- Deubiquitinases in cancer: new functions and therapeutic options
[作者：Fraile, JM; Quesada, V; Rodriguez, D; Freije, JMP; Lopez-Otin, C,期刊：Oncogene, 页码：2373-2388 , 文章类型： Review，,卷期：2012年31-19]
- Deubiquitinases (DUBs) have fundamental roles in the ubiquitin system through their ability to specifically deconjugate ubiquitin from targeted proteins. The human genome encodes at least 98 DUBs, which can be grouped in...
- TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer
[作者：Shih, MC; Chen, JY; Wu, YC; Jan, YH; Yang, BM; Lu, PJ; Cheng, HC; Huang, MS; Yang, CJ; Hsiao, M; Lai, JM,期刊：Oncogene, 页码：2389-2400 , 文章类型： Article，,卷期：2012年31-19]
- We integrated four gene expression profile data sets, namely two different pair-matched stage I lung adenocarcinoma data sets, secondary metastatic tumors vs benign tumors and lung tumor metastasizes to the brain, and we...
- Connective tissue growth factor modulates oral squamous cell carcinoma invasion by activating a miR-504/FOXP1 signalling
[作者：Yang, MH; Lin, BR; Chang, CH; Chen, ST; Lin, SK; Kuo, MYP; Jeng, YM; Kuo, ML; Chang, CC,期刊：Oncogene, 页码：2401-2411 , 文章类型： Article，,卷期：2012年31-19]
- Connective tissue growth factor (CTGF) is a multifunctional secreted protein, and it has been shown either to promote or suppress tumor progression among different kinds of cancers. Here, we investigated the role of CTGF...
- A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression
[作者：Zeineldin, M; Cunningham, J; McGuinness, W; Alltizer, P; Cowley, B; Blanchat, B; Xu, W; Pinson, D; Neufeld, KL,期刊：Oncogene, 页码：2423-2437 , 文章类型： Article，,卷期：2012年31-19]
- Mutation of the tumor suppressor adenomatous polyposis coli (APC) is considered an initiating step in the genesis of the vast majority of colorectal cancers. APC inhibits the Wnt-signaling pathway by targeting the proto-...
- Self-renewal gene tracking to identify tumour-initiating cells associated with metastatic potential
[作者：Darini, CY; Pisani, DF; Hofman, P; Pedeutour, F; Sudaka, I; Chomienne, C; Dani, C; Ladoux, A,期刊：Oncogene, 页码：2438-2449 , 文章类型： Article，,卷期：2012年31-19]
- Tumour-initiating cells (TICs) are rare cancer cells isolated from tumours of different origins including high-grade tumours that sustain neoplasic progression and development of metastatic disease. They harbour deregula...
- Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest
[作者：Russell, P; Hennessy, BT; Li, J; Carey, MS; Bast, RC; Freeman, T; Venkitaraman, AR,期刊：Oncogene, 页码：2450-2460 , 文章类型： Article，,卷期：2012年31-19]
- Anti-mitotic chemotherapeutic agents such as taxanes activate the spindle assembly checkpoint (SAC) to arrest anaphase onset, but taxane-exposed cells eventually undergo slippage to exit mitosis. The therapeutic efficacy...
- Hypoxia and MITF control metastatic behaviour in mouse and human melanoma cells
[作者：Cheli, Y; Giuliano, S; Fenouille, N; Allegra, M; Hofman, V; Hofman, P; Bahadoran, P; Lacour, JP; Tartare-Deckert, S; Bertolotto, C; Ballotti, R,期刊：Oncogene, 页码：2461-2470 , 文章类型： Article，,卷期：2012年31-19]
- Melanomas are very aggressive neoplasms with notorious resistance to therapeutics. It was recently proposed that the remarkable phenotypic plasticity of melanoma cells allows for the rapid development of both resistance ...
- Hic-5 controls BMP4 responses in prostate cancer cells through interacting with Smads 1, 5 and 8
[作者：Shola, DTN; Wang, H; Wahdan-Alaswad, R; Danielpour, D,期刊：Oncogene, 页码：2480-2490 , 文章类型： Article，,卷期：2012年31-19]
- Hydrogen peroxide-inducible clone-5 (Hic-5, or androgen receptor-associated protein 55) is a transforming growth factor-beta-inducible LIM protein whose deregulation is implicated in the progression of prostate cancer. H...
- Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production
[作者：Ward, PS; Cross, JR; Lu, C; Weigert, O; Abel-Wahab, O; Levine, RL; Weinstock, DM; Sharp, KA; Thompson, CB,期刊：Oncogene, 页码：2491-2498 , 文章类型： Article，,卷期：2012年31-19]
- Mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) or its mitochondrial homolog IDH2 can lead to R(-)-2-hydroxyglutarate (2HG) production. To date, mutations in three active site arginine residues, IDH1 R132, IDH2 ...
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