- Tumor Interstitial Fluid as Modulator of Cancer Inflammation, Thrombosis, Immunity and Angiogenesis
[作者:Baronzio, G; Schwartz, L; Kiselevsky, M; Guais, A; Sanders, E; Milanesi, G; Baronzio, M; Freitas, I,期刊:Anticancer Research, 页码:405-414 , 文章类型: Review,,卷期:2012年32-2]
- Tumor interstitial fluid (TIF) is a watery phase that accumulates inside the tumor interstitium. Its genesis and fate depend on various factors, namely tumor type, metabolic state of the tumor, expression of vascular end...
- Oncogenic MST1R Activity in Pancreatic and Gastric Cancer Represents a Valid Target of HSP90 Inhibitors
[作者:Moser, C; Lang, SA; Hackl, C; Zhang, H; Lundgren, K; Hong, V; Mckenzie, A; Weber, B; Park, JS; Schlitt, HJ; Geissler, EK; Jung, YD; Stoeltzing, O,期刊:Anticancer Research, 页码:427-437 , 文章类型: Article,,卷期:2012年32-2]
- Aim: To evaluate the effects of HSP90 blockade by EC154 on the oncogenic receptor tyrosine kinase macrophage-stimulating 1 receptor (MST1R) in gastric and pancreatic cancer. Materials and Methods: Impact of EC154 on sign...
- Elevated Expression of IRS2 in the Progression from Neurofibroma to Malignant Peripheral Nerve Sheath Tumor
[作者:Shaw, CM; Grobmyer, SR; Ucar, DA; Cance, WG; Reith, JD; Hochwald, SN,期刊:Anticancer Research, 页码:439-443 , 文章类型: Article,,卷期:2012年32-2]
- Background/Aim: Novel drugs to inhibit insulin receptor substrate (IRS) and focal adhesion kinase (FAK) pathways are emerging and will be sarcoma subtype-specific. As a result, defining expression of proteins in these pa...
- Preclinical Activity of the Novel Orally Bioavailable HSP90 Inhibitor NVP-HSP990 against Multiple Myeloma Cells
[作者:Stuhmer, T; Iskandarov, K; Gao, ZH; Bumm, T; Grella, E; Jensen, MR; Einsele, H; Chatterjee, M; Bargou, RC,期刊:Anticancer Research, 页码:453-462 , 文章类型: Article,,卷期:2012年32-2]
- Background: HSP90 inhibitors effectively reduce expression and activity levels of oncogenic survival proteins. However, their clinical anti-multiple myeloma (MM) activity has been found to be rather weak, spurring the ex...
- The Dual Kinase Inhibitor NVP-BEZ235 in Combination with Cytotoxic Drugs Exerts Anti-proliferative Activity towards Acute Lymphoblastic Leukemia Cells
[作者:Schult, C; Dahlhaus, M; Glass, A; Fischer, K; Lange, S; Freund, M; Junghanss, C,期刊:Anticancer Research, 页码:463-474 , 文章类型: Article,,卷期:2012年32-2]
- Background: Inhibition of signal transduction pathways has been successfully introduced into cancer treatment. The dual phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235 h...
- Evaluation of Breast Cancer Susceptibility Loci on 2q35, 3p24, 17q23 and FGFR2 Genes in Taiwanese Women with Breast Cancer
[作者:Lin, CY; Ho, CM; Bau, DT; Yang, SF; Liu, SH; Lin, PH; Lin, TH; Tien, N; Shih, MC; Lu, JJ,期刊:Anticancer Research, 页码:475-482 , 文章类型: Article,,卷期:2012年32-2]
- Aim: Breast cancer is the most common cancer in women. In recent years, mounting evidence has identified the possibility that 2q35, 3p24, 17q23 and fibroblast growth factor receptor 2 (FGFR2) may be genetic susceptibilit...
- C-reactive Protein is a Potential Prognostic Factor for Metastatic Gastric Cancer
[作者:Shimura, T; Kitagawa, M; Yamada, T; Ebi, M; Mizoshita, T; Tanida, S; Kataoka, H; Kamiya, T; Joh, T,期刊:Anticancer Research, 页码:491-496 , 文章类型: Article,,卷期:2012年32-2]
- Background/Aim: C-reactive protein (CRP) has been associated with the development of many carcinomas, but the significance of CRP remains unclear for metastatic gastric cancer (MGC). Patients and Methods: Sixty one patie...
- Involvement of MAP Kinases in the Cytotoxicity of Acyclic Nucleoside Phosphonates
[作者:Mertlikova-Kaiserova, H; Nejedla, M; Holy, A; Votruba, I,期刊:Anticancer Research, 页码:497-501 , 文章类型: Article,,卷期:2012年32-2]
- Background: 9[2-(phosphonomethoxy)ethyl] guanine (PMEG) is a nucleotide analogue with anticancer activity. Here we investigate the role of ERK, p38, INK and AKT kinases in PMEG-induced apoptosis. Materials and Methods: C...
- Expression Profiles of Signal Transduction Genes in Ex Vivo Drug-resistant Pediatric Acute Lymphoblastic Leukemia
[作者:Szczepanek, J; Pogorzala, M; Jarzab, M; Oczko-Wojciechowska, M; Kowalska, M; Tretyn, A; Wysocki, M; Jarzab, B; Styczynski, J,期刊:Anticancer Research, 页码:503-506 , 文章类型: Article,,卷期:2012年32-2]
- Aim: Identification of signal transduction genes related to drug resistance in pediatric acute lymphoblastic leukemia (ALL). Materials and Methods: Ex vivo drug resistance in 107 children, divided into study and validati...
- Putative Supramolecular Complexes Formed by Carotenoids and Xanthophylls with Ascorbic Acid to Reverse Multidrug Resistance in Cancer Cells
[作者:Molnar, J; Serly, J; Pusztai, R; Vincze, I; Molnar, P; Horvath, G; Deli, J; Maoka, T; Zalatnai, A; Tokuda, H; Nishino, H,期刊:Anticancer Research, 页码:507-517 , 文章类型: Article,,卷期:2012年32-2]
- Background: The molecular basis of interaction of selected carotenoids and xanthophylls with ascorbic acid on cancer cells was studied to determine their anticancer effects. Materials and Methods: Drug accumulation was m...
- Cytotoxicity of Hydrophylic Silver Carboxylato Complexes
[作者:Fourie, E; Erasmus, E; Swarts, JC; Tuchscherer, A; Jakob, A; Lang, H; Joone, GK; Van Rensburg, CEJ,期刊:Anticancer Research, 页码:519-522 , 文章类型: Article,,卷期:2012年32-2]
- Background: Gold(I) and platinum(II) d(10) and d(8) electronic complexes such as (Au(PPh2CH2CH2PPh2)(2))Cl and cisplatin, ((H3N)(2)PtCl2), possess strong antineoplastic activities. Almost no information is available rega...
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