- MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells
[作者：Gu, L; Zhang, H; He, J; Li, J; Huang, M; Zhou, M,期刊：Oncogene, 页码：1342-1353 , 文章类型： Article，,卷期：2012年31-11]
- The MYCN gene has a critical role in determining the clinical behavior of neuroblastoma. Although it is known that genomic amplification occurs in high-risk subsets, it remains unclear how MYCN expression is regulated in...
- Sox2 expression in breast tumours and activation in breast cancer stem cells
[作者：Leis, O; Eguiara, A; Lopez-Arribillaga, E; Alberdi, MJ; Hernandez-Garcia, S; Elorriaga, K; Pandiella, A; Rezola, R; Martin, AG,期刊：Oncogene, 页码：1354-1365 , 文章类型： Article，,卷期：2012年31-11]
- The cancer stem cell (CSC) model does not imply that tumours are generated from transformed tissue stem cells. The target of transformation could be a tissue stem cell, a progenitor cell, or a differentiated cell that ac...
- Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis
[作者：Tho, LM; Libertini, S; Rampling, R; Sansom, O; Gillespie, DA,期刊：Oncogene, 页码：1366-1375 , 文章类型： Article，,卷期：2012年31-11]
- Chk1 is a key regulator of DNA damage checkpoint responses and genome stability in eukaryotes. To better understand how checkpoint proficiency relates to cancer development, we investigated the effects of genetic ablatio...
- Loss of EBP50 stimulates EGFR activity to induce EMT phenotypic features in biliary cancer cells
[作者：Claperon, A; Guedj, N; Mergey, M; Vignjevic, D; Desbois-Mouthon, C; Boissan, M; Saubamea, B; Paradis, V; Housset, C; Fouassier, L,期刊：Oncogene, 页码：1376-1388 , 文章类型： Article，,卷期：2012年31-11]
- Scaffold proteins form multiprotein complexes that are central to the regulation of intracellular signaling. The scaffold protein ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) is highly expressed at the plasma m...
- MicroRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1
[作者：Xu, Y; Zhao, F; Wang, Z; Song, Y; Luo, Y; Zhang, X; Jiang, L; Sun, Z; Miao, Z; Xu, H,期刊：Oncogene, 页码：1398-1407 , 文章类型： Article，,卷期：2012年31-11]
- Aberrant expression of miR-335 has been frequently reported in cancer studies, suggesting that there is a close correlation between miR-335 and cancer during its development, progression, metastasis and prognosis. The ex...
- Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin
[作者：Huertas, D; Soler, M; Moreto, J; Villanueva, A; Martinez, A; Vidal, A; Charlton, M; Moffat, D; Patel, S; McDermott, J; Owen, J; Brotherton, D; Krige, D; Cuthill, S; Esteller, M,期刊：Oncogene, 页码：1408-1418 , 文章类型： Article，,卷期：2012年31-11]
- The approval of histone deacetylase inhibitors for treatment of lymphoma subtypes has positioned histone modifications as potential targets for the development of new classes of anticancer drugs. Histones also undergo ph...
- GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells
[作者：Joha, S; Nugues, AL; Hetuin, D; Berthon, C; Dezitter, X; Dauphin, V; Mahon, FX; Roche-Lestienne, C; Preudhomme, C; Quesnel, B; Idziorek, T,期刊：Oncogene, 页码：1419-1430 , 文章类型： Article，,卷期：2012年31-11]
- The malignant phenotype of chronic myeloid leukemia (CML) is due to the abnormal tyrosine kinase activity of the BCR-ABL oncoprotein, which signals several downstream cell survival pathways, including phosphoinositide 3-...
- The proto-oncoprotein KR-POK represses transcriptional activation of CDKN1A by MIZ-1 through competitive binding
[作者：Lee, KM; Choi, WI; Koh, DI; Kim, YJ; Jeon, BN; Yoon, JH; Lee, CE; Kim, SH; Oh, J; Hur, MW,期刊：Oncogene, 页码：1442-1458 , 文章类型： Article，,卷期：2012年31-11]
- The BTB/POZ family of proteins has been implicated in multiple biological processes, including tumourigenesis, DNA damage responses and cell cycle progression and development. MIZ-1 (Myc-interacting zinc-finger protein 1...
- Deficiency of the macrophage growth factor CSF-1 disrupts pancreatic neuroendocrine tumor development
[作者：Pyonteck, SM; Gadea, BB; Wang, HW; Gocheva, V; Hunter, KE; Tang, LH; Joyce, JA,期刊：Oncogene, 页码：1459-1467 , 文章类型： Article，,卷期：2012年31-11]
- Tumor-associated macrophages have recently emerged as a key regulatory cell type during cancer progression, and have been found to promote tumor malignancy in the majority of studies performed to date. We show in this st...
- Identification of a novel pro-apoptotic role of NF-kappa B in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells
[作者：Jennewein, C; Karl, S; Baumann, B; Micheau, O; Debatin, KM; Fulda, S,期刊：Oncogene, 页码：1468-1474 , 文章类型： Article，,卷期：2012年31-11]
- We recently reported that nuclear factor-kappa B (NF-kappa B) promotes DNA damage-triggered apoptosis in glioblastoma, the most common brain tumor. In the present study, we investigated the role of NF-kappa B in death re...
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