- TMP21 Transmembrane Domain Regulates gamma-Secretase Cleavage
[作者:Pardossi-Piquard, R; Bohm, C; Chen, FS; Kanemoto, S; Checler, F; Schmitt-Ulms, G; George-Hyslop, PS; Fraser, PE,期刊:Journal of Biological Chemistry, 页码:28634-28641 , 文章类型: Article,,卷期:2009年284-42]
- TMP21 has been shown to be associated with the gamma-secretase complex and can specifically regulate gamma-cleavage without affecting epsilon-mediated proteolysis. To explore the basis of this activity, TMP21 modulation ...
- Paraquat Toxicity Induced by Voltage-dependent Anion Channel 1 Acts as an NADH-dependent Oxidoreductase
[作者:Shimada, H; Hirai, KI; Simamura, E; Hatta, T; Iwakiri, H; Mizuki, K; Hatta, T; Sawasaki, T; Matsunaga, S; Endo, Y; Shimizu, S,期刊:Journal of Biological Chemistry, 页码:28642-28649 , 文章类型: Article,,卷期:2009年284-42]
- Paraquat (PQ), a herbicide used worldwide, causes fatal injury to organs upon high dose ingestion. Treatments for PQ poisoning areunreliable, and numerous deaths have been attributed inappropriate usage of the agent. It ...
- CYP7B1: One Cytochrome P450, Two Human Genetic Diseases, and Multiple Physiological Functions
[作者:Stiles, AR; McDonald, JG; Bauman, DR; Russell, DW,期刊:Journal of Biological Chemistry, 页码:28485-28489 , 文章类型: Review,,卷期:2009年284-42]
- The CYP7B1 cytochrome P450 enzyme hydroxylates carbons 6 and 7 of the B ring of oxysterols and steroids. Hydroxylation reduces the biological activity of these substrates and facilitates their conversion to end products ...
- Phospholipid Association Is Essential for Dynamin-related Protein Mgm1 to Function in Mitochondrial Membrane Fusion
[作者:Rujiviphat, J; Meglei, G; Rubinstein, JL; McQuibban, GA,期刊:Journal of Biological Chemistry, 页码:28682-28686 , 文章类型: Article,,卷期:2009年284-42]
- Mgm1, the yeast ortholog of mammalian OPA1, is a key component in mitochondrial membrane fusion and is required for maintaining mitochondrial dynamics and morphology. We showed recently that the purified short isoform of...
- The N-terminal Domain of Drosophila Gram-negative Binding Protein 3 (GNBP3) Defines a Novel Family of Fungal Pattern Recognition Receptors
[作者:Mishima, Y; Quintin, J; Aimanianda, V; Kellenberger, C; Coste, F; Clavaud, C; Hetru, C; Hoffmann, JA; Latge, JP; Ferrandon, D; Roussel, A,期刊:Journal of Biological Chemistry, 页码:28687-28697 , 文章类型: Article,,卷期:2009年284-42]
- Gram-negative binding protein 3 (GNBP3), a pattern recognition receptor that circulates in the hemolymph of Drosophila, is responsible for sensing fungal infection and triggering Toll pathway activation. Here, we report ...
- Loss of TMEM16A Causes a Defect in Epithelial Ca2+-dependent Chloride Transport
[作者:Ousingsawat, J; Martins, JR; Schreiber, R; Rock, JR; Harfe, BD; Kunzelmann, K,期刊:Journal of Biological Chemistry, 页码:28698-28703 , 文章类型: Article,,卷期:2009年284-42]
- Molecular identification of the Ca2+-dependent chloride channel TMEM16A (ANO1) provided a fundamental step in understanding Ca2+-dependent Cl- secretion in epithelia. TMEM16A is an intrinsic constituent of Ca2+-dependent...
- Heparan Sulfate Proteoglycan Modulation of Wnt5A Signal Transduction in Metastatic Melanoma Cells
[作者:O'Connell, MP; Fiori, JL; Kershner, EK; Frank, BP; Indig, FE; Taub, DD; Hoek, KS; Weeraratna, AT,期刊:Journal of Biological Chemistry, 页码:28704-28712 , 文章类型: Article,,卷期:2009年284-42]
- Heparan sulfate proteoglycans (HSPGs) are important modulators for optimizing signal transduction of many pathways, including the Wnt pathways. We demonstrate that HSPG glycosaminoglycan levels increased with increasing ...
- GATA3 Is Selectively Expressed in the Trophectoderm of Peri-implantation Embryo and Directly Regulates Cdx2 Gene Expression
[作者:Home, P; Ray, S; Dutta, D; Bronshteyn, I; Larson, M; Paul, S,期刊:Journal of Biological Chemistry, 页码:28729-28737 , 文章类型: Article,,卷期:2009年284-42]
- During early mammalian development, genesis of the first two cell lineages, inner cell mass (ICM) and trophectoderm (TE), is dependent upon functions of key transcription factors that are expressed in a regulated and spa...
- MqsR, a Crucial Regulator for Quorum Sensing and Biofilm Formation, Is a GCU-specific mRNA Interferase in Escherichia coli
[作者:Yamaguchi, Y; Park, JH; Inouye, M,期刊:Journal of Biological Chemistry, 页码:28746-28753 , 文章类型: Article,,卷期:2009年284-42]
- The mqsR gene has been shown to be positively regulated by the quorum-sensing autoinducer AI-2, which in turn activates a two-component system, the qseB-qseC operon. This operon plays an important role in biofilm formati...
- Cdc2-mediated Phosphorylation of CLIP-170 Is Essential for Its Inhibition of Centrosome Reduplication
[作者:Yang, XM; Li, HC; Liu, XS; Deng, AP; Liu, XQ,期刊:Journal of Biological Chemistry, 页码:28775-28782 , 文章类型: Article,,卷期:2009年284-42]
- CLIP-170, the founding member of microtubule "plus ends tracking" proteins, is involved in many critical microtubule-related functions, including recruitment of dynactin to the microtubule plus ends and formation of kine...
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