Catumaxomab (Removab (R)) is a trifunctional antibody that simultaneously activates T cells and accessory immune cells to destroy target tumor cells possessing the surface antigen epithelial cell adhesion molecule (Ep...

CP-751871, generated using the former Abgenix's (now Amgen) XenoMouse (R) technology, is a fully human IgG(2) antibody with high binding affinity for the human insulin-like growth factor 1 receptor (IGF-1R). Combinati...

The profound toxic effects of conventional cancer therapies such as chemo- and radiotherapy and the nonspecific side effects of small-molecule inhibitors of signaling proteins mandate more effective and preferably non...

Heat shock proteins (HSPs) are highly conserved stress-induced proteins which function as chaperones for trafficking peptides inside different cellular compartments and delivering peptides. Tumor-derived HSP-peptide c...

Tumor immunotherapy has advanced over the past decade due to the achievement of a better understanding of the immune system and the adoption of new approaches that attempt to take advantage of the interactions of the ...

Cardiovascular disease is the major cause of death worldwide. Apart from the traditional risk factors of smoking, hypertension and diabetes, high homocysteine plasma concentrations have also been suggested as a factor...

Alzheimer's disease (AD) is a progressive neurodegenerative disorder which is the principal cause of dementia throughout the world and the fourth cause of death in developed countries. The pathological hallmarks of th...

The osteopetroses are a heterogeneous group of sclerosing bone dysplasias with an increased bone density due to an osteoclast defect, with consequently recurrent fractures. Different forms have been described with rad...

Urinary incontinence is a common condition associated with the involuntary loss of urine which can be a social and/or hygienic handicap. Urination involves a complex and balanced action of nerves, muscles of the urina...

Diabetes UK held its annual professional conference on March 5-7, 2008, in Glasgow, U.K. The meeting was devoted to developments in different areas of diabetes, including basic and clinical science, treatment options,...