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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共24条记录   High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase [作者：CHENG TINGJEN RACHEL; WU YINGTA; YANG SHIHTING; LO KIENHOCK; CHEN SHAOKANG; CHEN YINHSUAN; HUANG WENI; YUAN CHIHHUNG; GUO CHIHWEI; HUANG LINYA; CHEN KUOTING; SHIH HAOWEI; CHENG YIHSHYUN E; CHENG WEICHIEH; WONG CHIHUEY,期刊：Bioorganic & Medicinal Chemistry, 页码：8512-8529 , 文章类型： Article，,卷期：2010年18-24] To identify new transglycosylase inhibitors with potent anti-methicillin-resistant Staphylococcus aureus (MRSA) activities, a high-throughput screening against Staphylococcus aureus was conducted to look for antibacteria... abeo-Abietanes from Teucrium polium roots as protective factors against oxidative stress [作者：FIORENTINO ANTONIO; DABROSCA BRIGIDA; PACIFICO SEVERINA; SCOGNAMIGLIO MONICA; DANGELO GRAZIA; MONACO PIETRO,期刊：Bioorganic & Medicinal Chemistry, 页码：8530-8536 , 文章类型： Article，,卷期：2010年18-24] Six new 17(15 -> 16)-abeo-abietanes, along with seven known compounds, were isolated and characterized from ethyl acetate root extract of Teucrium polium L., a medicinal plant belonging to the Labiatae family reported to... Novel lipophilic 7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid derivatives as potential antitumor agents: Improved synthesis and in vitro evaluation [作者：KOROLYOV ALEXANDER; DORBES SANDRA; AZEMA JOELLE; GUIDETTI BRIGITTE; DANEL MATHIEU; LAMORALTHEYS DELPHINE; GRAS THIERRY; DUBOIS JACQUES; KISS ROBERT; MARTINO ROBERT; MALETMARTINO MYRIAM,期刊：Bioorganic & Medicinal Chemistry, 页码：8537-8548 , 文章类型： Article，,卷期：2010年18-24] A convenient route for the synthesis of some acyloxymethyl esters and carboxamides of levofloxacin (LV) with modulated lipophilicity is described. The synthesized compounds were evaluated in vitro for their growth inhibi... Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials [作者：PAVLOVIC DRAZEN; FAJDETIC ANDREA; MUTAK STJEPAN,期刊：Bioorganic & Medicinal Chemistry, 页码：8566-8582 , 文章类型： Article，,卷期：2010年18-24] A series of novel 6-O-substituted and 6,12-di-O-substituted 8a-aza-8a-homoerythromycin A and 9a-aza-9a-homoerythromycin A ketolides were synthesized and evaluated for in vitro antibacterial activity against a panel of re... A novel PET marker for in vivo quantification of myelination [作者：WU CHUNYING; WANG CHANGNING; POPESCU DANIELA C; ZHU WENXIA; SOMOZA EDUARDO A; ZHU JUNQING; CONDIE ALLISON G; FLASK CHRISTOPHER A; MILLER ROBERT H; MACKLIN WENDY; WANG YANMING,期刊：Bioorganic & Medicinal Chemistry, 页码：8592-8599 , 文章类型： Article，,卷期：2010年18-24] C-11-Labeled N-methyl-4,4'-diaminostilbene ([C-11]MeDAS) was synthesized and evaluated as a novel radiotracer for in vivo microPET imaging of myelination. [C-11] MeDAS exhibits optimal lipophilicity for brain uptake with... The ODN probes conjugating the Cu(II) complex enhance the luminol chemiluminescence by assembling on the DNA template [作者：TANIGUCHI YOSUKE; NITTA AKIKO; PARK SUN MIN; KOHARA AKIKO; UZU TAKAHIRO; SASAKI SHIGEKI,期刊：Bioorganic & Medicinal Chemistry, 页码：8614-8617 , 文章类型： Article，,卷期：2010年18-24] Potent peroxidase-like activity of the beta-ketoenamine (1)-dicopper (II) complex (2) for the chemiluminescence (CL) of luminol either in the presence or absence of H2O2 has been previously demonstrated by our group. In ... Structure based optimization of chromen-based TNF-alpha converting enzyme (TACE) inhibitors on S1 ' pocket and their quantitative structure-activity relationship (QSAR) study [作者：YANG JEE SUN; CHUN KWANGWOO; PARK JUNG EUN; CHO MISUN; SEO JEONGJEA; SONG DOONA; YOON HONGCHUL; PARK CHUNHO; JOE BOYOUNG; CHOI JONGHEE; KIM MYUNGHWA; HAN GYOONHEE,期刊：Bioorganic & Medicinal Chemistry, 页码：8618-8629 , 文章类型： Article，,卷期：2010年18-24] A series of coumarin based TACE inhibitors were designed to bind in S1' pocket of TACE enzyme based on their docking study. Twelve analogues were synthesized and most of compounds were active in vitro TACE enzyme inhibit... Convergent synthesis of fluorescence-labeled probes of Annonaceous acetogenins and visualization of their cell distribution [作者：KOJIMA NAOTO; MORIOKA TAKEKUNI; URABE DAISUKE; YANO MASAHIRO; SUGA YUKI; MAEZAKI NAOYOSHI; OHASHIKOBAYASHI AYAKO; FUJIMOTO YASUYUKI; MAEDA MASATOMO; YAMORI TAKAO; YOSHIMITSU TAKEHIKO; TANAKA TETSUAKI,期刊：Bioorganic & Medicinal Chemistry, 页码：8630-8641 , 文章类型： Article，,卷期：2010年18-24] The convergent synthesis of fluorescence-labeled solamin, an antitumor Annonaceous acetogenin, was accomplished by two asymmetric alkynylations of 2,5-diformyl tetrahydrofuran with an alkyne tagged with fluorescent group... Design, synthesis, and characterization of BK channel openers based on oximation of abietane diterpene derivatives [作者：CUI YONGMEI; YASUTOMI ERIKO; OTANI YUKO; IDO KATSUTOSHI; YOSHINAGA TAKASHI; SAWADA KOHEI; OHWADA TOMOHIKO,期刊：Bioorganic & Medicinal Chemistry, 页码：8642-8659 , 文章类型： Article，,卷期：2010年18-24] Oxime ether derivatives at the benzylic position of unsubstituted, dichloro, trichloro, and monobromo derivatives of the aromatic C-ring of dehydroabietic acid and podocarpic acid were synthesized and evaluated as BK cha... Synthesis and biological evaluation of new camptothecin derivatives obtained by modification of position 20 [作者：RIVA ELENA; COMI DANIELA; BORRELLI STELLA; COLOMBO FRANCESCO; DANIELI BRUNO; BORLAK JURGEN; EVENSEN LASSE; LORENS JAMES B; FONTANA GABRIELE; GIA ORNELLA MARIA; VIA LISA DALLA; PASSARELLA DANIELE,期刊：Bioorganic & Medicinal Chemistry, 页码：8660-8668 , 文章类型： Article，,卷期：2010年18-24] The preparation and biological evaluation of a novel series of dimeric camptothecin derivatives are described. All the new compounds showed a significant ability to inhibit human tumor cell growth with IC50 values rangin... A protected L-bromophosphonomethylphenylalanine amino acid derivative (BrPmp) for synthesis of irreversible protein tyrosine phosphatase inhibitors [作者：TULSI NARESH S; DOWNEY A MICHAEL; CAIRO CHRISTOPHER W,期刊：Bioorganic & Medicinal Chemistry, 页码：8679-8686 , 文章类型： Article，,卷期：2010年18-24] Protein tyrosine phosphatases (PTPs) are important therapeutic targets for medicinal chemists and biochemists. General strategies for the development of inhibitors of these enzymes are needed. Several modular strategies ... Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors (vol 18, pg 6031, 2010) [作者：MUSSO LOANA; DALLAVALLE SABRINA; MERLINI LUCIO; BAVA ADRIANA; NASINI GIANLUCA; PENCO SERGIO; GIANNINI GIUSEPPE; GIOMMARELLI CHIARA; DE CESARE ANDREA; ZUCO VALENTINA; VESCI LOREDANA; PISANO CLAUDIO; CASTORINA MASSIMO; MILAZZO FERDINANDO; CERVONI MARIA LUISA; DAL PIAZ FABRIZIO; DE TOMMASI NUNZIATINA; ZUNINO FRANCO,期刊：Bioorganic & Medicinal Chemistry, 页码：8687-8687 , 文章类型： Correction，,卷期：2010年18-24] Angiotensin II receptor type 1 (AT(1)) selective nonpeptidic antagonists-A perspective [作者：NAIK PRASHANT; MURUMKAR PRASHANT; GIRIDHAR RAJANI; YADAV MANGE RAM,期刊：Bioorganic & Medicinal Chemistry, 页码：8418-8456 , 文章类型： Review，,卷期：2010年18-24] Hypertension is a major risk factor for human morbidity and mortality through its effects on target organs like heart, brain and kidneys. More intensive treatment for the effective control of blood pressure significantly... Discovery of 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate as a potential antiproliferative agent by inhibiting histone deacetylase [作者：FU JIE; YANG YING; ZHANG XUEWEI; MAO WENJUN; ZHANG ZHIMING; ZHU HAILIANG,期刊：Bioorganic & Medicinal Chemistry, 页码：8457-8462 , 文章类型： Article，,卷期：2010年18-24] Twenty-one benzotriazoles (3-16 and 18-24) were synthesized and half of them (5, 8-16, 20, and 21) were reported for the first time. Their antiproliferative activities against three human cancer cells were assayed. It re... Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands [作者：OSMAN NOHA A; MAHMOUD AMR H; ALLARA MARCO; NIESS RAIMUND; ABOUZID KHALED A; DI MARZO VINCENZO; ABADI ASHRAF H,期刊：Bioorganic & Medicinal Chemistry, 页码：8463-8477 , 文章类型： Article，,卷期：2010年18-24] In the present work, we report upon the design, synthesis and biological evaluation of new anandamide derivatives obtained by modifications of the fatty acyl chain and/or of the ethanolamide 'tail'. The compounds are of ... Design, synthesis, and biological evaluation of novel N-gamma-carboline arylsulfonamides as anticancer agents [作者：CHEN JING; LIU TAO; WU RUI; LOU JIANSHU; CAO JI; DONG XIAOWU; YANG BO; HE QIAOJUN; HU YONGZHOU,期刊：Bioorganic & Medicinal Chemistry, 页码：8478-8484 , 文章类型： Article，,卷期：2010年18-24] A series of novel N-gamma-carboline arylsulfonamide derivatives designed based on the common feature of colchicine binding site inhibitors were synthesized and evaluated for their antiproliferative activity in vitro agai...