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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共31条记录   Rheumatoid arthritis and multiple sclerosis: Direful siblings, different strategies [作者：Schett, G,期刊：FEBS Letters, 页码：3601-3602 , 文章类型： Editorial Material，,卷期：2011年585-23] Regulatory T-cells in systemic lupus erythematosus and rheumatoid arthritis [作者：Chavele, KM; Ehrenstein, MR,期刊：FEBS Letters, 页码：3603-3610 , 文章类型： Review，,卷期：2011年585-23] Regulatory T-cells (Tregs) are the guardians of peripheral tolerance acting to prevent autoimmune diseases such as systemic lupus erythomatosus (SLE) and rheumatoid arthritis ( RA). Defects in Tregs have been reported in... Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity [作者：Chen, X; Oppenheim, JJ,期刊：FEBS Letters, 页码：3611-3618 , 文章类型： Review，,卷期：2011年585-23] Anti-TNF treatment is effective in a majority of rheumatoid arthritis (RA), however, this treatment can unexpectedly trigger the onset or exacerbate multiple sclerosis (MS). Recent progress in cellular immunology researc... New insights into the functional role of the rheumatoid arthritis shared epitope [作者：de Almeida, DE; Ling, S; Holoshitz, J,期刊：FEBS Letters, 页码：3619-3626 , 文章类型： Review，,卷期：2011年585-23] The shared epitope (SE) - an HLA-DRB1-encoded 5-amino acid sequence motif carried by the vast majority of rheumatoid arthritis (RA) patients - is a risk factor for severe disease. The mechanistic basis of RA-SE associati... Insight from genome-wide association studies in rheumatoid arthritis and multiple sclerosis [作者：Suzuki, A; Kochi, Y; Okada, Y; Yamamoto, K,期刊：FEBS Letters, 页码：3627-3632 , 文章类型： Review，,卷期：2011年585-23] Autoimmune diseases are caused by multiple genes and environmental effects. In addition, genetic contributions and the number of associated genes differ among different diseases and ethnic populations. Genome-wide associ... Thymus, innate immunity and autoimmune arthritis: Interplay of gene and environment [作者：Sakaguchi, S; Tanaka, S; Tanaka, A; Ito, Y; Maeda, S; Sakaguchi, N; Hashimoto, M,期刊：FEBS Letters, 页码：3633-3639 , 文章类型： Review，,卷期：2011年585-23] A hypomorphic mutation of the gene encoding zeta-associated protein-70 (ZAP-70), a signaling molecule in T cells, produces autoimmune arthritis in mice under a microbially conventional condition but not in a clean enviro... Arthritis in space and time - To boldly go! [作者：Benson, RA; Patakas, A; McQueenie, R; Ross, K; McInnes, IB; Brewer, JM; Garside, P,期刊：FEBS Letters, 页码：3640-3648 , 文章类型： Review，,卷期：2011年585-23] Despite the profound impact of biologics on the treatment of rheumatoid arthritis (RA), long lasting disease remission remains elusive. We propose that this is a consequence of failing to target the right molecular pathw... Promoting myelin repair and return of function in multiple sclerosis [作者：Zhang, JY; Kramer, EG; Asp, L; Dutta, DJ; Navrazhina, K; Pham, T; Mariani, JN; Argaw, AT; Melendez-Vasquez, CV; John, GR,期刊：FEBS Letters, 页码：3813-3820 , 文章类型： Review，,卷期：2011年585-23] Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Conduction block in demyelinated axons underlies early neurological symptoms, but axonal transection and neuronal loss are believed to be respo... Regulation of remyelination in multiple sclerosis [作者：Hanafy, KA; Sloane, JA,期刊：FEBS Letters, 页码：3821-3828 , 文章类型： Review，,卷期：2011年585-23] Multiple sclerosis is a common demyelinating disease that worsens over the course of disease, a significant problem in clinical management. Disability in MS is significantly promoted by poor repair and remyelination of l... The role of immune semaphorins in multiple sclerosis [作者：Okuno, T; Nakatsuji, Y; Kumanogoh, A,期刊：FEBS Letters, 页码：3829-3835 , 文章类型： Review，,卷期：2011年585-23] The nervous and immune systems have similar functional characteristics. Both have an intricate network of synaptic connections and an exquisite communication system that enable intercellular signal transduction. Although... Ion channels in autoimmune neurodegeneration [作者：Ehling, P; Bittner, S; Budde, T; Wiendl, H; Meuth, SG,期刊：FEBS Letters, 页码：3836-3842 , 文章类型： Review，,卷期：2011年585-23] Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances ... Effector T cells in rheumatoid arthritis: Lessons from animal models [作者：Alzabin, S; Williams, RO,期刊：FEBS Letters, 页码：3649-3659 , 文章类型： Review，,卷期：2011年585-23] The development of an immune response to self antigens drives naive T cells to differentiate into subsets of CD8(+) and CD4(+) effector cells including T(H)1, T(H)2, cells and the more recently described T(H)17, and regu... Toll-like receptors in rheumatic diseases: Are we paying a high price for our defense against bugs? [作者：Santegoets, KCM; van Bon, L; van den Berg, WB; Wenink, MH; Radstake, TRDJ,期刊：FEBS Letters, 页码：3660-3666 , 文章类型： Review，,卷期：2011年585-23] In the last decade Toll-like receptor (TLR) research has led to new insights in the pathogenesis of many rheumatic diseases. In autoimmune diseases like systemic lupus erythematosus, rheumatoid arthritis and systemic scl... MicroRNAs in rheumatoid arthritis [作者：Ceribelli, A; Nahid, MA; Satoh, M; Chan, EKL,期刊：FEBS Letters, 页码：3667-3674 , 文章类型： Review，,卷期：2011年585-23] Rheumatoid arthritis (RA) is a chronic and severe autoimmune disease that affects joint tissues, bone, and cartilage. However, the pathogenesis of RA is still unclear. Autoantibodies such as rheumatoid factor and anti-cy... Progranulin: A promising therapeutic target for rheumatoid arthritis [作者：Liu, CJ,期刊：FEBS Letters, 页码：3675-3680 , 文章类型： Review，,卷期：2011年585-23] Progranulin (PGRN) is an autocrine growth factor with multiple functions. This review provides updates about the interplays of PGRN with extracellular matrix proteins, proteolytic enzymes, inflammatory cytokines, and cel... Citrullination of autoantigens: Upstream of TNF alpha in the pathogenesis of rheumatoid arthritis [作者：Quirke, AM; Fisher, BAC; Kinloch, AJ; Venables, PJ,期刊：FEBS Letters, 页码：3681-3688 , 文章类型： Review，,卷期：2011年585-23] Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by synovial inflammation and destruction of joints. Over 20 years ago, tumour necrosis factor alpha (TNF alpha) was identified as a key player in a ...