- Molecular mechanisms of cisplatin resistance
[作者：Galluzzi, L; Senovilla, L; Vitale, I; Michels, J; Martins, I; Kepp, O; Castedo, M; Kroemer, G,期刊：Oncogene, 页码：1869-1883 , 文章类型： Review，,卷期：2012年31-15]
- Platinum-based drugs, and in particular cis-diamminedichloroplatinum(II) (best known as cisplatin), are employed for the treatment of a wide array of solid malignancies, including testicular, ovarian, head and neck, colo...
- Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases
[作者：Papagiannakopoulos, T; Friedmann-Morvinski, D; Neveu, P; Dugas, JC; Gill, RM; Huillard, E; Liu, C; Zong, H; Rowitch, DH; Barres, BA; Verma, IM; Kosik, KS,期刊：Oncogene, 页码：1884-1895 , 文章类型： Article，,卷期：2012年31-15]
- MicroRNAs (miRNAs) carry out post-transcriptional control of a multitude of cellular processes. Aberrant expression of miRNA can lead to diseases, including cancer. Gliomas are aggressive brain tumors that are thought to...
- Introduction of SV40ER and hTERT into mammospheres generates breast cancer cells with stem cell properties
[作者：Paranjape, AN; Mandal, T; Mukherjee, G; Kumar, MV; Sengupta, K; Rangarajan, A,期刊：Oncogene, 页码：1896-1909 , 文章类型： Article，,卷期：2012年31-15]
- Emerging evidence suggests that cancers arise in stem/progenitor cells. Yet, the requirements for transformation of these primitive cells remains poorly understood. In this study, we have exploited the 'mammosphere' syst...
- Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation
[作者：Fernandez, A; Squatrito, M; Northcott, P; Awan, A; Holland, EC; Taylor, MD; Nahle, Z; Kenney, AM,期刊：Oncogene, 页码：1923-1937 , 文章类型： Article，,卷期：2012年31-15]
- Radiation therapy remains the standard of care for many cancers, including the malignant pediatric brain tumor medulloblastoma. Radiation leads to long-term side effects, whereas radioresistance contributes to tumor recu...
- Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin
[作者：Berezov, A; Cai, Z; Freudenberg, JA; Zhang, H; Cheng, X; Thompson, T; Murali, R; Greene, MI; Wang, Q,期刊：Oncogene, 页码：1938-1948 , 文章类型： Article，,卷期：2012年31-15]
- Survivin is a member of the inhibitor of apoptosis protein family and has an essential role in mitosis. Survivin is overexpressed in a large variety of human cancers and represents an attractive target for cancer therapy...
- AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
[作者：Astle, MV; Hannan, KM; Ng, PY; Lee, RS; George, AJ; Hsu, AK; Haupt, Y; Hannan, RD; Pearson, RB,期刊：Oncogene, 页码：1949-1962 , 文章类型： Article，,卷期：2012年31-15]
- The phosphatidylinositol 3-kinase (PI3K)/AKT and RAS oncogenic signalling modules are frequently mutated in sporadic human cancer. Although each of these pathways has been shown to play critical roles in driving tumour g...
- Stabilization of phenotypic plasticity through mesenchymal-specific DNA hypermethylation in cancer cells
[作者：Kurasawa, Y; Kozaki, K; Pimkhaokham, A; Muramatsu, T; Ono, H; Ishihara, T; Uzawa, N; Imoto, I; Amagasa, T; Inazawa, J,期刊：Oncogene, 页码：1963-1974 , 文章类型： Article，,卷期：2012年31-15]
- The epithelial-mesenchymal transition (EMT) has a crucial role in normal and disease processes including tumor progression. In this study, we first classified epithelial-like and mesenchymal-like oral squamous cell carci...
- Regulation of APC/C(Cdc20) activity by RASSF1A-APC/C(Cdc20) circuitry
[作者：Chow, C; Wong, N; Pagano, M; Lun, SWM; Nakayama, KI; Nakayama, K; Lo, KW,期刊：Oncogene, 页码：1975-1987 , 文章类型： Article，,卷期：2012年31-15]
- RASSF1A is a key tumor-suppressor gene that is often inactivated in a wide variety of solid tumors. Studies have illustrated that RASSF1A plays vital roles in the regulation of cell-cycle progression and functions as a g...
- Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer
[作者：Taniguchi, H; Jacinto, FV; Villanueva, A; Fernandez, AF; Yamamoto, H; Carmona, FJ; Puertas, S; Marquez, VE; Shinomura, Y; Imai, K; Esteller, M,期刊：Oncogene, 页码：1988-1994 , 文章类型： Article，,卷期：2012年31-15]
- The Kruppel-like factor (KLF) proteins are multitasked transcriptional regulators with an expanding tumor suppressor function. KLF2 is one of the prominent members of the family because of its diminished expression in ma...
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