Importance of the field: Transient receptor potential vanilloid-1 (TRPV1, vanilloid receptor-1) is a nonspecific cation channel that can be activated by multiple endogenous stimuli and by capsaicin, the active ingredient...
Importance of the field: Histamine H-3 receptor (H3R) antagonists/inverse agonists can be therapeutically useful in the treatment of various CNS, metabolic syndrome and allergic disorders, and constitute an attractive ta...
Importance of the field: Among the GPCR subclasses that have been discovered to date, 5-HT receptors are especially attractive as key biological targets with enormous clinical importance. In particular, during the last d...
Importance of the field: 17 beta-Hydroxysteroid dehydrogenases (17 beta-HSDs) mainly catalyze the reduction of C17-ketosteroids to their corresponding hydroxylated forms as well as the reverse reaction (oxidation). Able ...
Importance of the field: Anemia caused by chronic kidney disease and other chronic diseases or conditions can be managed by the treatment of biologic-based erythropoiesis stimulating agents (ESAs). Although these ESAs ar...
Background: The application is in the field of haematopoietic stem cells (HSCs) and cellular therapy. Objective: It aims at improving the outcome and rate of success of HSC transplantation for treating patients with haem...
Importance of the field: Histamine plays a key role in physiological processes through its interaction with H1-4 histamine receptors. The H-1 receptor is a key element in the pathophysiology of allergic responses. H-1 an...
Background: The application is in the field of haematopoietic stem cell (HSC) and umbilical cord blood (CB) transplantation. Objective: It aims at determining an enzymatic procedure to improve the engraftment of CB stem ...