- The autophagic paradox in cancer therapy
[作者：Wu, WKK; Coffelt, SB; Cho, CH; Wang, XJ; Lee, CW; Chan, FKL; Yu, J; Sung, JJY,期刊：Oncogene, 页码：939-953 , 文章类型： Review，,卷期：2012年31-8]
- Autophagy, hallmarked by the formation of double-membrane bound organelles known as autophagosomes, is a lysosome-dependent pathway for protein degradation. The role of autophagy in carcinogenesis is context dependent. A...
- Dominant-negative mechanism of leukemogenic PAX5 fusions
[作者：Kawamata, N; Pennella, MA; Woo, JL; Berk, AJ; Koeffler, HP,期刊：Oncogene, 页码：966-977 , 文章类型： Article，,卷期：2012年31-8]
- PAX5 encodes a master regulator of B-cell development. It fuses to other genes associated with acute lymphoblastoid leukemia (ALL). These fusion products are potent dominant-negative (DN) inhibitors of wild-type PAX5, re...
- Diagnostic and prognostic signatures from the small non-coding RNA transcriptome in prostate cancer
[作者：Martens-Uzunova, ES; Jalava, SE; Dits, NF; van Leenders, GJLH; Moller, S; Trapman, J; Bangma, CH; Litman, T; Visakorpi, T; Jenster, G,期刊：Oncogene, 页码：978-991 , 文章类型： Article，,卷期：2012年31-8]
- Prostate cancer (PCa) is the most frequent male malignancy and the second most common cause of cancer-related death in Western countries. Current clinical and pathological methods are limited in the prediction of postope...
- Upregulation of CD26 expression in epithelial cells and stromal cells during wound-induced skin tumour formation
[作者：Arwert, EN; Mentink, RA; Driskell, RR; Hoste, E; Goldie, SJ; Quist, S; Watt, FM,期刊：Oncogene, 页码：992-1000 , 文章类型： Article，,卷期：2012年31-8]
- We have previously described InvEE transgenic mice in which non-dividing, differentiating epidermal cells express oncogenically activated MAPK kinase 1 (MEK1). Skin wounding triggers tumour formation in InvEE mice via a ...
- A Rac1/PAK1 cascade controls beta-catenin activation in colon cancer cells
[作者：Zhu, G; Wang, Y; Huang, B; Liang, J; Ding, Y; Xu, A; Wu, W,期刊：Oncogene, 页码：1001-1012 , 文章类型： Article，,卷期：2012年31-8]
- P21-activated kinase 1 (PAK1) is associated with colon cancer progression and metastasis, whereas the molecular mechanism remains elusive. Here, we show that down-regulation of PAK1 in colon cancer cells reduces total be...
- Peroxisome proliferator-activated receptor delta confers resistance to peroxisome proliferator-activated receptor gamma-induced apoptosis in colorectal cancer cells
[作者：Wang, D; Ning, W; Xie, D; Guo, L; DuBois, RN,期刊：Oncogene, 页码：1013-1023 , 文章类型： Article，,卷期：2012年31-8]
- Peroxisome proliferator-activated receptor gamma (PPAR gamma) may serve as a useful target for drug development in nondiabetic diseases. However, some colorectal cancer cells are resistant to PPAR gamma agonists by mecha...
- Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs
[作者：Ma, W; Lin, Y; Xuan, W; Iversen, PL; Smith, LJ; Benchimol, S,期刊：Oncogene, 页码：1024-1033 , 文章类型： Article，,卷期：2012年31-8]
- The p53 tumor suppressor gene encodes a transcription factor that is commonly mutated in cancer. Tumors arise when premalignant cells are unable to undergo p53-dependent apoptosis, cell cycle arrest or DNA repair. The p5...
- Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer
[作者：Kim, K; Chadalapaka, G; Lee, SO; Yamada, D; Sastre-Garau, X; Defossez, PA; Park, YY; Lee, JS; Safe, S,期刊：Oncogene, 页码：1034-1044 , 文章类型： Article，,卷期：2012年31-8]
- The human POK family members are transcription factors with a POZ domain and zinc-fingers that act primarily as transcriptional repressors. Several members of this family are involved in oncogenesis and this prompted us ...
- FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells
[作者：McInnes, N; Sadlon, TJ; Brown, CY; Pederson, S; Beyer, M; Schultze, JL; McColl, S; Goodall, GJ; Barry, SC,期刊：Oncogene, 页码：1045-1054 , 文章类型： Article，,卷期：2012年31-8]
- The transcription factor FOXP3 has been identified as a tumour suppressor in the breast and prostate epithelia, but little is known about its specific mechanism of action. We have identified a feed-forward regulatory loo...
- NAC1 modulates sensitivity of ovarian cancer cells to cisplatin by altering the HMGB1-mediated autophagic response
[作者：Zhang, Y; Cheng, Y; Ren, X; Zhang, L; Yap, KL; Wu, H; Patel, R; Liu, D; Qin, ZH; Shih, IM; Yang, JM,期刊：Oncogene, 页码：1055-1064 , 文章类型： Article，,卷期：2012年31-8]
- Nucleus accumbens-1 (NAC1), a nuclear factor belonging to the BTB/POZ gene family, is known to have important roles in proliferation and growth of tumor cells and in chemotherapy resistance. Yet, the mechanisms underlyin...
- Epigenetic regulation of HIF-1 alpha in renal cancer cells involves HIF-1 alpha/2 alpha binding to a reverse hypoxia-response element
[作者：Xu, J; Wang, B; Xu, Y; Sun, L; Tian, W; Shukla, D; Barod, R; Grillari, J; Grillari-Voglauer, R; Maxwell, PH; Esteban, MA,期刊：Oncogene, 页码：1065-1072 , 文章类型： Article，,卷期：2012年31-8]
- Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene underlies the majority of sporadic clear cell renal cell carcinomas (CCRCCs) and is also responsible for the hereditary VHL cancer syndrome. VHL loss of f...
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