- Effect of Methamphetamine Self-Administration on Neurotensin Systems of the Basal Ganglia
[作者:Frankel, PS; Hoonakker, AJ; Alburges, ME; McDougall, JW; McFadden, LM; Fleckenstein, AE; Hanson, GR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:809-815 , 文章类型: Article,,卷期:2011年336-3]
- Methamphetamine (METH) dependence causes alarming personal and social damage. Even though many of the problems associated with abuse of METH are related to its profound actions on dopamine (DA) basal ganglia systems, the...
- Differential Effect of Meclizine on the Activity of Human Pregnane X Receptor and Constitutive Androstane Receptor
[作者:Lau, AJ; Yang, GX; Rajaraman, G; Baucom, CC; Chang, TKH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:816-826 , 文章类型: Article,,卷期:2011年336-3]
- Conflicting data exist as to whether meclizine is an activator of human pregnane X receptor (hPXR). Therefore, we conducted a detailed, systematic investigation to determine whether meclizine affects hPXR activity by per...
- JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Suppresses Food Intake and Gastric Emptying with the Elevation of Plasma Peptide YY and Glucagon-Like Peptide-1 in a Dietary Fat-Dependent Manner
[作者:Hata, T; Mera, Y; Ishii, Y; Tadaki, H; Tomimoto, D; Kuroki, Y; Kawai, T; Ohta, T; Kakutani, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:850-856 , 文章类型: Article,,卷期:2011年336-3]
- The microsomal triglyceride transfer protein (MTP) takes part in the mobilization and secretion of triglyceride-rich lipoproteins from enterocytes and hepatocytes. In this study, we investigated the effects of diethyl-2-...
- The Posterior Ventral Tegmental Area Mediates Alcohol-Seeking Behavior in Alcohol-Preferring Rats
[作者:Hauser, SR; Ding, ZM; Getachew, B; Toalston, JE; Oster, SM; McBride, WJ; Rodd, ZA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:857-865 , 文章类型: Article,,卷期:2011年336-3]
- The mesolimbic dopamine (DA) system is involved in the rewarding process of drugs of abuse and is activated during the anticipation of drug availability. However, the neurocircuitry that regulates ethanol (EtOH)-seeking ...
- Antitumoral Alkylphospholipids Induce Cholesterol Efflux from the Plasma Membrane in HepG2 Cells
[作者:Rios-Marco, P; Jimenez-Lopez, JM; Marco, C; Segovia, JL; Carrasco, MP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:866-873 , 文章类型: Article,,卷期:2011年336-3]
- Alkylphospholipid (APL) analogs are promising candidates in the search for treatments of cancer. Previous studies conducted in our laboratory indicate that, after prolonged treatment, they alter cholesterol homeostasis i...
- A New Nonpeptidic Inhibitor of 14-3-3 Induces Apoptotic Cell Death in Chronic Myeloid Leukemia Sensitive or Resistant to Imatinib
[作者:Mancini, M; Corradi, V; Petta, S; Barbieri, E; Manetti, F; Botta, M; Santucci, MA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:596-604 , 文章类型: Article,,卷期:2011年336-3]
- Resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitor imatinib mesylate (IM) is most often due to point mutations in the Bcr-Abl fusion gene. T315I mutation (resulting in substitution of Ile for a Thr...
- Evidence That Botulinum Toxin Receptors on Epithelial Cells and Neuronal Cells Are Not Identical: Implications for Development of a Non-Neurotropic Vaccine
[作者:Elias, M; al-Saleem, F; Ancharski, DM; Singh, A; Nasser, Z; Olson, RM; Simpson, LL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:605-612 , 文章类型: Article,,卷期:2011年336-3]
- Botulinum toxin typically interacts with two types of cells to cause the disease botulism. The toxin initially interacts with epithelial cells in the gut or airway to undergo binding, transcytosis, and delivery to the ge...
- Evaluation of a Stable Gonadotropin-Releasing Hormone Analog in Mice for the Treatment of Endocrine Disorders and Prostate Cancer
[作者:Katsila, T; Balafas, E; Liapakis, G; Limonta, P; Marelli, MM; Gkountelias, K; Tselios, T; Kostomitsopoulos, N; Matsoukas, J; Tamvakopoulos, C,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:613-623 , 文章类型: Article,,卷期:2011年336-3]
- Gonadotropin-releasing hormone (GnRH) receptor agonists have wide clinical applications including the treatment of prostate cancer and endocrine disorders. However, such agonists are characterized by poor pharmacokinetic...
- Allosteric Modulation of Related Ligand-Gated Ion Channels Synergistically Induces Long-Term Potentiation in the Hippocampus and Enhances Cognition
[作者:Johnstone, TB; Gu, ZL; Yoshimura, RF; Villegier, AS; Hogenkamp, DJ; Whittemore, ER; Huang, JC; Tran, MB; Belluzzi, JD; Yakel, JL; Gee, KW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:908-915 , 文章类型: Article,,卷期:2011年336-3]
- alpha 5 Subunit-containing GABA(A) receptors (GABA(A)Rs) and alpha 7 neuronal nicotinic-acetylcholine receptors (nAChRs) are members of the Cys-loop family of ligand-gated ion channels (LGICs) that mediate cognitive and ...
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