- Synthesis and activity of tetrapeptidic HTLV-I protease inhibitors possessing different P3-cap moieties.
[作者:Zhang, Meihui;Nguyen, Jeffrey-Tri;Kumada, Henri-Obadja;Kimura, Tooru;Cheng, Maosheng;Hayashi, Yoshio;Kiso, Yoshiaki;,期刊:Bioorganic & Medicinal Chemistry, 页码:5795-5802 , 文章类型: 研究论文,,卷期:2008年16-10]
- The causative agent behind adult T-cell leukemia and tropical spastic paraparesis/HTLV-I-assocd. myelopathy is the human T-cell leukemia virus type 1 (HTLV-I). Tetrapeptidic HTLV-I protease inhibitors were designed on a...
- New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino) -2H-1-benzopyrans structurally related to (?-cromakalim as tissue-selective pancreatic b-cell KATP channel openers.
[作者:Sebille, Sophie;de Tullio, Pascal;Florence, Xavier;Becker, Benedicte;Antoine, Marie-Helene;Michaux, Catherine;Wouters, Johan;Pirotte, Bernard;Lebrun, Philippe;,期刊:Bioorganic & Medicinal Chemistry, 页码:5704-5719 , 文章类型: 研究论文,,卷期:2008年16-10]
- The present work was aimed at exploring a series of -2H-1-benzopyrans structurally related to (?-cromakalim and differently substituted at the 4- and 6-positions. The biol. effects of these putative activators of ATP-se...
- SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease.
[作者:Leone, Samantha;Mutti, Cesare;Kazantsev, Aleksey;Sturlese, Mattia;Moro, Stefano;Cattaneo, Elena;Rigamonti, Dorotea;Contini, Alessandro;,期刊:Bioorganic & Medicinal Chemistry, 页码:5695-5703 , 文章类型: 研究论文,,卷期:2008年16-10]
- REST/NRSF is a multifunctional transcription factor that represses or silences many neuron-specific genes in both neural and non-neural cells by recruitment to its cognate RE1/NRSE regulatory sites. An increase in RE1/N...
- The pyridoxamine action on Amadori compounds: A reexamination of its scavenging capacity and chelating effect.
[作者:Adrover, Miquel;Vilanova, Bartolome;Frau, Juan;Munoz, Francisco;Donoso, Josefa;,期刊:Bioorganic & Medicinal Chemistry, 页码:5557-5569 , 文章类型: 研究论文,,卷期:2008年16-10]
- glycation end products (AGEs) by non-enzymic protein glycation, which are involved in ensuing protein damage. Pyridoxamine is a potent drug against protein glycation, and can act on several pathways in the glycation pro...
- Synthesis of 5'-functionalized nucleosides: S-Adenosylhomocysteine analogs with the carbon-5' and sulfur atoms replaced by a vinyl or halovinyl unit.
[作者:Wnuk, Stanislaw F.;Sacasa, Pablo R.;Lewandowska, Elzbieta;Andrei, Daniela;Cai, Sumin;Borchardt, Ronald T.;,期刊:Bioorganic & Medicinal Chemistry, 页码:5424-5433 , 文章类型: 研究论文,,卷期:2008年16-10]
- Adenosine and uridine analogs functionalized with alkenyl or fluoroalkenyl chain at C5' were prepd. employing cross-metathesis, Negishi couplings, and Wittig reactions. Metathesis of the protected 5'-deoxy-5'-methylenea...
- Synthesis of indirubin-N'-glycosides and their anti-proliferative activity against human cancer cell lines.
[作者:Libnow, Stefanie;Methling, Karen;Hein, Martin;Michalik, Dirk;Harms, Manuela;Wende, Kristian;Flemming, Anke;Koeckerling, Martin;Reinke, Helmut;Bednarski, Patrick J.;Lalk, Michael;Langer, Peter;,期刊:Bioorganic & Medicinal Chemistry, 页码:5570-5583 , 文章类型: 研究论文,,卷期:2008年16-10]
- The first indirubin-N'-glycosides were prepd. based on reactions of isatin-N'-glycosides with indoxyl derivs. The products show a significant anti-proliferative activity against various human cancer cell lines. Good re...
- Synthesis and DNA cleaving activity of water-soluble non-conjugated thienyl tetraynes.
[作者:Torikai, Kohei;Otsuka, Yoichi;Nishimura, Makoto;Sumida, Megumi;Kawai, Tomoji;Sekiguchi, Kiyotoshi;Ueda, Ikuo;,期刊:Bioorganic & Medicinal Chemistry, 页码:5441-5451 , 文章类型: 研究论文,,卷期:2008年16-10]
- (Heterocyclic Compounds (One Hetero Atom)) Section Four water-sol. non-conjugated thienyl tetraynes were synthesized and their DNA cleaving activity was evaluated using electrophoresis, at. force microscopy (AFM), and Es...
- Prediction of the aqueous solvation free energy of organic compounds by using autocorrelation of molecular electrostatic potential surface properties combined with response surface analysis.
[作者:Michielan, Lisa;Bacilieri, Magdalena;Kaseda, Chosei;Moro, Stefano;,期刊:Bioorganic & Medicinal Chemistry, 页码:5733-5742 , 文章类型: 研究论文,,卷期:2008年16-10]
- Several quant. structure-property relationship (QSPR) approaches have been explored for the prediction of aq. soly. or aq. solvation free energies, DG sol, as crucial parameter affecting the pharmacokinetic profile and t...
- Synthesis and in vitro PDT activity of miscellaneous porphyrins with amino acid and uracil.
[作者:Shi, Weimin;Zhang, Gen;Dai, Guifu;Zhang, Yunxiao;Zhao, Jin;Tao, Jingchao;,期刊:Bioorganic & Medicinal Chemistry, 页码:5665-5671 , 文章类型: 研究论文,,卷期:2008年16-10]
- The synthesis of a series of modularized porphyrins bearing bioactive mol. is described. Starting with meso-tetraphenylporphyrin, the compds. with two nitro functional groups were synthesized via regiospecific nitration...
- Thermodynamics and fluorescence studies of the interactions of cyclooctapeptides with Hg2+, Pb2+, and Cd2+.
[作者:Ngu-Schwemlein, Maria;Gilbert, Willie;Askew, Kshawna;Schwemlein, Stefanie;,期刊:Bioorganic & Medicinal Chemistry, 页码:5778-5787 , 文章类型: 研究论文,,卷期:2008年16-10]
- The purpose of this work is to characterize the interactions of cyclooctapeptides (CP) contg. glutamyl and/or cysteinyl residues with common heavy-metal ions in order to facilitate the design of cyclopeptides as sensors ...
- Sensitization to p-amino aromatic compounds: Study of the covalent binding of 2,5-dimethyl-p-benzoquinonediimine to a model peptide by electrospray ionization tandem mass spectrometry.
[作者:Eilstein, Joan;Gimenez-Arnau, Elena;Duche, Daniel;Cavusoglu, Nuekhet;Hussler, Georges;Rousset, Francoise;Lepoittevin, Jean-Pierre;,期刊:Bioorganic & Medicinal Chemistry, 页码:5482-5489 , 文章类型: 研究论文,,卷期:2008年16-10]
- To understand the hapten-protein complex formation in the context of skin contact allergy to p-amino arom. derivs., 2,5-dimethyl-p-benzoquinonediimine was used as a model compd. to study the reactivity of p-benzoquinoned...
- Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.
[作者:Saitoh, Takeki;Kuramochi, Kouji;Imai, Takahiko;Takata, Kei-ichi;Takehara, Masahide;Kobayashi, Susumu;Sakaguchi, Kengo;Sugawara, Fumio;,期刊:Bioorganic & Medicinal Chemistry, 页码:5815-5825 , 文章类型: 研究论文,,卷期:2008年16-10]
- Podophyllotoxin (PT), a strong cytotoxic agent from berberidaceae, has been known to inhibit tubulin polymn. Although PT has been used for developing anticancer drugs as one of seed compds., clin. treatment by itself ha...
- Peptomeric analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds.
[作者:Legowska, Anna;Bulak, Elzbieta;Wysocka, Magdalena;Jaskiewicz, Anna;Lesner, Adam;Debowski, Dawid;Rolka, Krzysztof;,期刊:Bioorganic & Medicinal Chemistry, 页码:5644-5652 , 文章类型: 研究论文,,卷期:2008年16-10]
- A series of linear and monocyclic analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds, modified by N-(4-aminobutyl)glycine (Nlys) and N-benzylglycine (Nphe), were obtained by the solid-phase method. Some o...
- Petiolins A-C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum.
[作者:Tanaka, Naonobu;Kubota, Takaaki;Ishiyama, Haruaki;Araki, Atsushi;Kashiwada, Yoshiki;Takaishi, Yoshihisa;Mikami, Yuzuru;Kobayashi, Jun'ichi;,期刊:Bioorganic & Medicinal Chemistry, 页码:5619-5623 , 文章类型: 研究论文,,卷期:2008年16-10]
- Two new phloroglucinol derivs. possessing chromane skeleton, petiolins A (1) and B (2), and a new phloroglucinol deriv. contg. a dihydrofuran ring, petiolin C (3), were isolated from aerial parts of Hypericum pseudopetio...
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