As the genetic combination of originally separate proteins, fusion proteins are successful biopharmaceuticals. This review summarizes the fusion proteins that are approved for use in the clinic and those that are current...
Ensuring the safety of therapeutic modalities produced and purified from biological systems is of high concern. Regulatory authorities and the biopharmaceutical industry are continuously seeking to improve methods for th...
Phytocannabinoids from the plant Cannabis sativa induce a variety of physiological and pharmacological responses in living systems, including anti-inflammatory, antinociceptive, anti-ulcer and antitumor activities. The d...
Since the early 1960s, small organic molecules derived naturally from microbes and plants have provided a number of useful cancer chemotherapeutic drugs. The search for naturally occurring lead compounds of this type has...
The discovery and structure elucidation of natural products has advanced through significant developments in spectroscopic techniques, particularly nuclear magnetic resonance (NMR). Improvements in microprobe, microcoil ...
Natural products continue to represent an excellent source for lead structures for drug discovery. However, new concepts are required to increase the probability of finding new bioactive structures. The post-genomic worl...
Myxobacteria produce an immense variety of natural products with useful biological activities. This review highlights recent advances to evaluate and further explore their biosynthetic potential for drug discovery, with ...
The peptides in the venoms of predatory marine snails belonging to the genus Conus ('cone snails') have well-established therapeutic applications for the treatment of pain and epilepsy. This review discusses the neuropro...
Cancer initiation and progression has been linked to oxidative stress, a condition in which the balance between production and disposal of reactive oxygen or nitrogen species is altered. Oxidative stress has several prot...
Targeted drugs inhibit specific pathways that contribute to the malignant phenotype of cancer cells. The initial success of molecularly targeted therapies raised hope that newly developed agents would evade the general m...
TGF beta is a pleiotropic cytokine that has regulatory roles during embryonic development and adult tissue homeostasis, and is especially important for epithelial, neural and immune system differentiation and function. A...
Epigenetic changes occurring during the development of organisms can be altered by the presence of synthetic substances in the environment, resulting in developmental reprogramming and disease. The occurrence of such cha...
In recent decades, mAbs have emerged as therapeutics. Nine mAbs have been approved for cancer therapy. However, the efficiency of mAbs is far from optimal, and antibody engineering is actively used to improve the molecul...