- P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance
[作者：de la Cruz-Morcillo, MA; Valero, MLL; Callejas-Valera, JL; Arias-Gonzalez, L; Melgar-Rojas, P; Galan-Moya, EM; Garcia-Gil, E; Garcia-Cano, J; Sanchez-Prieto, R,期刊：Oncogene, 页码：1073-1085 , 文章类型： Article，,卷期：2012年31-9]
- 5-Fluorouracil (5-FU), together with other drugs such as oxaliplatin, is one of the most important pharmacological agents in the treatment of colorectal cancer. Although mitogen-activated protein kinases (MAPKs) have bee...
- Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage
[作者：Xu, N; Libertini, S; Black, EJ; Lao, Y; Hegarat, N; Walker, M; Gillespie, DA,期刊：Oncogene, 页码：1086-1094 , 文章类型： Article，,卷期：2012年31-9]
- Here, we show that activation of the checkpoint effector kinase Chk1 in response to irradiation-induced DNA damage is minimal in G1, maximal during S-phase and diminishes as cells enter G2. In addition, formation of irra...
- Secondary peripheral chondrosarcoma evolving from osteochondroma as a result of outgrowth of cells with functional EXT
[作者：de Andrea, CE; Reijnders, CMA; Kroon, HM; de Jong, D; Hogendoorn, PCW; Szuhai, K; Bovee, JVMG,期刊：Oncogene, 页码：1095-1104 , 文章类型： Article，,卷期：2012年31-9]
- Secondary peripheral chondrosarcoma is the result of malignant transformation of a pre-existing osteochondroma, the most common benign bone tumor. Osteochondromas are caused by genetic abnormalities in EXT1 or EXT2: homo...
- Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma
[作者：de Lange, J; Ly, LV; Lodder, K; Verlaan-de Vries, M; Teunisse, AFAS; Jager, MJ; Jochemsen, AG,期刊：Oncogene, 页码：1105-1116 , 文章类型： Article，,卷期：2012年31-9]
- The prognosis of patients with uveal melanoma is poor. Because of the limited efficacy of current treatments, new therapeutic strategies need to be developed. Because p53 mutations are uncommon in uveal melanoma, reactiv...
- ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence
[作者：Weyemi, U; Lagente-Chevallier, O; Boufraqech, M; Prenois, F; Courtin, F; Caillou, B; Talbot, M; Dardalhon, M; Al Ghuzlan, A; Bidart, JM; Schlumberger, M; Dupuy, C,期刊：Oncogene, 页码：1117-1129 , 文章类型： Article，,卷期：2012年31-9]
- Activated Ras oncogene induces DNA-damage response by triggering reactive oxygen species (ROS) production and this is critical for oncogene-induced senescence. Until now, little connections between oncogene expression, R...
- Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate
[作者：Orr, B; Riddick, ACP; Stewart, GD; Anderson, RA; Franco, OE; Hayward, SW; Thomson, AA,期刊：Oncogene, 页码：1130-1142 , 文章类型： Article，,卷期：2012年31-9]
- The stromal microenvironment has key roles in prostate development and cancer, and cancer-associated fibroblasts (CAFs) stimulate tumourigenesis via several mechanisms including the expression of pro-tumourigenic factors...
- Phosphorylation of RelA/p65 promotes DNMT-1 recruitment to chromatin and represses transcription of the tumor metastasis suppressor gene BRMS1
[作者：Liu, Y; Mayo, MW; Nagji, AS; Smith, PW; Ramsey, CS; Li, D; Jones, DR,期刊：Oncogene, 页码：1143-1154 , 文章类型： Article，,卷期：2012年31-9]
- The majority of patients with lung cancer present with metastatic disease. Chronic inflammation and subsequent activation of nuclear factor-kappa B (NF-kappa B) have been associated with the development of cancers. The R...
- Absence of Wip1 partially rescues Atm deficiency phenotypes in mice
[作者：Darlington, Y; Nguyen, TA; Moon, SH; Herron, A; Rao, P; Zhu, C; Lu, X; Donehower, LA,期刊：Oncogene, 页码：1155-1165 , 文章类型： Article，,卷期：2012年31-9]
- Wild-type p53-induced phosphatase 1 (WIP1) is a serine/threonine phosphatase that dephosphorylates proteins in the ataxia telangiectasia mutated (ATM)-initiated DNA damage response pathway. WIP1 may have a homeostatic ro...
- Defining a role for sphingosine kinase 1 in p53-dependent tumors
[作者：Heffernan-Stroud, LA; Helke, KL; Jenkins, RW; De Costa, AM; Hannun, YA; Obeid, LM,期刊：Oncogene, 页码：1166-1175 , 文章类型： Article，,卷期：2012年31-9]
- p53 is a crucial tumor suppressor that is mutated or deleted in a majority of cancers. Exactly how p53 prevents tumor progression has proved elusive for many years; however, this information is crucial to define targets ...
- Hipk2 cooperates with p53 to suppress gamma-ray radiation-induced mouse thymic lymphoma
[作者：Mao, JH; Wu, D; Kim, IJ; Kang, HC; Wei, G; Climent, J; Kumar, A; Pelorosso, FG; DelRosario, R; Huang, EJ; Balmain, A,期刊：Oncogene, 页码：1176-1180 , 文章类型： Article，,卷期：2012年31-9]
- A genome-wide screen for genetic alterations in radiation-induced thymic lymphomas generated from p53+/- and p53-/- mice showed frequent loss of heterozygosity (LOH) on chromosome 6. Fine mapping of these LOH regions rev...
- Human homolog of Drosophila expanded, hEx, functions as a putative tumor suppressor in human cancer cell lines independently of the Hippo pathway
[作者：Visser-Grieve, S; Hao, Y; Yang, X,期刊：Oncogene, 页码：1189-1195 , 文章类型： Article，,卷期：2012年31-9]
- The Hippo signaling network is proving to be an essential regulator within the cell, participating in multiple cellular phenotypes including cell proliferation, apoptosis, cell migration and organ size control. Much of t...
- A refined molecular taxonomy of breast cancer
[作者：Guedj, M; Marisa, L; de Reynies, A; Orsetti, B; Schiappa, R; Bibeau, F; MacGrogan, G; Lerebours, F; Finetti, P; Longy, M; Bertheau, P; Bertrand, F; Bonnet, F; Martin, AL; Feugeas, JP; Bieche, I; Lehmann-Che, J; Lidereau, R; Birnbaum, D; Bertucci, F; de The, H; Theillet, C,期刊：Oncogene, 页码：1196-1206 , 文章类型： Article，,卷期：2012年31-9]
- The current histoclinical breast cancer classification is simple but imprecise. Several molecular classifications of breast cancers based on expression profiling have been proposed as alternatives. However, their reliabi...
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