The application is in the field of adult neurogenesis and its therapeutic potential. It aims to characterize the activity of apigenin and related compounds on adult neurogenesis in vivo and in vitro. Apigenin and rela...

The application, WO2008062379, claims chimeric compounds comprising chemically linked 5-hydroxymethyl-oxazolidinone and tetracyclic-quinolone moieties. The claimed compounds are potent expanded-range antibacterial age...

The application is in the field of adult neurogenesis and neuronal degeneration and regeneration. It aims to characterize the activity of 15 compounds and their derivatives on adult neurogenesis, apoptosis, necrosis a...

These two patent applications describe a subset of compounds previously claimed generically. Although both represent potentially exciting novel structural types, not previously associated with glucokinase activation, ...

Background: Sirtuin 1 - 7 (SIRT1 - 7) are deacetylases that are dependent on NAD+ for their activity. SIRT1 down-regulates p53 activity, increasing lifespan, cell survival, and neuroprotection; it also deacetylates pe...

Background: Severe acute respiratory syndrome (SARS) coronavirus emerged from an animal reservoir in 2002 and has the potential to reemerge, as shown by the occurrence of non-laboratory-associated new cases in the win...

Background: Mechanisms of neuroprotection encompass energy deficits in brain arising from insufficient oxygen and glucose levels following respiratory failure; ischemia or stroke, which produce metabolic stresses that...

Background: Plants synthesise a vast repertoire of chemicals with various biological activities. Brazilian enormous botanical diversity facilitates the development of novel ethical drugs for the treatment of diseases ...

Background: The development of RNA interference (RNAi)-based gene silencing approaches has revolutionized biomedical research. These technologies have been applied for functional genomic studies in a variety of areas,...

Background: Stimuli-responsive materials that undergo dramatic changes in physical-chemical properties in response to mild physical changes in environmental conditions are attracting increasing interest because of the...