- Cellular DBP and E4BP4 proteins are critical for determining the period length of the circadian oscillator
[作者:Yamajuku, D; Shibata, Y; Kitazawa, M; Katakura, T; Urata, H; Kojima, T; Takayasu, S; Nakata, O; Hashimoto, S,期刊:FEBS Letters, 页码:2217-2222 , 文章类型: Article,,卷期:2011年585-14]
- The phenotypes of mice carrying clock gene mutations have been critical to understanding the mammalian clock function. However, behavior does not necessarily reflect cell-autonomous clock phenotypes, because of the hiera...
- Identification of a novel DNA element that promotes cell-to-cell transformation in Escherichia coli
[作者:Sobue, R; Kurono, N; Etchuya, R; Maeda, S,期刊:FEBS Letters, 页码:2223-2228 , 文章类型: Article,,卷期:2011年585-14]
- Recently, we discovered a novel phenomenon, "cell-to-cell transformation" by which non-conjugative plasmids are transmitted horizontally in co-cultures of Escherichia coli F- strains. In this study, we aimed to identify ...
- Inhibitory mechanism of pure curcumin on Wilms' tumor 1 (WT1) gene expression through the PKC alpha signaling pathway in leukemic K562 cells
[作者:Semsri, S; Krig, SR; Kotelawala, L; Sweeney, CA; Anuchapreeda, S,期刊:FEBS Letters, 页码:2235-2242 , 文章类型: Article,,卷期:2011年585-14]
- The aim of this study was to investigate the inhibitory mechanism of pure curcumin on WT1 expression in leukemic K562 cells. Pure curcumin suppressed WT1 expression, independent of effects on protein degradation or WT1 m...
- Inhibition of NF-kappa B by MG132 through ER stress-mediated induction of LAP and LIP
[作者:Nakajima, S; Kato, H; Takahashi, S; Johno, H; Kitamura, M,期刊:FEBS Letters, 页码:2249-2254 , 文章类型: Article,,卷期:2011年585-14]
- Proteasome inhibitor MG132 blocks activation of NF-kappa B by preventing degradation of I kappa B. In this report, we propose an alternative mechanism by which MG132 inhibits cytokine-triggered NF-kappa B activation. We ...
- Opposite effects of P2X7 and P2Y(2) nucleotide receptors on alpha-secretase-dependent APP processing in Neuro-2a cells
[作者:Leon-Otegui, M; Gomez-Villafuertes, R; Diaz-Hernandez, JI; Diaz-Hernandez, M; Miras-Portugal, MT; Gualix, J,期刊:FEBS Letters, 页码:2255-2262 , 文章类型: Article,,卷期:2011年585-14]
- The amyloid precursor protein (APP) is proteolytically processed by beta- and gamma-secretases to release amyloid-beta peptide (Ab), the main component found in senile plaques of Alzheimer's disease (AD) patient brains. ...
- Mitochondrial density contributes to the immune response of macrophages to lipopolysaccharide via the MAPK pathway
[作者:Kasahara, E; Sekiyama, A; Hori, M; Hara, K; Takahashi, N; Konishi, M; Sato, EF; Matsumoto, S; Okamura, H; Inoue, M,期刊:FEBS Letters, 页码:2263-2268 , 文章类型: Article,,卷期:2011年585-14]
- We investigated the role of mitochondrial reactive oxygen species (ROS) in the response of macrophages to lipopolysaccharide (LPS) using RAW 264.7 cells and their rho(0) cells lacking mitochondria. Mitochondrial density,...
- TRADD is critical for resistance to TRAIL-induced cell death through NF-kappa B activation
[作者:Kim, JY; Lee, JY; Kim, DG; Koo, GB; Yu, JW; Kim, YS,期刊:FEBS Letters, 页码:2144-2150 , 文章类型: Article,,卷期:2011年585-14]
- One major obstacle in the clinical application of TRAIL as a cancer therapeutic agent is the acquisition of TRAIL resistance. We found that deficiency of TRADD sensitizes cells to TRAIL-induced apoptosis. Enhanced cell d...
- LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: Impairment of the kinase activity by Parkinson's disease-associated mutations
[作者:Ohta, E; Kawakami, F; Kubo, M; Obata, F,期刊:FEBS Letters, 页码:2165-2170 , 文章类型: Article,,卷期:2011年585-14]
- LRRK2 is the causal molecule for autosomal-dominant familial Parkinson's disease, although its true function, including its physiological substrates, remains unknown. Here, using in vitro kinase assay with recombinant pr...
- p125/Sec23-interacting protein (Sec23ip) is required for spermiogenesis
[作者:Arimitsu, N; Kogure, T; Baba, T; Nakao, K; Hamamoto, H; Sekimizu, K; Yamamoto, A; Nakanishi, H; Taguchi, R; Tagaya, M; Tani, K,期刊:FEBS Letters, 页码:2171-2176 , 文章类型: Article,,卷期:2011年585-14]
- p125/Sec23ip is a phospholipase A(1)-like protein that interacts with Sec23, a coat component of COPII vesicles that bud from endoplasmic reticulum exit sites. To understand its physiological function, we produced p125 k...
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