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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   Three Ring Posttranslational Circuses: Insertion of Oxazoles, Thiazoles, and Pyridines into Protein-Derived Frameworks [作者：WALSH CHRISTOPHER T; MALCOLMSON STEVEN J; YOUNG TRAVIS S,期刊：ACS CHEMICAL BIOLOGY, 页码：429-442 , 文章类型： Article，,卷期：2012年7-3] Nitrogen heterocycles are the key functional and structural elements in both RNA and DNA, in half a dozen of the most important coenzymes, and in many synthetic drug scaffolds. On the other hand, only 3 of 20 proteinogen... Current Chemical Biology Approaches to Interrogate Protein Methyltransferases [作者：LUO MINKUI,期刊：ACS CHEMICAL BIOLOGY, 页码：443-463 , 文章类型： Review，,卷期：2012年7-3] Protein methyltransferases (PMTs) play various physiological and pathological roles through methylating histone and nonhistone targets. However, most PMTs including more than 60 human PMTs remain to be fully characterize... Releasable SNAP-tag Probes for Studying Endocytosis and Recycling [作者：COLE NELSON B; DONALDSON JULIE G,期刊：ACS CHEMICAL BIOLOGY, 页码：464-469 , 文章类型： Article，,卷期：2012年7-3] Site-specific labeling of cellular proteins with chemicals probes is a powerful tool for live cell imaging of biological processes. One popular system, known as the SNAP tag is based on an engineered variant of the 20-kD... Inhibitors of Aminoglycoside Resistance Activated in Cells [作者：VONG KENWARD; TAM INGRID S; YAN XUXU; AUCLAIR KARINE,期刊：ACS CHEMICAL BIOLOGY, 页码：470-475 , 文章类型： Article，,卷期：2012年7-3] The most common mechanism of resistance to aminoglycoside antibiotics entails bacterial expression of drug-metabolizing enzymes, such as the clinically widespread aminoglycoside N-6'-acetyltransferase (AAC(6). Aminoglyco... Anisotropy of Chemical Bonds in Collagen Molecules Studied by X-ray Absorption Near-Edge Structure (XANES) Spectroscopy [作者：LAM RAYMOND S K; METZLER REBECCA A; GILBERT PUPA U P A; BENIASH ELIA,期刊：ACS CHEMICAL BIOLOGY, 页码：476-480 , 文章类型： Article，,卷期：2012年7-3] Collagen type I fibrils are the major building blocks of connective tissues. Collagen fibrils are anisotropic supramolecular structures, and their orientation can be revealed by polarized light microscopy and vibrational... Engineering Transaldolase in Pichia stipitis to Improve Bioethanol Production [作者：CHEN SHANHE; HWANG DERREN; CHEN GANHONG; HSU NINGSHIAN; WU YINGTA; LI TSUNGLIN; WONG CHIHUEY,期刊：ACS CHEMICAL BIOLOGY, 页码：481-486 , 文章类型： Article，,卷期：2012年7-3] In our effort to improve the efficiency and yield of xylose-to-ethanol bioconversion in Pichia stipitis, the transaldolase (TAL) in the pentose phosphate pathway was identified as a rate-limiting enzyme for improvement. ... Targeting Diverse Signaling Interaction Sites Allows the Rapid Generation of Bivalent Kinase Inhibitors [作者：HILL ZACHARY B; PERERA B GAYANI K; ANDREWS SIMEON S; MALY DUSTIN J,期刊：ACS CHEMICAL BIOLOGY, 页码：487-495 , 文章类型： Article，,卷期：2012年7-3] The identification of potent and selective modulators of protein kinase function remains a challenge, and new strategies are needed for generating these useful ligands. Here, we describe the generation of bivalent inhibi... Chemical Correction of Pre-mRNA Splicing Defects Associated with Sequestration of Muscleblind-like 1 Protein by Expanded r(CAG)-Containing Transcripts [作者：KUMAR AMIT; PARKESH RAMAN; SZNAJDER LUKASZ J; CHILDSDISNEY JESSICA L; SOBCZAK KRZYSZTOF; DISNEY MATTHEW D,期刊：ACS CHEMICAL BIOLOGY, 页码：496-505 , 文章类型： Article，,卷期：2012年7-3] Recently, it was reported that expanded r(CAG) triplet repeats (r(CAG)(exp)) associated with untreatable neurological diseases cause pre-mRNA mis-splicing likely due to sequestration of muscleblind-like 1 (MBNL1) splicin... First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G [作者：LI MING; SHANDILYA SHIVENDER M D; CARPENTER MICHAEL A; RATHORE ANURAG; BROWN WILLIAM L; PERKINS ANGELA L; HARKI DANIEL A; SOLBERG JONATHAN; HOOK DEREK J; PANDEY KRISHAN K; PARNIAK MICHAEL A; JOHNSON JEFFREY R; KROGAN NEVAN J; SOMASUNDARAN MOHAN; ALI AKBAR; SCHIFFER CELIA A; HARRIS REUBEN S,期刊：ACS CHEMICAL BIOLOGY, 页码：506-517 , 文章类型： Article，,卷期：2012年7-3] APOBEC3G is a single-stranded DNA cytosine deaminase that Comprises part of the innate immune response to viruses and transposons. Although APOBEC3G is the prototype for understanding the larger mammalian polynucleotide ... Small-Molecule-Modified Surfaces Engage Cells through the alpha(v)beta(3) Integrin [作者：KLIM JOSEPH R; FOWLER ANTHONY J; COURTNEY ADAM H; WRIGHTON PAUL J; SHERIDAN RACHAEL T C; WONG MARGARET L; KIESSLING LAURA L,期刊：ACS CHEMICAL BIOLOGY, 页码：518-525 , 文章类型： Article，,卷期：2012年7-3] Integrins play myriad and vital roles in development and disease. They connect a cell with its surroundings and transmit chemical and mechanical signals across the plasma membrane to the cell's interior. Dissecting their... Identification of Influenza Endonuclease Inhibitors Using a Novel Fluorescence Polarization Assay [作者：BAUGHMAN BRANDI M; SLAVISH P JAKE; DUBOIS REBECCA M; BOYD VINCENT A; WHITE STEPHEN W; WEBB THOMAS R,期刊：ACS CHEMICAL BIOLOGY, 页码：526-534 , 文章类型： Article，,卷期：2012年7-3] Influenza viruses have been responsible for the largest pandemics in the previous century. Although vaccination and prophylactic antiviral therapeutics are the primary defense against influenza virus, there is a pressing... Substrate/Product-Targeted NMR Monitoring of Pyrimidine Catabolism and Its Inhibition by a Clinical Drug [作者：YAMADA HISATSUGU; MIZUSAWA KEIGO; IGARASHI RYUJI; TOCHIO HIDEHITO; SHIRAKAWA MASAHIRO; TABATA YASUHIKO; KIMURA YU; KONDO TERUYUKI; AOYAMA YASUHIRO; SANDO SHINSUKE,期刊：ACS CHEMICAL BIOLOGY, 页码：535-542 , 文章类型： Article，,卷期：2012年7-3] We report the application of one-dimensional triple-resonance NMR to metabolic analysis and thereon-based evaluation of drug activity. Doubly C-13/N-15-labeled uracil ([(15)N1,(13)C6]-uracil) was prepared. Its catabolic ... Carbon-Fiber Microelectrode Amperometry Reveals Sickle-Cell-Induced Inflammation and Chronic Morphine Effects on Single Mast Cells [作者：MANNING BENJAMIN M; HEBBEL ROBERT P; GUPTA KALPNA; HAYNES CHRISTY L,期刊：ACS CHEMICAL BIOLOGY, 页码：543-551 , 文章类型： Article，,卷期：2012年7-3] Sickle cell disease, caused by a mutation of hemoglobin, is characterized by a complex pathophysiology including an important inflammatory component. Mast cells are tissue-resident leukocytes known to influence a range o... Mechanism of Drug Resistance of Hemagglutinin of Influenza Virus and Potent Scaffolds Inhibiting Its Function [作者：YANAGITA HIROSHI; YAMAMOTO NORIO; FUJI HIDEYOSHI; LIU XINLI; OGATA MASAKAZU; YOKOTA MIZUHO; TAKAKU HIROSHI; HASEGAWA HIDEKI; ODAGIRI TAKATO; TASHIRO MASATO; HOSHINO TYUJI,期刊：ACS CHEMICAL BIOLOGY, 页码：552-562 , 文章类型： Article，,卷期：2012年7-3] Highly pathogenic influenza viruses have become a global threat to humans. It is important to select an affective therapeutic option suitable for the subtypes in an epidemics or pandemic. To increase the options, the dev... Selective Small Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG) [作者：FINCH KRISTIN E; KNEZEVIC CLAIRE E; NOTTBOHM AMANDA C; PARTLOW KATHRYN C; HERGENROTHER PAUL J,期刊：ACS CHEMICAL BIOLOGY, 页码：563-570 , 文章类型： Article，,卷期：2012年7-3] The poly(ADP-ribose) (PAR) post-translational modification is essential for diverse cellular functions, including regulation of transcription, response to DNA damage, and mitosis. Cellular PAR is predominantly synthesize... Structure Guided Understanding of NAD(+) Recognition in Bacterial DNA Ligases [作者：LAHIRI SUSHMITA D; GU RONGFANG; GAO NING; KARANTZENI IRENE; WALKUP GRANT K; MILLS SCOTT D,期刊：ACS CHEMICAL BIOLOGY, 页码：571-580 , 文章类型： Article，,卷期：2012年7-3] NAD(+)-dependent DNA ligases (LigA) are essential bacterial enzymes that catalyze phosphodiester bond formation during DNA replication and repair processes. Phosphodiester bond formation proceeds through a 3-step reactio...