- Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival
[作者：Zhou, XL; Wang, JL; Lu, J; Song, YP; Kwak, KS; Jiao, QS; Rosenfeld, R; Chen, Q; Boone, T; Simonet, WS; Lacey, DL; Goldberg, AL; Han, HQ,期刊：Cell, 页码：531-543 , 文章类型： Article，,卷期：2010年142-4]
- Muscle wasting and cachexia have long been postulated to be key determinants of cancer-related death, but there has been no direct experimental evidence to substantiate this hypothesis. Here, we show that in several canc...
- PcrA Helicase Dismantles RecA Filaments by Reeling in DNA in Uniform Steps
[作者：Park, J; Myong, S; Niedziela-Majka, A; Lee, KS; Yu, J; Lohman, TM; Ha, T,期刊：Cell, 页码：544-555 , 文章类型： Article，,卷期：2010年142-4]
- Translocation of helicase-like proteins on nucleic acids underlies key cellular functions. However, it is still unclear how translocation can drive removal of DNA-bound proteins, and basic properties like the elementary ...
- The Monopolin Complex Crosslinks Kinetochore Components to Regulate Chromosome-Microtubule Attachments
[作者：Corbett, KD; Yip, CK; Ee, LS; Walz, T; Amon, A; Harrison, SC,期刊：Cell, 页码：556-567 , 文章类型： Article，,卷期：2010年142-4]
- The monopolin complex regulates different types of kinetochore-microtubule attachments in fungi, ensuring sister chromatid co-orientation in Saccharomyces cerevisiae meiosis I and inhibiting merotelic attachment in Schiz...
- ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death
[作者：Radoshevich, L; Murrow, L; Chen, N; Fernandez, E; Roy, S; Fung, C; Debnath, J,期刊：Cell, 页码：590-600 , 文章类型： Article，,卷期：2010年142-4]
- ATG12, an ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, another autophagy regulator called ATG5. Here, we identify ATG3 as a substrate for ATG12 conjugation. ATG3 is the E2-l...
- Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity
[作者：van Ham, TJ; Holmberg, MA; van der Goot, AT; Teuling, E; Garcia-Arencibia, M; Kim, HE; Du, D; Thijssen, KL; Wiersma, M; Burggraaff, R; van Bergeijk, P; van Rheenen, J; van Veluw, GJ; Hofstra, RMW; Rubinsztein, DC; Nollen, EAA,期刊：Cell, 页码：601-612 , 文章类型： Article，,卷期：2010年142-4]
- Fibrillar protein aggregates are the major pathological hallmark of several incurable, age-related, neurodegenerative disorders. These aggregates typically contain aggregation-prone pathogenic proteins, such as amyloid-b...
- Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress
[作者：Seifert, U; Bialy, LP; Ebstein, F; Bech-Otschir, D; Voigt, A; Schroter, F; Prozorovski, T; Lange, N; Steffen, J; Rieger, M; Kuckelkorn, U; Aktas, O; Kloetzel, PM; Kruger, E,期刊：Cell, 页码：613-624 , 文章类型： Article，,卷期：2010年142-4]
- Interferon (IFN)-induced immunoproteasomes (i-proteasomes) have been associated with improved processing of major histocompatibility complex (MHC) class I antigens. Here, we show that i-proteasomes function to protect ce...
- Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease
[作者：Gray, DC; Mahrus, S; Wells, JA,期刊：Cell, 页码：637-646 , 文章类型： Article，,卷期：2010年142-4]
- Apoptosis is a conserved cellular pathway that results in the activation of cysteine-aspartyl proteases, or caspases. To dissect the nonredundant roles of the executioner caspase-3, -6, and -7 in orchestrating apoptosis,...
- Cell Culture
[作者：Doucleff, M,期刊：Cell, 页码：501-503 , 文章类型： Editorial Material，,卷期：2010年142-4]
- Summer time is vacation time-a chance to step away from minipreps or grant deadlines and investigate nature outside the lab. For many of us, that means a trip to the beach. But don't let those colorful umbrellas and vigi...
- Induced Domain Formation in Endocytic Invagination, Lipid Sorting, and Scission
[作者：Johannes, L; Mayor, S,期刊：Cell, 页码：507-510 , 文章类型： Article，,卷期：2010年142-4]
- Lipid segregation occurs in biological membranes, but how this plays into cellular processes like endocytosis has been unclear. Here, we discuss how the active or passive induction of lipid-protein domain formation in me...
- Reversing Cachexia
[作者：Tisdale, MJ,期刊：Cell, 页码：511-512 , 文章类型： Editorial Material，,卷期：2010年142-4]
- Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (Act...
- The Ins and Outs of EGFR Asymmetry
[作者：Leahy, DJ,期刊：Cell, 页码：513-515 , 文章类型： Editorial Material，,卷期：2010年142-4]
- The epidermal growth factor receptor (EGFR) regulates cell proliferation in many tissues. A new structure of the Drosophila EGFR presented by Alvarado et al. (2010) reveals an asymmetric dimer with the ligand bound to on...
- Up a Hydrophobic Creek with a Short Paddle
[作者：Hulse, RE; Li, QF; Perozo, E,期刊：Cell, 页码：515-516 , 文章类型： Editorial Material，,卷期：2010年142-4]
- The mechanism by which voltage-dependent ion channels sense membrane potentials has been the most intensively studied and debated topic in modern ion channel research. In this issue, Xu et al. (2010) provide new insights...
- The Immunoproteasome Cleans up after Inflammation
[作者：van Deventer, S; Neefjes, J,期刊：Cell, 页码：517-518 , 文章类型： Editorial Material，,卷期：2010年142-4]
- Immune cells and cells activated by the inflammatory cytokine interferon express variant proteasomes called immunoproteasomes that are characterized by unique catalytic subunits. Seifert et al. (2010) now show in mouse m...
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