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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共19条记录   JNK-Induced Apoptosis, Compensatory Growth, and Cancer Stem Cells [作者：Chen, F,期刊：Cancer research, 页码：379-386 , 文章类型： Review，,卷期：2012年72-2] Overwhelming evidence suggests that c-jun-NH(2)-kinases (JNK) are a set of key stress-responsive kinases that mediate cell apoptosis, which is an important process for tumor suppression. However, JNKs have also been impl... Metastasis-Associated Protein 1/Nucleosome Remodeling and Histone Deacetylase Complex in Cancer [作者：Li, DQ; Pakala, SB; Nair, SS; Eswaran, J; Kumar, R,期刊：Cancer research, 页码：387-394 , 文章类型： Review，,卷期：2012年72-2] Cancer cells frequently exhibit deregulation of coregulatory molecules to drive the process of growth and metastasis. One such group of ubiquitously expressed coregulators is the metastasis-associated protein (MTA) famil... Stress-Regulated Transcription Factor ATF4 Promotes Neoplastic Transformation by Suppressing Expression of the INK4a/ARF Cell Senescence Factors [作者：Horiguchi, M; Koyanagi, S; Okamoto, A; Suzuki, SO; Matsunaga, N; Ohdo, S,期刊：Cancer research, 页码：395-401 , 文章类型： Article，,卷期：2012年72-2] Many cancers overexpress ATF4, a stress-induced transcription factor that promotes cell survival under hypoxic conditions and other stresses of the tumor microenvironment, but the potential contributions of ATF4 to oncog... Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion [作者：Sorensen, AG; Emblem, KE; Polaskova, P; Jennings, D; Kim, H; Ancukiewicz, M; Wang, MY; Wen, PY; Ivy, P; Batchelor, TT; Jain, RK,期刊：Cancer research, 页码：402-407 , 文章类型： Article，,卷期：2012年72-2] The abnormal vasculature of the tumor microenvironment supports progression and resistance to treatment. Judicious application of antiangiogenic therapy may normalize the structure and function of the tumor vasculature, ... Genetic Variants in Oxidative Stress-Related Genes Predict Chemoresistance in Primary Breast Cancer: A Prospective Observational Study and Validation [作者：Yu, KD; Huang, AJ; Fan, L; Li, WF; Shao, ZM,期刊：Cancer research, 页码：408-419 , 文章类型： Article，,卷期：2012年72-2] Chemotherapy response in patients with primary breast cancer is difficult to predict and the role of host genetic factors has not been thoroughly investigated. We hypothesized that polymorphisms in oxidative stress (OS)r... Interleukin-10 Ablation Promotes Tumor Development, Growth, and Metastasis [作者：Tanikawa, T; Wilke, CM; Kryczek, I; Chen, GY; Kao, J; Nunez, G; Zou, WP,期刊：Cancer research, 页码：420-429 , 文章类型： Article，,卷期：2012年72-2] Interleukin-10 (IL-10) is a broadly acting immune inhibitory cytokine that is generally thought to support tumor growth. Here we challenge this view with evidence that genetic ablation of IL-10 in the mouse significantly... Potent Induction of Tumor Immunity by Combining Tumor Cryoablation with Anti-CTLA-4 Therapy [作者：Waitz, R; Solomon, SB; Petre, EN; Trumble, AE; Fasso, M; Norton, L; Allison, JP,期刊：Cancer research, 页码：430-439 , 文章类型： Article，,卷期：2012年72-2] Thermal ablation to destroy tumor tissue may help activate tumor-specific T cells by elevating the presentation of tumor antigens to the immune system. However, the antitumor activity of these T cells may be restrained b... Platelet-Derived MHC Class I Confers a Pseudonormal Phenotype to Cancer Cells That Subverts the Antitumor Reactivity of Natural Killer Immune Cells [作者：Placke, T; Orgel, M; Schaller, M; Jung, G; Rammensee, HG; Kopp, HG; Salih, HR,期刊：Cancer research, 页码：440-448 , 文章类型： Article，,卷期：2012年72-2] Natural killer (NK) cells are cytotoxic lymphocytes that play an important role in tumor immunosurveillance, preferentially eliminating targets with low or absent expression of MHC class I and stress-induced expression o... Chromogranin A Regulates Tumor Self-Seeding and Dissemination [作者：Dondossola, E; Crippa, L; Colombo, B; Ferrero, E; Corti, A,期刊：Cancer research, 页码：449-459 , 文章类型： Article，,卷期：2012年72-2] Cancer progression involves the seeding of malignant cells in circulation and the colonization of distant organs. However, circulating neoplastic cells can also reinfiltrate the tumor of origin. This process, called "tum... Tumor Suppressive MicroRNAs miR-34a/c Control Cancer Cell Expression of ULBP2, a Stress-Induced Ligand of the Natural Killer Cell Receptor NKG2D [作者：Heinemann, A; Zhao, F; Pechlivanis, S; Eberle, J; Steinle, A; Diederichs, S; Schadendorf, D; Paschen, A,期刊：Cancer research, 页码：460-471 , 文章类型： Article，,卷期：2012年72-2] Malignant cells express ligands for the natural killer cell immunoreceptor NKG2D, which sensitizes to early recognition and elimination by cytotoxic lymphocytes and provides an innate barrier against tumor development. H... Role of JNK in Mammary Gland Development and Breast Cancer [作者：Cellurale, C; Girnius, N; Jiang, F; Cavanagh-Kyros, J; Lu, SL; Garlick, DS; Mercurio, AM; Davis, RJ,期刊：Cancer research, 页码：472-481 , 文章类型： Article，,卷期：2012年72-2] cJun NH(2)-terminal kinase (JNK) signaling has been implicated in the developmental morphogenesis of epithelial organs. In this study, we employed a compound deletion of the murine Jnk1 and Jnk2 genes in the mammary glan... Arsenic Trioxide Treatment Decreases the Oxygen Consumption Rate of Tumor Cells and Radiosensitizes Solid Tumors [作者：Diepart, C; Karroum, O; Magat, J; Feron, O; Verrax, J; Calderon, PB; Gregoire, V; Leveque, P; Stockis, J; Dauguet, N; Jordan, BF; Gallez, B,期刊：Cancer research, 页码：482-490 , 文章类型： Article，,卷期：2012年72-2] Arsenic trioxide (As(2)O(3)) is an effective therapeutic against acute promyelocytic leukemia and certain solid tumors. Because As(2)O(3) inhibits mitochondrial respiration in leukemia cells, we hypothesized that As(2)O(... Functional Interaction between Responses to Lactic Acidosis and Hypoxia Regulates Genomic Transcriptional Outputs [作者：Tang, XH; Lucas, JE; Chen, JLY; LaMonte, G; Wu, JL; Wang, MC; Koumenis, C; Chi, JT,期刊：Cancer research, 页码：491-502 , 文章类型： Article，,卷期：2012年72-2] Within solid tumor microenvironments, lactic acidosis, and hypoxia each have powerful effects on cancer pathophysiology. However, the influence that these processes exert on each other is unknown. Here, we report that a ... Circulating Insulin-Like Growth Factors and IGF-Binding Proteins in PSA-Detected Prostate Cancer: The Large Case-Control Study ProtecT [作者：Rowlands, MA; Holly, JMP; Gunnell, D; Donovan, J; Lane, JA; Hamdy, F; Neal, DE; Oliver, S; Smith, GD; Martin, RM,期刊：Cancer research, 页码：503-515 , 文章类型： Article，,卷期：2012年72-2] Circulating insulin-like growth factor-I (IGF-I) has been studied extensively in prostate cancer, but there is still little information about IGFs and IGF-binding proteins (IGFBP) in cancers detected by the prostate-spec... Regulation of Matrix Metalloproteinase Genes by E2F Transcription Factors: Rb-Raf-1 Interaction as a Novel Target for Metastatic Disease [作者：Johnson, JL; Pillai, S; Pernazza, D; Sebti, SM; Lawrence, NJ; Chellappan, SP,期刊：Cancer research, 页码：516-526 , 文章类型： Article，,卷期：2012年72-2] The retinoblastoma (Rb)-E2F transcriptional regulatory pathway plays a major role in cell-cycle regulation, but its role in invasion and metastasis is less well understood. We find that many genes involved in the invasio... Androgen Deprivation Causes Epithelial-Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy [作者：Sun, YT; Wang, BE; Leong, KG; Yue, P; Li, L; Jhunjhunwala, S; Chen, D; Seo, K; Modrusan, Z; Gao, WQ; Settleman, J; Johnson, L,期刊：Cancer research, 页码：527-536 , 文章类型： Article，,卷期：2012年72-2] Androgen deprivation is currently a standard-of-care, first-line therapy for prostate cancer in the United States. Although this regimen effectively regresses androgen-dependent disease, relapse often occurs in an androg...