- Differential Signaling Defects Associated with the M201V Polymorphism in the Cysteinyl Leukotriene Type 2 Receptor
[作者:Brochu-Bourque, A; Veronneau, S; Rola-Pleszczynski, M; Stankova, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:431-439 , 文章类型: Article,,卷期:2011年336-2]
- The cysteinyl-leukotrienes (cysLTs) LTC4, LTD4, and LTE4, are involved in a variety of inflammatory diseases, including asthma, and act on at least two distinct receptors, CysLT(1) and CysLT(2). Specific antagonists of C...
- Airway Peroxidases Catalyze Nitration of the beta(2)-Agonist Salbutamol and Decrease Its Pharmacological Activity
[作者:Reszka, KJ; Sallans, L; Macha, S; Brown, K; McGraw, DW; Kovacic, MB; Britigan, BE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:440-449 , 文章类型: Article,,卷期:2011年336-2]
- beta(2)-Agonists are the most effective bronchodilators for the rapid relief of asthma symptoms, but for unclear reasons, their effectiveness may be decreased during severe exacerbations. Because peroxidase activity and ...
- Efficacy of Glutathione in Ameliorating Sulfur Mustard Analog-Induced Toxicity in Cultured Skin Epidermal Cells and in SKH-1 Mouse Skin In Vivo
[作者:Tewari-Singh, N; Agarwal, C; Huang, J; Day, BJ; White, CW; Agarwal, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:450-459 , 文章类型: Article,,卷期:2011年336-2]
- Exposure to chemical warfare agent sulfur mustard (HD) is reported to cause GSH depletion, which plays an important role in HD-linked oxidative stress and skin injury. Using the HD analog 2-chloroethyl ethyl sulfide (CEE...
- Characterization of the Covalent Binding of N-Phenyl-N '-(2-chloroethyl)ureas to beta-Tubulin: Importance of Glu198 in Microtubule Stability
[作者:Fortin, S; Bouchon, B; Chambon, C; Lacroix, J; Moreau, E; Chezal, JM; Degoul, F; C-Gaudreault, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:460-467 , 文章类型: Article,,卷期:2011年336-2]
- N-Phenyl-N'-(2-chloroethyl)ureas (CEUs) are antimicrotubule agents interacting covalently with beta-tubulin near the colchicine-binding site (C-BS). Glutamyl 198 residue in beta-tubulin (Glu198), which is adjacent to the...
- Pharmacological Characterization of KLYP961, a Dual Inhibitor of Inducible and Neuronal Nitric-Oxide Synthases
[作者:Symons, KT; Nguyen, PM; Massari, ME; Anzola, JV; Staszewski, LM; Wang, L; Yazdani, N; Dorow, S; Muhammad, J; Sablad, M; Rozenkrants, N; Bonefous, C; Payne, JE; Rix, PJ; Shiau, AK; Noble, SA; Smith, ND; Hassig, CA; Zhang, Y; Rao, TS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:468-478 , 文章类型: Article,,卷期:2011年336-2]
- Nitric oxide (NO) derived from neuronal nitric-oxide synthase (nNOS) and inducible nitric-oxide synthase (iNOS) plays a key role in various pain and inflammatory states. KLYP961 (4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin...
- Activation of Brain Histaminergic Neurotransmission: A Mechanism for Cognitive Effects of Memantine in Alzheimer's Disease
[作者:Motawaj, M; Burban, A; Davenas, E; Arrang, JM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:479-487 , 文章类型: Article,,卷期:2011年336-2]
- We previously reported that some N-methyl-D-aspartate (NMDA)-receptor antagonists enhanced histamine neuron activity in rodents. Here, we have investigated the effects of memantine, an NMDA-receptor antagonist used for t...
- Anticancer Efficacy of Simvastatin on Prostate Cancer Cells and Tumor Xenografts Is Associated with Inhibition of Akt and Reduced Prostate-Specific Antigen Expression
[作者:Kochuparambil, ST; Al-Husein, B; Goc, A; Soliman, S; Somanath, PR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:496-505 , 文章类型: Article,,卷期:2011年336-2]
- Prostate cancer is the second-leading cause of cancer-associated death among men in the United States. There has been renewed interest in the potential therapeutic benefits of statins for cancer. Simvastatin, a widely us...
- The Distribution of Nifurtimox Across the Healthy and Trypanosome-Infected Murine Blood-Brain and Blood-Cerebrospinal Fluid Barriers
[作者:Jeganathan, S; Sanderson, L; Dogruel, M; Rodgers, J; Croft, S; Thomas, SA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:506-515 , 文章类型: Article,,卷期:2011年336-2]
- Nifurtimox, an antiparasitic drug, is used to treat American trypanosomiasis (Chagas disease) and has shown promise in treating central nervous system (CNS)-stage human African trypanosomiasis (HAT; sleeping sickness). I...
- The Effects of the Stromal Cell-Derived Cyclooxygenase-2 Metabolite Prostaglandin E-2 on the Proliferation of Colon Cancer Cells
[作者:Park, SW; Kim, HS; Choi, MS; Jeong, WJ; Heo, DS; Kim, KH; Sung, MW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:516-523 , 文章类型: Article,,卷期:2011年336-2]
- It is well known that tumor-surrounding stromal tissues support tumor development through secreting soluble factors such as various cytokines, chemokines, and growth factors. It has also been suggested that tumor-associa...
- beta(2)-Adrenergic Receptor Agonists Inhibit the Proliferation of 1321N1 Astrocytoma Cells
[作者:Toll, L; Jimenez, L; Waleh, N; Jozwiak, K; Woo, AYH; Xiao, RP; Bernier, M; Wainer, IW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:524-532 , 文章类型: Article,,卷期:2011年336-2]
- Astrocytomas and glioblastomas have been particularly difficult to treat and refractory to chemotherapy. However, significant evidence has been presented that demonstrates a decrease in astrocytoma cell proliferation sub...
- Endothelin ETB Receptor Is Involved in Sex Differences in the Development of Balloon Injury-Induced Neointimal Formation
[作者:Kitada, K; Yui, N; Koyama, M; Kimura, K; Suzuki, R; Tanaka, R; Mori, T; Ohkita, M; Matsumura, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:533-539 , 文章类型: Article,,卷期:2011年336-2]
- The purpose of this study was to evaluate the involvement of endothelin (ET)(B) receptor-mediated action in the sex differences in balloon injury-induced neointimal formation using the spotting-lethal rat, which carries ...
- Modulation of the Glucagon-Like Peptide-1 Receptor Signaling by Naturally Occurring and Synthetic Flavonoids
[作者:Wootten, D; Simms, J; Koole, C; Woodman, OL; Summers, RJ; Christopoulos, A; Sexton, PM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:540-550 , 文章类型: Article,,卷期:2011年336-2]
- The glucagon-like peptide 1 receptor (GLP-1R) is a promising target for the treatment of type II diabetes mellitus because of its role in metabolic homeostasis. In recent years, difficulties with peptide therapies have d...
- Mechanisms of Amiodarone and Desethylamiodarone Cytotoxicity in Nontransformed Human Peripheral Lung Epithelial Cells
[作者:Mulder, JE; Brien, JF; Racz, WJ; Takahashi, T; Massey, TE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:551-559 , 文章类型: Article,,卷期:2011年336-2]
- Amiodarone (AM) is a potent antidysrhythmic agent that can cause potentially life-threatening pulmonary fibrosis, and N-desethylamiodarone (DEA), an AM metabolite, may contribute to AM toxicity. Apoptotic cell death in n...
- The GluK1 (GluR5) Kainate/alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonist LY293558 Reduces Soman-Induced Seizures and Neuropathology
[作者:Figueiredo, TH; Qashu, F; Apland, JP; Aroniadou-Anderjaska, V; Souza, AP; Braga, MFM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:303-312 , 文章类型: Article,,卷期:2011年336-2]
- The possibility of mass exposure to nerve agents by a terrorist attack necessitates the availability of antidotes that can be effective against nerve agent toxicity even when administered at a relatively long latency aft...
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