- Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma
[作者：Eppinga, RD; Krueger, EW; Weller, SG; Zhang, L; Cao, H; McNiven, MA,期刊：Oncogene, 页码：1228-1241 , 文章类型： Article，,卷期：2012年31-10]
- Pancreatic ductal tumors invade local parenchyma and metastasize to distant organs. Src-mediated tyrosine kinase signaling pathways promote pancreatic ductal adenocarcinoma (PDAC) metastasis, though the molecular mechani...
- Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers
[作者：Lee, J; Li, L; Gretz, N; Gebert, J; Dihlmann, S,期刊：Oncogene, 页码：1242-1253 , 文章类型： Article，,卷期：2012年31-10]
- Absent in Melanoma 2 (AIM2) is a member of the HIN-200 family of hematopoietic, IFN-inducible, nuclear proteins, associated with both, infection defense and tumor pathology. Recently, AIM2 was found to act as a DNA senso...
- Overexpression of ribosomal RNA in prostate cancer is common but not linked to rDNA promoter hypomethylation
[作者：Uemura, M; Zheng, Q; Koh, CM; Nelson, WG; Yegnasubramanian, S; De Marzo, AM,期刊：Oncogene, 页码：1254-1263 , 文章类型： Article，,卷期：2012年31-10]
- Alterations in nucleoli, including increased numbers, increased size, altered architecture and increased function are hallmarks of prostate cancer cells. The mechanisms that result in increased nucleolar size, number and...
- Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death
[作者：Ratushny, V; Pathak, HB; Beeharry, N; Tikhmyanova, N; Xiao, F; Li, T; Litwin, S; Connolly, DC; Yen, TJ; Weiner, LM; Godwin, AK; Golemis, EA,期刊：Oncogene, 页码：1217-1227 , 文章类型： Article，,卷期：2012年31-10]
- Increased activity of SRC family kinases promotes tumor invasion and metastasis, and overexpression of the mitotic regulator Aurora kinase A (AURKA) drives tumor aneuploidy and chromosomal instability. These functions no...
- PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma
[作者：Molina, JR; Agarwal, NK; Morales, FC; Hayashi, Y; Aldape, KD; Cote, G; Georgescu, MM,期刊：Oncogene, 页码：1264-1274 , 文章类型： Article，,卷期：2012年31-10]
- The phosphatidylinositol-3-OH kinase (PI3K)-Akt pathway is activated in cancer by genetic or epigenetic events and efforts are under way to develop targeted therapies. phosphatase and tensin homolog deleted on chromosome...
- An ErbB-3 antibody, MP-RM-1, inhibits tumor growth by blocking ligand-dependent and independent activation of ErbB-3/Akt signaling
[作者：Sala, G; Traini, S; D'Egidio, M; Vianale, G; Rossi, C; Piccolo, E; Lattanzio, R; Piantelli, M; Tinari, N; Natali, PG; Muraro, R; Iacobelli, S,期刊：Oncogene, 页码：1275-1286 , 文章类型： Article，,卷期：2012年31-10]
- The ErbB receptors, such as ErbB-1 and ErbB-2, have been intensely pursued as targets for cancer therapeutics. Although initially efficacious in a subset of patients, drugs targeting these receptors led invariably to res...
- 1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma
[作者：Mackintosh, C; Ordonez, JL; Garcia-Dominguez, DJ; Sevillano, V; Llombart-Bosch, A; Szuhai, K; Scotlandi, K; Alberghini, M; Sciot, R; Sinnaeve, F; Hogendoorn, PCW; Picci, P; Knuutila, S; Dirksen, U; Debiec-Rychter, M; Schaefer, KL; de Alava, E,期刊：Oncogene, 页码：1287-1298 , 文章类型： Article，,卷期：2012年31-10]
- Despite extensive characterization of the role of the EWS-ETS fusions, little is known about secondary genetic alterations and their clinical contribution to Ewing sarcoma (ES). It has been demonstrated that the molecula...
- HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation
[作者：Haapa-Paananen, S; Kiviluoto, S; Waltari, M; Puputti, M; Mpindi, JP; Kohonen, P; Tynninen, O; Haapasalo, H; Joensuu, H; Perala, M; Kallioniemi, O,期刊：Oncogene, 页码：1299-1310 , 文章类型： Article，,卷期：2012年31-10]
- Malignant glioma is the most common brain tumor with 16 000 new cases diagnosed annually in the United States. We performed a systematic large-scale transcriptomics data mining study of 9783 tissue samples from the GeneS...
- DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD
[作者：Fu, K; Ren, H; Wang, Y; Fei, E; Wang, H; Wang, G,期刊：Oncogene, 页码：1311-1322 , 文章类型： Article，,卷期：2012年31-10]
- DJ-1 was initially identified as an oncogene product involved in human tumorigenesis in cooperation with Ras. Increased DJ-1 expression is associated with tumorigenesis in many cancers, whereas the loss of DJ-1 function ...
- JAK2(V617F) negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative neoplasms
[作者：Nakatake, M; Monte-Mor, B; Debili, N; Casadevall, N; Ribrag, V; Solary, E; Vainchenker, W; Plo, I,期刊：Oncogene, 页码：1323-1333 , 文章类型： Article，,卷期：2012年31-10]
- JAK2(V617F) is a gain of function mutation that promotes cytokine-independent growth of myeloid cells and accounts for a majority of myeloproliferative neoplasms (MPN). Mutations in p53 are rarely found in these diseases...
- A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation
[作者：Tognon, CE; Martin, MJ; Moradian, A; Trigo, G; Rotblat, B; Cheng, SWG; Pollard, M; Uy, E; Chow, C; Carboni, JM; Gottardis, MM; Pollak, M; Morin, GB; Sorensen, PHB,期刊：Oncogene, 页码：1334-1340 , 文章类型： Article，,卷期：2012年31-10]
- ETV6-NTRK3 (EN), a chimeric tyrosine kinase generated by t(12; 15) translocations, is a dominantly acting oncoprotein in diverse tumor types. We previously showed that insulin-like growth factor 1 receptor (IGF1R) is ess...
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