- An expert opinion on safinamide in Parkinson's disease
[作者:Onofrj, M; Bonanni, L; Thomas, A,期刊:Expert opinion on investigational drugs, 页码:1115-1125 , 文章类型: Article,,卷期:2008年17-7]
Background: Dopamine replacement therapies (levodopa, dopamine receptor agonists, anticholinergics, monoamine oxidase B inhibitors, and catechol-O-methyltransferase inhibitors) remain the cornerstones of therapeutic i...
- Agents that block advanced glycation end product (AGE)-RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular complications
[作者:Yamagishi, SI; Nakamura, K; Matsui, T; Ueda, S; Fukami, K; Okuda, S,期刊:Expert opinion on investigational drugs, 页码:983-996 , 文章类型: Review,,卷期:2008年17-7]
Background: Diabetic vascular complications are leading causes of acquired blindness, end-stage renal failure, a variety of neuropathies, and accelerated atherosclerosis, which together could account for disabilities ...
- Targeting the c-MET signaling pathway for cancer therapy
[作者:Liu, XD; Yao, WQ; Newton, RC; Scherle, PA,期刊:Expert opinion on investigational drugs, 页码:997-1011 , 文章类型: Review,,卷期:2008年17-7]
Background: In many human cancers, c-MET is activated via receptor overexpression, amplification, mutation and/or a ligand-dependent autocrine/ paracrine loop. These biochemical and genetic abnormalities have been cor...
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