- Regulation of XIAP Translation and Induction by MDM2 following Irradiation
[作者：Gu, LB; Zhu, NX; Zhang, HY; Durden, DL; Feng, Y; Zhou, MX,期刊：Cancer Cell, 页码：363-375 , 文章类型： Article，,卷期：2009年15-5]
- Increases in protein levels of XIAP in cancer cells have been associated with resistance to apoptosis induced by cellular stress. Herein we demonstrate that the upregulation of XIAP protein levels is regulated by MDM2 at...
- PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain
[作者：Lambert, JMR; Gorzov, P; Veprintsev, DB; Soderqvist, M; Segerback, D; Bergman, J; Fersht, AR; Hainaut, P; Wiman, KG; Bykov, VJN,期刊：Cancer Cell, 页码：376-388 , 文章类型： Article，,卷期：2009年15-5]
- Restoration of wild-type p53 expression triggers cell death and eliminates tumors in vivo. The identification of mutant p53-reactivating small molecules such as PRIMA-1 opens possibilities for the development of more eff...
- CDK Inhibitor p18(INK4c) Is a Downstream Target of GATA3 and Restrains Mammary Luminal Progenitor Cell Proliferation and Tumorigenesis
[作者：Pei, XH; Bai, F; Smith, MD; Usary, J; Fan, C; Pai, SY; Ho, IC; Perou, CM; Xiong, Y,期刊：Cancer Cell, 页码：389-401 , 文章类型： Article，,卷期：2009年15-5]
- Mammary epithelia are composed of luminal and myoepithelial/basal cells whose neoplastic transformations lead to distinct types of breast cancers with diverse clinical features. We report that mice deficient for the CDK4...
- Translational Activation of Snail1 and Other Developmentally Regulated Transcription Factors by YB-1 Promotes an Epithelial-Mesenchymal Transition
[作者：Evdokimova, V; Tognon, C; Ng, T; Ruzanov, P; Melnyk, N; Fink, D; Sorokin, A; Ovchinnikov, LP; Davicioni, E; Triche, TJ; Sorensen, PHB,期刊：Cancer Cell, 页码：402-415 , 文章类型： Article，,卷期：2009年15-5]
- Increased expression of the transcription/translation regulatory protein Y-box binding protein-1 (YB-1) is associated with cancer aggressiveness, particularly in breast carcinoma. Here we establish that YB-1 levels are e...
- Stabilization of Snail by NF-kappa B Is Required for Inflammation-Induced Cell Migration and Invasion
[作者：Wu, Y; Deng, J; Rychahou, PG; Qiu, SM; Evers, BM; Zhou, BPH,期刊：Cancer Cell, 页码：416-428 , 文章类型： Article，,卷期：2009年15-5]
- The increased motility and invasiveness of tumor cells are reminiscent of epithelial-mesenchymal transition (EMT), which occurs during embryonic development, wound healing, and metastasis. In this study, we found that Sn...
- Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941
[作者：Junttila, TT; Akita, RW; Parsons, K; Fields, C; Phillips, GDL; Friedman, LS; Sampath, D; Sliwkowski, MX,期刊：Cancer Cell, 页码：429-440 , 文章类型： Article，,卷期：2009年15-5]
- Herceptin (trastuzumab) is the backbone of HER2-directed breast cancer therapy and benefits patients in both the adjuvant and metastatic settings. Here, we describe a mechanism of action for trastuzumab whereby antibody ...
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