- Common Mechanistic Features among Metallo-beta-lactamases A COMPUTATIONAL STUDY OF AEROMONAS HYDROPHILA CphA ENZYME
[作者：Simona, F; Magistrato, A; Dal Peraro, M; Cavalli, A; Vila, AJ; Carloni, P,期刊：Journal of Biological Chemistry, 页码：28164-28171 , 文章类型： Article，,卷期：2009年284-41]
- Metallo-beta-lactamases (M beta Ls) constitute an increasingly serious clinical threat by giving rise to beta-lactam antibiotic resistance. They accommodate in their catalytic pocket one or two zinc ions, which are respo...
- At Increases Sarcoplasmic Reticulum Ca2+ Cycling by Direct Phosphorylation of Phospholamban at Thr(17)
[作者：Catalucci, D; Latronico, MVG; Ceci, M; Rusconi, F; Young, HS; Gallo, P; Santonastasi, M; Bellacosa, A; Brown, JH; Condorelli, G,期刊：Journal of Biological Chemistry, 页码：28180-28187 , 文章类型： Article，,卷期：2009年284-41]
- Cardiomyocytes adapt to physical stress by increasing their size while maintaining cell function. The serine/threonine kinase Akt plays a critical role in this process of adaptation. We previously reported that transgeni...
- Adenovirus E1A Inhibits SCFFbw7 Ubiquitin Ligase
[作者：Isobe, T; Hattori, T; Kitagawa, K; Uchida, C; Kotake, Y; Kosugi, I; Oda, T; Kitagawa, M,期刊：Journal of Biological Chemistry, 页码：27766-27779 , 文章类型： Article，,卷期：2009年284-41]
- The SCFFbw7 ubiquitin ligase complex plays important roles in cell growth, survival, and differentiation via the ubiquitin-proteasome-mediated regulation of protein stability. Fbw7 (also known as Fbxw7, Sel-10, hCdc4, or...
- C1q Tumor Necrosis Factor alpha-related Protein Isoform 5 Is Increased in Mitochondrial DNA-depleted Myocytes and Activates AMP-activated Protein Kinase
[作者：Park, SY; Choi, JH; Ryu, HS; Pak, YK; Park, KS; Lee, HK; Lee, W,期刊：Journal of Biological Chemistry, 页码：27780-27789 , 文章类型： Article，,卷期：2009年284-41]
- Depletion of mtDNA in myocytes causes insulin resistance and alters nuclear gene expression that may be involved in rescuing processes against cellular stress. Here we show that the expression of C1q tumor necrosis facto...
- The MitCHAP-60 Disease Is Due to Entropic Destabilization of the Human Mitochondrial Hsp60 Oligomer
[作者：Parnas, A; Nadler, M; Nisemblat, S; Horovitz, A; Mandel, H; Azem, A,期刊：Journal of Biological Chemistry, 页码：28198-28203 , 文章类型： Article，,卷期：2009年284-41]
- The 60-kDa heat shock protein (mHsp60) is a vital cellular complex that mediates the folding of many of the mitochondrial proteins. Its function is executed in cooperation with the co-chaperonin, mHsp 10, and requires AT...
- Reduction of Lysyl Hydroxylase 3 Causes Deleterious Changes in the Deposition and Organization of Extracellular Matrix
[作者：Risteli, M; Ruotsalainen, H; Salo, AM; Sormunen, R; Sipila, L; Baker, NL; Lamande, SR; Vimpari-Kauppinen, L; Myllyla, R,期刊：Journal of Biological Chemistry, 页码：28204-28211 , 文章类型： Article，,卷期：2009年284-41]
- Lysyl hydroxylase 3 (LH3) is a multifunctional enzyme possessing lysyl hydroxylase, collagen galactosyltransferase, and glucosyltransferase (GGT) activities. We report here an important role for LH3 in the organization o...
- TSC2 Deficiency Increases PTEN via H1F1 alpha
[作者：Mahimainathan, L; Ghosh-Choudhury, N; Venkatesan, B; Das, F; Mandal, CC; Dey, N; Habib, SL; Kasinath, BS; Abboud, HE; Choudhury, GG,期刊：Journal of Biological Chemistry, 页码：27790-27798 , 文章类型： Article，,卷期：2009年284-41]
- Substantial evidence suggests roles of TSC2 and PTEN in the development of cancer predisposition syndromes. Loss of TSC2 results in benign tumors, neurological disorders, and angiomyolipomas. We found that PTEN mRNA and ...
- Interrelations between C-4 Ketogenesis, C-5 Ketogenesis, and Anaplerosis in the Perfused Rat Liver
[作者：Deng, S; Zhang, GF; Kasumov, T; Roe, CR; Brunengraber, H,期刊：Journal of Biological Chemistry, 页码：27799-27807 , 文章类型： Article，,卷期：2009年284-41]
- We investigated the interrelations between C, ketogenesis (production of beta-hydroxybutyrate + acetoacetate), C-5 ketogenesis (production of beta-hydroxypentanoate + beta-ketopentanoate), and anaplerosis in isolated rat...
- Interferon-resistant Daudi Cell Line with a Stat2 Defect Is Resistant to Apoptosis Induced by Chemotherapeutic Agents
[作者：Du, ZY; Fan, MY; Kim, JG; Eckerle, D; Lothstein, L; Wei, L; Pfeffer, LM,期刊：Journal of Biological Chemistry, 页码：27808-27815 , 文章类型： Article，,卷期：2009年284-41]
- Interferon-alpha (IFN alpha) has shown promise in the treatment of various cancers. However, the development of IFN resistance is a significant drawback. Using conditions that mimic in vivo selection of IFN-resistant cel...
- The Terminal Region of beta-Catenin Promotes Stability by Shielding the Armadillo Repeats from the Axin-scaffold Destruction Complex
[作者：Mo, R; Chew, TL; Maher, MT; Bellipanni, G; Weinberg, ES; Gottardi, CJ,期刊：Journal of Biological Chemistry, 页码：28222-28231 , 文章类型： Article，,卷期：2009年284-41]
- Post-translational stabilization of beta-catenin is a key step in Wnt signaling, but the features of beta-catenin required for stabilization are incompletely understood. We show that forms of beta-catenin lacking the uns...
- The Ubiquitin-like Protein LC3 Regulates the Rho-GEF Activity of AKAP-Lbc
[作者：Baisamy, L; Cavin, S; Jurisch, N; Diviani, D,期刊：Journal of Biological Chemistry, 页码：28232-28242 , 文章类型： Article，,卷期：2009年284-41]
- AKAP-Lbc is a member of the A-kinase anchoring protein (AKAP) family that has been recently associated with the development of pathologies, such as cardiac hypertrophy and cancer. We have previously demonstrated that, at...
- N-alpha-Tosyl-L-phenylalanine Chloromethyl Ketone Induces Caspase-dependent Apoptosis in Transformed Human B Cell Lines with Transcriptional Down-regulation of Anti-apoptotic HS1-associated Protein X-1
[作者：Jitkaew, S; Trebinska, A; Grzybowska, E; Carlsson, G; Nordstrom, A; Lehtio, J; Frojmark, AS; Dahl, N; Fadeel, B,期刊：Journal of Biological Chemistry, 页码：27827-27837 , 文章类型： Article，,卷期：2009年284-41]
- N-alpha-ToSyl-L-phenylalanine chloromethylketone (TPCK) has been widely used to investigate signal transduction pathways that are involved in gene expression and cell survival/cell death. However, contradictory effects o...
- Single Chain Variable Fragment against Nicastrin Inhibits the gamma-Secretase Activity
[作者：Hayashi, I; Takatori, S; Urano, Y; Iwanari, H; Isoo, N; Osawa, S; Fukuda, MA; Kodama, T; Hamakubo, T; Li, T; Wong, PC; Tomita, T; Iwatsubo, T,期刊：Journal of Biological Chemistry, 页码：27838-27847 , 文章类型： Article，,卷期：2009年284-41]
- gamma-Secretase is a membrane protein complex that catalyzes intramembrane proteolysis of a variety of substrates including the amyloid beta precursor protein of Alzheimer disease. Nicastrin (NCT), a single-pass membrane...
- Opposing Effects of KLF5 on the Transcription of MYC in Epithelial Proliferation in the Context of Transforming Growth Factor beta
[作者：Guo, P; Dong, XY; Zhao, KW; Sun, XD; Li, QN; Dong, JT,期刊：Journal of Biological Chemistry, 页码：28243-28252 , 文章类型： Article，,卷期：2009年284-41]
- The proto-oncogene MYC plays a critical role in cell proliferation and tumorigenesis, and its down-regulation by transforming growth factor beta (TGF beta) signaling is necessary for TGF beta to inhibit cell proliferatio...
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