- Experimental Test of the Thermodynamic Model of Protein Cooperativity Using Temperature-Induced Unfolding of a Ubq-UIM Fusion Protein
[作者：Patel, MM; Sgourakis, NG; Garcia, AE; Makhatadze, GI,期刊：Biochemistry, 页码：8455-8467 , 文章类型： Article，,卷期：2010年49-39]
- This study describes the thermodynamic characterization of a Ubq-UIM fusion construct (Ubq-UIM), designed from the ubiquitin UIM interaction system, to determine whether it exhibits cooperativity of folding. The Ubq-UIM ...
- NMR Characterization of Copper-Binding Domains 4-6 of ATP7B
[作者：Fatemi, N; Korzhnev, DM; Velyvis, A; Sarkar, B; Forman-Kay, JD,期刊：Biochemistry, 页码：8468-8477 , 文章类型： Article，,卷期：2010年49-39]
- The Wilson disease protein (ATP7B) is a copper-transporting member of the P-type ATPase superfamily, which. plays a central role in copper homeostasis and interacts with the copper chaperone Atox1. The N-terminus of ATP7...
- Regulation of Human Carbonyl Reductase 3 (CBR3; SDR21C2) Expression by Nrf2 in Cultured Cancer Cells
[作者：Ebert, B; Kisiela, M; Malatkova, P; El-Hawari, Y; Maser, E,期刊：Biochemistry, 页码：8499-8511 , 文章类型： Article，,卷期：2010年49-39]
- Carbonyl reduction is a central metabolic process that controls the level of key regulatory molecules as well as xenobiotics. Carbonyl reductase 3 (CBR3; SDR21C2), a member of the short-chain dehydro-genase/reductase (SD...
- Steady-State Kinetic and Inhibition Studies of the Mammalian Target of Rapamycin (mTOR) Kinase Domain and mTOR Complexes
[作者：Tao, ZH; Barker, J; Shi, SDH; Gehring, M; Sun, SX,期刊：Biochemistry, 页码：8488-8498 , 文章类型： Article，,卷期：2010年49-39]
- The mammalian target of rapamycin (mTOR) is a Ser/Thr protein kinase and a major controller of cell growth. In cells, mTOR forms two distinct multiprotein complexes, mTORC1 and mTORC2. The mTORC1 complex can phosphorylat...
- Synergistic and Inhibitory Effects of Aminopeptidase Peptides on Bacillus thuringiensis Cry11Ba Toxicity in the Mosquito Anopheles gambiae
[作者：Zhang, R; Hua, G; Urbauer, JL; Adang, MJ,期刊：Biochemistry, 页码：8512-8519 , 文章类型： Article，,卷期：2010年49-39]
- Cry11Ba produced by Bacillus thuringiensis subsp. jegathesan is an active toxin for larvae of the mosquito Anopheles gambiae. A 106-kDa aminopeptidase N (APN), called AgAPN2, was previously identified as a Cry11Ba recept...
- Contribution of Amino Acid Region 659-663 of Factor Va Heavy Chain to the Activity of Factor Xa within Prothrombinase
[作者：Hirbawi, J; Vaughn, JL; Bukys, MA; Vos, HL; Kalafatis, M,期刊：Biochemistry, 页码：8520-8534 , 文章类型： Article，,卷期：2010年49-39]
- Factor Va, the cofactor of prothrombinase, is composed of heavy and light chains associated noncovalently in the presence of divalent metal ions. The COOH-terminal region of the heavy chain contains acidic amino acid clu...
- Conformational Changes and Substrate Recognition in Pseudomonas aeruginosa D-Arginine Dehydrogenase
[作者：Fu, GX; Yuan, HL; Li, CR; Lu, CD; Gadda, G; Weber, IT,期刊：Biochemistry, 页码：8535-8545 , 文章类型： Article，,卷期：2010年49-39]
- DADH catalyzes the flavin-dependent oxidative deamination oft-amino acids to the corresponding alpha-keto acids and ammonia. Here we report the first X-ray crystal structures of DADH at 1.06 angstrom resolution and its c...
- Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP and dGMP To Be Inserted opposite Guanidinohydantoin
[作者：Beckman, J; Wang, MN; Blaha, G; Wang, JM; Konigsberg, WH,期刊：Biochemistry, 页码：8554-8563 , 文章类型： Article，,卷期：2010年49-39]
- Continuous oxidative damage inflicted on DNA produces 7,8-dihydro-8-oxoguanine (8-oxoG), a commonly occurring lesion that can potentially cause cancer by producing G -> T transversions during DNA replication. Mild oxidat...
- Topology of Transmembrane Channel-like Gene 1 Protein
[作者：Labay, V; Weichert, RM; Makishima, T; Griffith, AJ,期刊：Biochemistry, 页码：8592-8598 , 文章类型： Article，,卷期：2010年49-39]
- Mutations of transmembrane channel-like gene 1 (TMC1) cause hearing loss in humans and mice. TMC1 is the founding member of a family of genes encoding proteins of unknown function that are predicted to contain multiple t...
- Peptide-Binding Sites As Revealed by the Crystal Structures of the Human Hsp40 Hdj1 C-Terminal Domain in Complex with the Octapeptide from Human Hsp70
[作者：Suzuki, H; Noguchi, S; Arakawa, H; Tokida, T; Hashimoto, M; Satow, Y,期刊：Biochemistry, 页码：8577-8584 , 文章类型： Article，,卷期：2010年49-39]
Heat shock protein (Hsp) 40s play essential roles in cellular processes by cooperating with Hsp70 proteins. Hsp40 proteins recognize non-native polypeptides, deliver these peptides to Hsp70 proteins, and stimulate the...
- Structural and Functional Characterization of the Recombinant Human Mitochondrial Trifunctional Protein
[作者：Fould, B; Garlatti, V; Neumann, E; Fenel, D; Gaboriaud, C; Arlaud, GJ,期刊：Biochemistry, 页码：8608-8617 , 文章类型： Article，,卷期：2010年49-39]
- The alpha and beta subunits of the human mitochondrial trifunctional protein (TFP), the multienzyme complex involved in fatty acid beta-oxidation, were coexpressed in Escherichia coli and purified to homogeneity by nicke...
|