial Bax Translocation to Accomplish Resveratrol-Induced Apoptosis in the U937 Cell Line
[作者:Guha, P; Dey, A; Sen, R; Chatterjee, M; Chattopadhyay, S; Bandyopadhyay, SK,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:206-214 , 文章类型: Article,,卷期:2011年336-1]
- We have previously demonstrated that resveratrol (Resv)-induced cellular apoptosis occurs after formation of reactive oxygen species (ROS) but the role of GSH has not been well defined. Our experimental data enumerated t...
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