- Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription
[作者:Wang, WG; Lian, N; Li, LZ; Moss, HE; Wang, WX; Perrien, DS; Elefteriou, F; Yang, XL,期刊:Development, 页码:4143-4153 , 文章类型: Article,,卷期:2009年136-24]
- Activating transcription factor 4 (Atf4) is a leucine-zipper-containing protein of the cAMP response element-binding protein (CREB) family. Ablation of Atf4 (Atf4(-/-)) in mice leads to severe skeletal defects, including...
- Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis
[作者:Urbano, JM; Torgler, CN; Molnar, C; Tepass, U; Lopez-Varea, A; Brown, NH; de Celis, JF; Martin-Bermudo, MD,期刊:Development, 页码:4165-4176 , 文章类型: Article,,卷期:2009年136-24]
- Laminins are heterotrimeric molecules found in all basement membranes. In mammals, they have been involved in diverse developmental processes, from gastrulation to tissue maintenance. The Drosophila genome encodes two la...
- Sanpodo: a context-dependent activator and inhibitor of Notch signaling during asymmetric divisions
[作者:Babaoglan, AB; O'Connor-Giles, KM; Mistry, H; Schickedanz, A; Wilson, BA; Skeath, JB,期刊:Development, 页码:4089-4098 , 文章类型: Article,,卷期:2009年136-24]
- Asymmetric cell divisions generate sibling cells of distinct fates ('A', 'B') and constitute a fundamental mechanism that creates cell-type diversity in multicellular organisms. Antagonistic interactions between the Notc...
- Cdx2 regulation of posterior development through non-Hox targets
[作者:Savory, JGA; Bouchard, N; Pierre, V; Rijli, FM; De Repentigny, Y; Kothary, R; Lohnes, D,期刊:Development, 页码:4099-4110 , 文章类型: Article,,卷期:2009年136-24]
- The homeodomain transcription factors Cdx1, Cdx2 and Cdx4 play essential roles in anteroposterior vertebral patterning through regulation of Hox gene expression. Cdx2 is also expressed in the trophectoderm commencing at ...
- Neuropeptide Y functions as a facilitator of GDNF-induced budding of the Wolffian duct
[作者:Choi, Y; Tee, JB; Gallegos, TF; Shah, MM; Oishi, H; Sakurai, H; Kitamura, S; Wu, W; Bush, KT; Nigam, SK,期刊:Development, 页码:4213-4224 , 文章类型: Article,,卷期:2009年136-24]
- Ureteric bud (UB) emergence from the Wolffian duct (WD), the initiating step in metanephric kidney morphogenesis, is dependent on GDNF; however, GDNF by itself is generally insufficient to induce robust budding of the is...
- Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice
[作者:Han, J; Mayo, J; Xu, X; Li, JY; Bringas, P; Maas, RL; Rubenstein, JLR; Chai, Y,期刊:Development, 页码:4225-4233 , 文章类型: Article,,卷期:2009年136-24]
- Cleft palate represents one of the most common congenital birth defects in human. During embryonic development, palatal shelves display oronasal (O-N) and anteroposterior polarity before the onset of fusion, but how the ...
- Patched regulates Smoothened trafficking using lipoprotein-derived lipids
[作者:Khaliullina, H; Panakova, D; Eugster, C; Riedel, F; Carvalho, M; Eaton, S,期刊:Development, 页码:4111-4121 , 文章类型: Article,,卷期:2009年136-24]
- Hedgehog (Hh) is a lipoprotein-borne ligand that regulates both patterning and proliferation in a wide variety of vertebrate and invertebrate tissues. When Hh is absent, its receptor Patched (Ptc) represses Smoothened (S...
- The cadherin Fat2 is required for planar cell polarity in the Drosophila ovary
[作者:Viktorinova, I; Konig, T; Schlichting, K; Dahmann, C,期刊:Development, 页码:4123-4132 , 文章类型: Article,,卷期:2009年136-24]
- Planar cell polarity is an important characteristic of many epithelia. In the Drosophila wing, eye and abdomen, establishment of planar cell polarity requires the core planar cell polarity genes and two cadherins, Fat an...
- Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila
[作者:Chen, DS; Wang, Q; Huang, HD; Xia, LX; Jiang, XY; Kan, LJ; Sun, QM; Chen, DH,期刊:Development, 页码:4133-4142 , 文章类型: Article,,卷期:2009年136-24]
- Increasing evidence supports the idea that the regulation of stem cells requires both extrinsic and intrinsic mechanisms. However, much less is known about how intrinsic signals regulate the fate of stem cells. Studies o...
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