Background: The sirtuin family of deacetylase enzymes comprises seven proteins (SIRT1-7) that are dependent on NAD+ for their activity. Three proteins are located in the nucleus, three in the mitochondria and only one...

Monocyte chemoattractant protein-1 (MCP-1) is a major chemoattractant for monocytes and memory T cells by means of their binding to its specific cell-surface receptor, CC-chemokine receptor-2 (CCR2). CCR2 belongs to t...

Background: Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins. Trks play important roles in pain sensation as well as tumour cell growth and survival signaling. Th...

Background: Aurora-A, Aurora-B and Aurora-C, members of serine/threonine kinase family, play an important role in mitosis. They are essential for spindle assembly, centrosome maturation, chromosomal segregation and cy...

Background: Severe acute respiratory syndrome (SARS) coronavirus emerged fleetingly in the winter of 2002 and again in the winter of 2003, resulting in the infection of similar to 8000 people and the death of similar ...

Background: Embryonic stem cells are pluripotent cells that can differentiate to any cell type. Stem-cell research promises great progress in regenerative medicine to replace damaged tissues and organs. Objective: The...

Background: Imidazothiazoles are well-known compounds and many derivatives of this fused ring system have been evaluated for potential biological activity. Objectives: The present application is focused on imidazo[2,1...

Background: The application is in the field of stem cells and their therapeutic application for the treatment of inflammation. Objective: It aims at characterizing the potential of adult-derived neural progenitor and ...

Background: The application is in the field of neural stem cells (NSCs) and cellular therapy. Objective: It aims at establishing conditions for the isolation and propagation of neural progenitor and stem cells from hu...