- Proteomic Profiling of the Human Cytomegalovirus UL35 Gene Products Reveals a Role for UL35 in the DNA Repair Response
[作者:Salsman, J; Jagannathan, M; Paladino, P; Chan, PK; Dellaire, G; Raught, B; Frappier, L,期刊:Journal of virology, 页码:806-820 , 文章类型: Article,,卷期:2012年86-2]
- Human cytomegalovirus infections involve the extensive modification of host cell pathways, including cell cycle control, the regulation of the DNA damage response, and averting promyelocytic leukemia (PML)-mediated antiv...
- High-Resolution Analysis of Intrahost Genetic Diversity in Dengue Virus Serotype 1 Infection Identifies Mixed Infections
[作者:Thai, KTD; Henn, MR; Zody, MC; Tricou, V; Nguyet, NM; Charlebois, P; Lennon, NJ; Green, L; de Vries, PJ; Hien, TT; Farrar, J; van Doorn, HR; de Jong, MD; Birren, BW; Holmes, EC; Simmons, CP,期刊:Journal of virology, 页码:835-843 , 文章类型: Article,,卷期:2012年86-2]
- Little is known about the rate at which genetic variation is generated within intrahost populations of dengue virus (DENV) and what implications this diversity has for dengue pathogenesis, disease severity, and host immu...
- Molecular Determinants of Severe Acute Respiratory Syndrome Coronavirus Pathogenesis and Virulence in Young and Aged Mouse Models of Human Disease
[作者:Frieman, M; Yount, B; Agnihothram, S; Page, C; Donaldson, E; Roberts, A; Vogel, L; Woodruff, B; Scorpio, D; Subbarao, K; Baric, RS,期刊:Journal of virology, 页码:884-897 , 文章类型: Article,,卷期:2012年86-2]
- SARS coronavirus (SARS-CoV) causes severe acute respiratory tract disease characterized by diffuse alveolar damage and hyaline membrane formation. This pathology often progresses to acute respiratory distress (such as ac...
- Cloning and Analysis of Sooty Mangabey Alternative Coreceptors That Support Simian Immunodeficiency Virus SIVsmm Entry Independently of CCR5
[作者:Elliott, STC; Riddick, NE; Francella, N; Paiardini, M; Vanderford, TH; Li, B; Apetrei, C; Sodora, DL; Derdeyn, CA; Silvestri, G; Collman, RG,期刊:Journal of virology, 页码:898-908 , 文章类型: Article,,卷期:2012年86-2]
- Natural host sooty mangabeys (SM) infected with simian immunodeficiency virus SIVsmm do not develop AIDS despite high viremia. SM and other natural hosts express very low levels of CCR5 on CD4(+) T cells, and we recently...
- HLA-B(star)57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control
[作者:Kloverpris, HN; Stryhn, A; Harndahl, M; van der Stok, M; Payne, RP; Matthews, PC; Chen, FB; Riddell, L; Walker, BD; Ndung'u, T; Buus, S; Goulder, P,期刊:Journal of virology, 页码:919-929 , 文章类型: Article,,卷期:2012年86-2]
- The genetic polymorphism that has the greatest impact on immune control of human immunodeficiency virus (HIV) infection is expression of HLA-B(star)57. Understanding of the mechanism for this strong effect remains incomp...
- Potent Autologous and Heterologous Neutralizing Antibody Responses Occur in HIV-2 Infection across a Broad Range of Infection Outcomes
[作者:de Silva, TI; Aasa-Chapman, M; Cotten, M; Hue, S; Robinson, J; Bibollet-Ruche, F; Sarge-Njie, R; Berry, N; Jaye, A; Aaby, P; Whittle, H; Rowland-Jones, S; Weiss, R,期刊:Journal of virology, 页码:930-946 , 文章类型: Article,,卷期:2012年86-2]
- Few studies have explored the role of neutralizing antibody (NAb) responses in controlling HIV-2 viremia and disease progression. Using a TZM-bl neutralization assay, we assessed heterologous and autologous NAb responses...
- Polyfunctional T Cells Accumulate in Large Human Cytomegalovirus-Specific T Cell Responses
[作者:Lachmann, R; Bajwa, M; Vita, S; Smith, H; Cheek, E; Akbar, A; Kern, F,期刊:Journal of virology, 页码:1001-1009 , 文章类型: Article,,卷期:2012年86-2]
- Large cytomegalovirus (CMV)-specific CD8 T-cell responses are observed in both young and, somewhat more often, old people. Frequent CMV reactivation is thought to exhaust these cells and render them dysfunctional so that...
- Epigenetic Changes Mediated by MicroRNA miR29 Activate Cyclooxygenase 2 and Lambda-1 Interferon Production during Viral Infection
[作者:Fang, JL; Hao, Q; Liu, L; Li, YK; Wu, JG; Huo, XX; Zhu, Y,期刊:Journal of virology, 页码:1010-1020 , 文章类型: Article,,卷期:2012年86-2]
- Lambda-1 interferon (IFN-lambda 1) and cyclooxygenase-2 (COX-2) were reported to play an important role in host antiviral defense. However, the mechanism by which IFN-lambda 1 and COX2 are activated and modulated during ...
- Contributions of CTCF and DNA Methyltransferases DNMT1 and DNMT3B to Epstein-Barr Virus Restricted Latency
[作者:Hughes, DJ; Marendy, EM; Dickerson, CA; Yetming, KD; Sample, CE; Sample, JT,期刊:Journal of virology, 页码:1034-1045 , 文章类型: Article,,卷期:2012年86-2]
- Establishment of persistent Epstein-Barr virus (EBV) infection requires transition from a program of full viral latency gene expression (latency III) to one that is highly restricted (latency I and 0) within memory B lym...
- Activation of NF-kappa B in CD8(+) Dendritic Cells Ex Vivo by the gamma(1)34.5 Null Mutant Correlates with Immunity against Herpes Simplex Virus 1
[作者:Jin, HL; Ma, YJ; Yan, ZP; Prabhakar, BS; He, B,期刊:Journal of virology, 页码:1059-1068 , 文章类型: Article,,卷期:2012年86-2]
- The gamma(1)34.5 protein of herpes simplex viruses (HSV) is essential for virulence. Accordingly, an HSV mutant lacking gamma(1)34.5 is attenuated in vivo. Despite its vaccine potential, the mechanism by which the gamma(...
- Broad and Potent Neutralizing Antibody Responses Elicited in Natural HIV-2 Infection
[作者:Kong, R; Li, H; Bibollet-Ruche, F; Decker, JM; Zheng, NN; Gottlieb, GS; Kiviat, NB; Sow, PS; Georgiev, I; Hahn, BH; Kwong, PD; Robinson, JE; Shaw, GM,期刊:Journal of virology, 页码:947-960 , 文章类型: Article,,卷期:2012年86-2]
- Compared with human immunodeficiency virus type 1 (HIV-1), little is known about the susceptibility of HIV-2 to antibody neutralization. We characterized the potency and breadth of neutralizing antibody (NAb) responses i...
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