- Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation
[作者:Nishikata, I; Nakahata, S; Saito, Y; Kaneda, K; Ichihara, E; Yamakawa, N; Morishita, K,期刊:Oncogene, 页码:4194-4207 , 文章类型: Article,,卷期:2011年30-40]
- MEL1 (MDS1/EVI1-like gene 1/PRDM16), which was identified as a gene near the chromosomal breakpoint in t(1;3)(p36;q21)-positive human acute myeloid leukemia cells, belongs to the (P) under bar RDI-BF1-(R) under bar IZ1 h...
- Molecular imaging of tumor metabolism and apoptosis
[作者:Haberkorn, U; Markert, A; Mier, W; Askoxylakis, V; Altmann, A,期刊:Oncogene, 页码:4141-4151 , 文章类型: Review,,卷期:2011年30-40]
- Increased metabolism in a number of cellular pathways is a common feature of malignant tumors. This metabolic hallmark of neoplastic tissue led to the development of radiopharmaceuticals for the assessment of transport a...
- MSX2 is an oncogenic downstream target of activated WNT signaling in ovarian endometrioid adenocarcinoma
[作者:Zhai, Y; Iura, A; Yeasmin, S; Wiese, AB; Wu, R; Feng, Y; Fearon, ER; Cho, KR,期刊:Oncogene, 页码:4152-4162 , 文章类型: Article,,卷期:2011年30-40]
- Ovarian endometrioid adenocarcinomas (OEAs) frequently exhibit constitutive activation of canonical WNT signaling, usually as a result of oncogenic mutations that stabilize and dysregulate the beta-catenin protein. In pr...
- Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition
[作者:Rexer, BN; Ham, AJL; Rinehart, C; Hill, S; Granja-Ingram, ND; Gonzalez-Angulo, AM; Mills, GB; Dave, B; Chang, JC; Liebler, DC; Arteaga, CL,期刊:Oncogene, 页码:4163-4174 , 文章类型: Article,,卷期:2011年30-40]
- Despite the initial effectiveness of the tyrosine kinase inhibitor lapatinib against HER2 gene-amplified breast cancers, most patients eventually relapse after treatment, implying that tumors acquire mechanisms of drug r...
- Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response
[作者:Lee, YH; Judge, AD; Seo, D; Kitade, M; Gomez-Quiroz, LE; Ishikawa, T; Andersen, JB; Kim, BK; Marquardt, JU; Raggi, C; Avital, I; Conner, EA; MacLachlan, I; Factor, VM; Thorgeirsson, SS,期刊:Oncogene, 页码:4175-4184 , 文章类型: Article,,卷期:2011年30-40]
- Development of targeted therapy for hepatocellular carcinoma (HCC) remains a major challenge. We have recently identified an elevated expression of the fifth subunit of COP9 signalosome (CSN5) in early HCC as compared wi...
- LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms
[作者:King, CE; Wang, L; Winograd, R; Madison, BB; Mongroo, PS; Johnstone, CN; Rustgi, AK,期刊:Oncogene, 页码:4185-4193 , 文章类型: Article,,卷期:2011年30-40]
- Lin28b is an RNA-binding protein that inhibits biogenesis of let-7 microRNAs. LIN28B is overexpressed in diverse cancers, yet a specific role in the molecular pathogenesis of colon cancer has to be elucidated. We have de...
|