- tRNA Binding Properties of Eukaryotic Translation Initiation Factor 2 from Encephalitozoon cuniculi
[作者：Naveau, M; Lazennec-Schurdevin, C; Panvert, M; Mechulam, Y; Schmitt, E,期刊：Biochemistry, 页码：8680-8688 , 文章类型： Article，,卷期：2010年49-40]
- A critical consequence of the initiation of translation is the setting of the reading frame for mRNA decoding. In eukaryotic and archaeal cells, heterotrimeric initiation factor e/aIF2, in its GTP form, specifically bind...
- Three-Dimensional Structures Reveal Multiple ADP/ATP Binding Modes for a Synthetic Class of Artificial Proteins
[作者：Simmons, CR; Magee, CL; Smith, DA; Lauman, L; Chaput, JC; Allen, JP,期刊：Biochemistry, 页码：8689-8699 , 文章类型： Article，,卷期：2010年49-40]
- The creation of synthetic enzymes with predefined functions represents a major challenge in future synthetic biology applications. Here, we describe six structures of de novo proteins that have been determined using prot...
- Intramolecular Heme Ligation of the Cytochrome P450 2C9 R108H Mutant Demonstrates Pronounced Conformational Flexibility of the B-C Loop Region: Implications for Substrate Binding
[作者：Roberts, AG; Cheesman, MJ; Primak, A; Bowman, MK; Atkins, WM; Rettie, AE,期刊：Biochemistry, 页码：8700-8708 , 文章类型： Article，,卷期：2010年49-40]
- A previous study [Dickmann, L., et al. (2004) Mol. Pharmacol. 65, 842-850] revealed some unusual properties of the R108H mutant of cytochrome P450 2C9 (CYP2C9), including elevated thermostability relative to that of CYP2...
- Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel
[作者：Gay, SC; Roberts, AG; Maekawa, K; Talakad, JC; Hong, WX; Zhang, QH; Stout, CD; Halpert, JR,期刊：Biochemistry, 页码：8709-8720 , 文章类型： Article，,卷期：2010年49-40]
- Prior X-ray crystal structures of rabbit cytochrome P450 2B4 (2B4) in complexes with various imidazoles have demonstrated markedly different enzyme conformations depending on the size of the inhibitor occupying the activ...
- The H187R Mutation of the Human Prion Protein Induces Conversion of Recombinant Prion Protein to the PrPSc-like Form
[作者：Hosszu, LLP; Tattum, MH; Jones, S; Trevitt, CR; Wells, MA; Waltho, JP; Collinge, J; Jackson, GS; Clarke, AR,期刊：Biochemistry, 页码：8729-8738 , 文章类型： Article，,卷期：2010年49-40]
- Prion diseases are associated with a conformational switch in the prion protein (PrP) from its normal cellular form (denoted PrPC) to a disease-associated "scrapie" form (PrPSc). A number of PrPSc-like conformations can ...
- Euphorbia Peroxidase Catalyzes Thiocyanate Oxidation in Two Different Ways, the Distal Calcium Ion Playing an Essential Role
[作者：Pintus, F; Spano, D; Bellelli, A; Angelucci, F; Scorciapino, AM; Anedda, R; Medda, R; Floris, G,期刊：Biochemistry, 页码：8739-8747 , 文章类型： Article，,卷期：2010年49-40]
- The oxidation of the pseudohalide thiocyanate (SCN-) by Euphorbia peroxidase, in the presence or absence of added calcium, is investigated. After incubation of the native enzyme with hydrogen peroxide, the formation of C...
- Molecular Details of the Yeast Frataxin-Isul Interaction during Mitochondrial Fe-S Cluster Assembly
[作者：Cook, JD; Kondapalli, KC; Rawat, S; Childs, WC; Murugesan, Y; Dancis, A; Stemmler, TL,期刊：Biochemistry, 页码：8756-8765 , 文章类型： Article，,卷期：2010年49-40]
- Frataxin, a conserved nuclear-encoded mitochondrial protein, plays a direct role in iron-sulfur cluster biosynthesis within the ISC assembly pathway. Humans with frataxin deficiency have Friedreich's ataxia, a neurodegen...
- A Biosensor Study Indicating That Entropy, Electrostatics, and Receptor Glycosylation Drive the Binding Interaction between Interleukin-7 and Its Receptor
[作者：Walsh, STR,期刊：Biochemistry, 页码：8766-8778 , 文章类型： Article，,卷期：2010年49-40]
- The interaction between interleukin-7 (IL-7) and its alpha-receptor, IL-7R alpha, plays fundamental roles in the development, survival, and homeostasis of B- and T-cells. N-Linked glycosylation of human IL-7R alpha enhan...
- Binding of beta-D-Glucosides and beta-D-Mannosides by Rice and Barley beta-D-Glycosidases with Distinct Substrate Specificities
[作者：Kuntothom, T; Raab, M; Tvaroska, I; Fort, S; Pengthaisong, S; Canada, J; Calle, L; Jimenez-Barbero, J; Cairns, JRK; Hrmova, M,期刊：Biochemistry, 页码：8779-8793 , 文章类型： Article，,卷期：2010年49-40]
- Predominantly, rice Os3BGlu7 operates as a beta-D-glucosidase (EC 3.2.1.21), while barley HvBII acts as a beta-D-mannosidase (EC 3.2.1.25). Saturation transfer difference nuclear magnetic resonance (STD NMR) and transfer...
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