- Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation
[作者：Wang, JB; Erickson, JW; Fuji, R; Ramachandran, S; Gao, P; Dinavahi, R; Wilson, KF; Ambrosio, ALB; Dias, SMG; Dang, CV; Cerione, RA,期刊：Cancer Cell, 页码：207-219 , 文章类型： Article，,卷期：2010年18-3]
- Rho GTPases impact a number of activities important for oncogenesis. We describe a small molecule inhibitor that blocks oncogenic transformation induced by various Rho GTPases in fibroblasts, and the growth of human brea...
- A High-Frequency Regulatory Polymorphism in the p53 Pathway Accelerates Tumor Development
[作者：Post, SM; Quintas-Cardama, A; Pant, V; Iwakuma, T; Hamir, A; Jackson, JG; Maccio, DR; Bond, GL; Johnson, DG; Levine, AJ; Lozano, G,期刊：Cancer Cell, 页码：220-230 , 文章类型： Article，,卷期：2010年18-3]
- MDM2, a negative regulator of p53, is elevated in many cancers that retain wild-type p53. A single nucleotide polymorphism (SNP) in the human MDM2 promoter increases the affinity of Sp1 resulting in elevated MDM2 levels....
- An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction
[作者：Macias, E; Jin, AW; Deisenroth, C; Bhat, K; Mao, H; Lindstrom, MS; Zhang, YP,期刊：Cancer Cell, 页码：231-243 , 文章类型： Article，,卷期：2010年18-3]
- In vitro studies have shown that inhibition of ribosomal biogenesis can activate p53 through ribosomal protein (RP)-mediated suppression of Mdm2 E3 ligase activity. To study the physiological significance of the RP-Mdm2 ...
- In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma
[作者：Mir, SE; Hamer, PCD; Krawczyk, PM; Balaj, L; Claes, A; Niers, JM; Van Tilborg, AAG; Zwinderman, AH; Geerts, D; Kaspers, GJL; Vandertop, WP; Cloos, J; Tannous, BA; Wesseling, P; Aten, JA; Noske, DP; Van Noorden, CJF; Wurdinger, T,期刊：Cancer Cell, 页码：244-257 , 文章类型： Article，,卷期：2010年18-3]
- Kinases execute pivotal cellular functions and are therefore widely investigated as potential targets in anticancer treatment. Here we analyze the kinase gene expression profiles of various tumor types and reveal the wee...
- Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein
[作者：Yang, QK; Deng, XM; Lu, BW; Cameron, M; Fearns, C; Patricelli, MP; Yates, JR; Gray, NS; Lee, JD,期刊：Cancer Cell, 页码：258-267 , 文章类型： Article，,卷期：2010年18-3]
- BMK1 is activated by mitogens and oncogenic signals and, thus, is strongly implicated in tumorigenesis. We found that BMK1 interacted with promyelocytic leukemia protein (PML), and inhibited its tumor-suppressor function...
- The Notch/Hes1 Pathway Sustains NF-kappa B Activation through CYLD Repression in T Cell Leukemia
[作者：Espinosa, L; Cathelin, S; D'Altri, T; Trimarchi, T; Statnikov, A; Guiu, J; Rodilla, V; Ingles-Esteve, J; Nomdedeu, J; Bellosillo, B; Besses, C; Abdel-Wahab, O; Kucine, N; Sun, SC; Song, GC; Mullighan, CC; Levine, RL; Rajewsky, K; Aifantis, I; Bigas, A,期刊：Cancer Cell, 页码：268-281 , 文章类型： Article，,卷期：2010年18-3]
- It was previously shown that the NF-kappa B pathway is downstream of oncogenic Notch1 in T cell acute lymphoblastic leukemia (T-ALL). Here, we visualize Notch-induced NF-kappa B activation using both human T-ALL cell lin...
- Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21
[作者：Hatley, ME; Patrick, DM; Garcia, MR; Richardson, JA; Bassel-Duby, R; van Rooij, E; Olson, EN,期刊：Cancer Cell, 页码：282-293 , 文章类型： Article，,卷期：2010年18-3]
- Lung cancer is the leading cause of cancer-related deaths in the world, and non-small-cell lung cancer (NSCLC) accounts for 80% of cases. MicroRNA-21 (miR-21) expression is increased and predicts poor survival in NSCLC. ...
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