- Checkpoint control and cancer
[作者：Medema, RH; Macurek, L,期刊：Oncogene, 页码：2601-2613 , 文章类型： Review，,卷期：2012年31-21]
- DNA-damaging therapies represent the most frequently used non-surgical anticancer strategies in the treatment of human tumors. These therapies can kill tumor cells, but at the same time they can be particularly damaging ...
- CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGF beta signaling
[作者：Lo, PK; Kanojia, D; Liu, X; Singh, UP; Berger, FG; Wang, Q; Chen, H,期刊：Oncogene, 页码：2614-2626 , 文章类型： Article，,卷期：2012年31-21]
- Human epidermal growth factor receptor 2 (HER2)/Neu is overexpressed in 20-30% of breast cancers and associated with aggressive phenotypes and poor prognosis. For deciphering the role of HER2/Neu in breast cancer, mouse ...
- Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum
[作者：Gajate, C; Matos-da-Silva, M; Dakir, EH; Fonteriz, RI; Alvarez, J; Mollinedo, F,期刊：Oncogene, 页码：2627-2639 , 文章类型： Article，,卷期：2012年31-21]
- Pancreatic cancer remains as one of the most deadly cancers, and responds poorly to current therapies. The prognosis is extremely poor, with a 5-year survival of less than 5%. Therefore, search for new effective therapeu...
- Somatic LMCD1 mutations promoted cell migration and tumor metastasis in hepatocellular carcinoma
[作者：Chang, CY; Lin, SC; Su, WH; Ho, CM; Jou, YS,期刊：Oncogene, 页码：2640-2652 , 文章类型： Article，,卷期：2012年31-21]
- Common genetic alteration in cancer genomes is implicated for embracing an aberrant cancer gene participated in tumor progression. In this study, we identified a somatic mutated LIM and cysteine-rich domains-1 (LMCD1) as...
- Inhibition of beta-catenin signaling by nongenomic action of orphan nuclear receptor Nur77
[作者：Sun, Z; Cao, X; Jiang, MM; Qiu, Y; Zhou, H; Chen, L; Qin, B; Wu, H; Jiang, F; Chen, J; Liu, J; Dai, Y; Chen, HF; Hu, QY; Wu, Z; Zeng, JZ; Yao, XS; Zhang, XK,期刊：Oncogene, 页码：2653-2667 , 文章类型： Article，,卷期：2012年31-21]
- Dysregulation of beta-catenin turnover due to mutations of its regulatory proteins including adenomatous polyposis coli (APC) and p53 is implicated in the pathogenesis of cancer. Thus, intensive effort is being made to s...
- Syntenin-mediated regulation of Sox4 proteasomal degradation modulates transcriptional output
[作者：Beekman, JM; Vervoort, SJ; Dekkers, F; van Vessem, ME; Vendelbosch, S; Brugulat-Panes, A; van Loosdregt, J; Braat, AK; Coffer, PJ,期刊：Oncogene, 页码：2668-2679 , 文章类型： Article，,卷期：2012年31-21]
- The transcription factor Sox4 is aberrantly expressed in many human tumors and can modulate tumorigenesis and metastases of murine tumors in vivo. However, mechanisms that control Sox4 function remain poorly defined. It ...
- Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma
[作者：Torchia, EC; Caulin, C; Acin, S; Terzian, T; Kubick, BJ; Box, NF; Roop, DR,期刊：Oncogene, 页码：2680-2690 , 文章类型： Article，,卷期：2012年31-21]
- Clinical observations, as well as data obtained from the analysis of genetically engineered mouse models, firmly established the gain-of-function (GOF) properties of certain p53 mutations. However, little is known about ...
- Dynamin 2 mediates PDGFR alpha-SHP-2-promoted glioblastoma growth and invasion
[作者：Feng, H; Liu, KW; Guo, P; Zhang, P; Cheng, T; McNiven, MA; Johnson, GR; Hu, B; Cheng, SY,期刊：Oncogene, 页码：2691-2702 , 文章类型： Article，,卷期：2012年31-21]
- Dynamin 2 (Dyn2), a large GTPase, is involved in receptor tyrosine kinase (RTK)-promoted cell migration. However, the molecular mechanisms by which Dyn2 regulates RTK-induced cell migration have not been established. Rec...
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