- CD4(+) T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages
[作者：DeNardo, DG; Barreto, JB; Andreu, P; Vasquez, L; Tawfik, D; Kolhatkar, N; Coussens, LM,期刊：Cancer Cell, 页码：91-102 , 文章类型： Article，,卷期：2009年16-2]
- During breast cancer development, increased presence of leukocytes in neoplastic stroma parallels disease progression; however, the functional significance of leukocytes in regulating protumor versus antitumor immunity i...
- Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma Cells
[作者：Tormo, D; Checinska, A; Alonso-Curbelo, D; Perez-Guijarro, E; Canon, E; Riveiro-Falkenbach, E; Calvo, TG; Larribere, L; Megias, D; Mulero, F; Piris, MA; Dash, R; Barral, PM; Rodriguez-Peralto, JL; Ortiz-Romero, P; Tuting, T; Fisher, PB; Soengas, MS,期刊：Cancer Cell, 页码：103-114 , 文章类型： Article，,卷期：2009年16-2]
Inappropriate drug delivery, secondary toxicities, and persistent chemo- and immunoresistance have traditionally compromised treatment response in melanoma. Using cellular systems and genetically engineered mouse mode...
- Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling
[作者：Gewinner, C; Wang, ZGC; Richardson, A; Teruya-Feldstein, J; Etemadmoghadam, D; Bowtell, D; Barretina, J; Lin, WM; Rameh, L; Salmena, L; Pandolfi, PP; Cantley, LC,期刊：Cancer Cell, 页码：115-125 , 文章类型： Article，,卷期：2009年16-2]
- We report that knocking down the expression of inositol polyphosphate 4-phosphatase type II (INPP4B) in human epithelial cells, like knockdown of PTEN, resulted in enhanced Akt activation and anchorage-independent growth...
- Persistence of Leukemia-Initiating Cells in a Conditional Knockin Model of an Imatinib-Responsive Myeloproliferative Disorder
[作者：Oravecz-Wilson, KI; Philips, ST; Yilmaz, OH; Ames, HM; Li, L; Crawford, BD; Gauvin, AM; Lucas, PC; Sitwala, K; Downing, JR; Morrison, SJ; Ross, TS,期刊：Cancer Cell, 页码：137-148 , 文章类型： Article，,卷期：2009年16-2]
- Despite remarkable responses to the tyrosine kinase inhibitor imatinib, CML patients are rarely cured by this therapy perhaps due to imatinib refractoriness of leukemia-initiating cells (LICs). Evidence for this is limit...
- Raf-1 Addiction in Ras-Induced Skin Carcinogenesis
[作者：Ehrenreiter, K; Kern, F; Velamoor, V; Meissl, K; Galabova-Kovacs, G; Sibilia, M; Baccarini, M,期刊：Cancer Cell, 页码：149-160 , 文章类型： Article，,卷期：2009年16-2]
- Ras activation is common to many human cancers and promotes cell proliferation and survival by initiating multiple signaling cascades. Accordingly, Ras-transformed cells are generally considered too resourceful to become...
- Tumor Suppression by Phospholipase C-beta 3 via SHP-1-Mediated Dephosphorylation of Stat5
[作者：Xiao, WB; Hong, H; Kawakami, Y; Kato, Y; Wu, DQ; Yasudo, H; Kimura, A; Kubagawa, H; Bertoli, LF; Davis, RS; Chau, LA; Madrenas, J; Hsia, CC; Xenocostas, A; Kipps, TJ; Hennighausen, L; Iwama, A; Nakauchi, H; Kawakami, T,期刊：Cancer Cell, 页码：161-171 , 文章类型： Article，,卷期：2009年16-2]
- Given its catalytic activity to generate diacylglycerol and inositol 1,4,5-trisphosphate, phospholipase C (PLC) is implicated in promoting cell growth. However, we found that PLC-beta 3-deficient mice develop myeloprolif...
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