- Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma
[作者：Hu, YL; DeLay, M; Jahangiri, A; Molinaro, AM; Rose, SD; Carbonell, WS; Aghi, MK,期刊：Cancer research, 页码：1773-1783 , 文章类型： Article，,卷期：2012年72-7]
- Antiangiogenic therapy leads to devascularization that limits tumor growth. However, the benefits of angiogenesis inhibitors are typically transient and resistance often develops. In this study, we explored the hypothesi...
- Tumor Cell-Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis
[作者：Endo, M; Nakano, M; Kadomatsu, T; Fukuhara, S; Kuroda, H; Mikami, S; Hato, T; Aoi, J; Horiguchi, H; Miyata, K; Odagiri, H; Masuda, T; Harada, M; Horio, H; Hishima, T; Nomori, H; Ito, T; Yamamoto, Y; Minami, T; Okada, S; Takahashi, T; Mochizuki, N; Iwase, H; Oike, Y,期刊：Cancer research, 页码：1784-1794 , 文章类型： Article，,卷期：2012年72-7]
- Strategies to inhibit metastasis have been mainly unsuccessful in part due to insufficient mechanistic understanding. Here, we report evidence of critical role for the angiopoietin-like protein 2 (ANGPTL2) in metastatic ...
- 19p13.1 Is a Triple-Negative-Specific Breast Cancer Susceptibility Locus
[作者：Stevens, KN; Fredericksen, Z; Vachon, CM; Wang, XS; Margolin, S; Lindblom, A; Nevanlinna, H; Greco, D; Aittomaki, K; Blomqvist, C; Chang-Claude, J; Vrieling, A; Flesch-Janys, D; Sinn, HP; Wang-Gohrke, S; Nickels, S; Brauch, H; Ko, YD; Fischer, HP; Schmutzler, RK; Meindl, A; Bartram, CR; Schott, S; Engel, C; Godwin, AK; Weaver, J; Pathak, HB; Sharma, P; Brenner, H; Muller, H; Arndt, V; Stegmaier, C; Miron, P; Yannoukakos, D; Stavropoulou, A; Fountzilas, G; Gogas, HJ; Swann, R; Dwek, M; Perkins, A; Milne, RL; Benitez, J; Zamora, MP; Perez, JIA; Bojesen, SE; Nielsen, SF; Nordestgaard, BG; Flyger, H; Guenel, P; Truong, T; Menegaux, F; Cordina-Duverger, E; Burwinkel, B; Marme, F; Schneeweiss, A; Sohn, C; Sawyer, E; Tomlinson, I; Kerin, MJ; Peto, J; Johnson, N; Fletcher, O; Silva, ID; Fasching, PA; Beckmann, MW; Hartmann, A; Ekici, AB; Lophatananon, A; Muir, K; Puttawibul, P; Wiangnon, S; Schmidt, MK; Broeks, A; Braaf, LM; Rosenberg, EH; Hopper, JL; Apicella, C; Park, DJ; Southey, MC; Swerdl,期刊：Cancer research, 页码：1795-1803 , 文章类型： Article，,卷期：2012年72-7]
- The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with the risk of ovarian cancer. Here, we investigated 19p13.1 variation and risk of br...
- Enhanced Apoptosis and Tumor Growth Suppression Elicited by Combination of MEK (Selumetinib) and mTOR Kinase Inhibitors (AZD8055)
[作者：Holt, SV; Logie, A; Davies, BR; Alferez, D; Runswick, S; Fenton, S; Chresta, CM; Gu, Y; Zhang, JC; Wu, YL; Wilkinson, RW; Guichard, SM; Smith, PD,期刊：Cancer research, 页码：1804-1813 , 文章类型： Article，,卷期：2012年72-7]
- The mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase/AKT signaling pathways interact at multiple nodes in cancer, including at mTOR complexes, suggesting an increased likelihood of redundancy and inn...
- Paclitaxel Enhances Therapeutic Efficacy of the F8-IL2 Immunocytokine to EDA-Fibronectin-Positive Metastatic Human Melanoma Xenografts
[作者：Moschetta, M; Pretto, F; Berndt, A; Galler, K; Richter, P; Bassi, A; Oliva, P; Micotti, E; Valbusa, G; Schwager, K; Kaspar, M; Trachsel, E; Kosmehl, H; Bani, MR; Neri, D; Giavazzi, R,期刊：Cancer research, 页码：1814-1824 , 文章类型： Article，,卷期：2012年72-7]
- The selective delivery of bioactive agents to tumors reduces toxicity and enhances the efficacy of anticancer therapies. In this study, we show that the antibody F8, which recognizes perivascular and stromal EDA-fibronec...
- Retinoic Acid/Alpha-Interferon Combination Inhibits Growth and Promotes Apoptosis in Mantle Cell Lymphoma through Akt-Dependent Modulation of Critical Targets
[作者：Dal Col, J; Mastorci, K; Fae, DA; Muraro, E; Martorelli, D; Inghirami, G; Dolcetti, R,期刊：Cancer research, 页码：1825-1835 , 文章类型： Article，,卷期：2012年72-7]
- Mantle cell lymphoma (MCL) is characterized by a profound deregulation of the mechanisms controlling cell-cycle progression and survival. We herein show that the combination of 9-cis-retinoic acid (RA) and IFN-alpha indu...
- Rapamycin Resistance Is Linked to Defective Regulation of Skp2
[作者：Totary-Jain, H; Sanoudou, D; Dautriche, CN; Schneller, H; Zambrana, L; Marks, AR,期刊：Cancer research, 页码：1836-1843 , 文章类型： Article，,卷期：2012年72-7]
- The mammalian target of rapamycin (mTOR) plays a role in controlling malignant cellular growth. mTOR inhibitors, including rapamycin (sirolimus), are currently being evaluated in cancer trials. However, a significant num...
- A Universal Strategy for Adoptive Immunotherapy of Cancer through Use of a Novel T-cell Antigen Receptor
[作者：Urbanska, K; Lanitis, E; Poussin, M; Lynn, RC; Gavin, BP; Kelderman, S; Yu, J; Scholler, N; Powell, DJ,期刊：Cancer research, 页码：1844-1852 , 文章类型： Article，,卷期：2012年72-7]
- Adoptive immunotherapies composed of T cells engineered to express a chimeric antigen receptor (CAR) offer an attractive strategy for treatment of human cancer. However, CARs have a fixed antigen specificity such that on...
- Cancer Stem Cell Vaccination Confers Significant Antitumor Immunity
[作者：Ning, N; Pan, Q; Zheng, F; Teitz-Tennenbaum, S; Egenti, M; Yet, J; Li, M; Ginestier, C; Wicha, MS; Moyer, JS; Prince, MEP; Xu, YX; Zhang, XL; Huang, S; Chang, AE; Li, Q,期刊：Cancer research, 页码：1853-1864 , 文章类型： Article，,卷期：2012年72-7]
- Most studies of cancer stem cells (CSC) involve the inoculation of cells from human tumors into immunosuppressed mice, preventing an assessment on the immunologic interactions and effects of CSCs. In this study, we exami...
- miRNA Signatures Associate with Pathogenesis and Progression of Osteosarcoma
[作者：Jones, KB; Salah, Z; Del Mare, S; Galasso, M; Gaudio, E; Nuovo, GJ; Lovat, F; LeBlanc, K; Palatini, J; Randall, RL; Volinia, S; Stein, GS; Croce, CM; Lian, JB; Aqeilan, RI,期刊：Cancer research, 页码：1865-1877 , 文章类型： Article，,卷期：2012年72-7]
- Osteosarcoma remains a leading cause of cancer death in adolescents. Treatment paradigms and survival rates have not improved in two decades. Driving the lack of therapeutic inroads, the molecular etiology of osteosarcom...
- Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells
[作者：Mulholland, DJ; Kobayashi, N; Ruscetti, M; Zhi, A; Tran, LM; Huang, JT; Gleave, M; Wu, H,期刊：Cancer research, 页码：1878-1889 , 文章类型： Article，,卷期：2012年72-7]
- PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models, deletion of Pten alone fails to mimic the significant metastatic...
- Jab1/CSN5 Negatively Regulates p27 and Plays a Role in the Pathogenesis of Nasopharyngeal Carcinoma
[作者：Pan, YB; Zhang, QX; Tian, L; Wang, X; Fan, XH; Zhang, HH; Claret, FX; Yang, HL,期刊：Cancer research, 页码：1890-1900 , 文章类型： Article，,卷期：2012年72-7]
- Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus-associated malignancy most common in East Asia and Africa. Aberrant expression of Jab1/CSN5, a negative regulator of the cell-cycle inhibitor p27, is correlated wit...
- Lactate-Induced IL-8 Pathway in Endothelial Cells-Letter
[作者：Pinheiro, C; Longatto, A; Nogueira, R; Schmitt, F; Baltazar, F,期刊：Cancer research, 页码：1901-1902 , 文章类型： Letter，,卷期：2012年72-7]
- Vegran and colleagues proposed a model in which the lactate released from tumor cells through MCT4 would be taken up by endothelial cells via the MCT1 transporter and stimulate angiogenesis, using human umbilical vein en...
- Shedding Light on Melanocyte Pathobiology In Vivo
[作者：Zaidi, MR; De Fabo, EC; Noonan, FP; Merlino, G,期刊：Cancer research, 页码：1591-1595 , 文章类型： Review，,卷期：2012年72-7]
- Cutaneous malignant melanoma is rapidly increasing in the developed world and continues to be a challenge in the clinic. Although extensive epidemiologic evidence points to solar UV as the major risk factor for melanoma,...
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