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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Secondary Structure and Solvent Accessibility of a Calmodulin-Binding C-Terminal Segment of Membrane-Associated Myelin Basic Protein [作者：Homchaudhuri, L; De Avila, M; Nilsson, SB; Bessonov, K; Smith, GST; Bamm, VV; Musse, AA; Harauz, G; Boggs, JM,期刊：Biochemistry, 页码：8955-8966 , 文章类型： Article，,卷期：2010年49-41] Myelin basic protein (MBP), specifically the 18.5 k Da isoform, is a peripheral membrane protein and a major component of mammalian central nervous system myelin. It is an intrinsically disordered and multifunctional pro... Mutations Alter the Geometry and Mechanical Properties of Alzheimer's A beta(1-40) Amyloid Fibrils [作者：Paparcone, R; Pires, MA; Buehler, MJ,期刊：Biochemistry, 页码：8967-8977 , 文章类型： Article，,卷期：2010年49-41] The identification of more efficient therapies for defeating severe degenerative diseases like Alzheimer's is a major goal of drug discovery research. Realizing this ambitious goal will likely require a series of molecul... NMR Solution Structures of Clustered Abasic Site Lesions in DNA: Structural Differences between 3 '-Staggered (-3) and 5 '-Staggered (+3) Bistranded Lesions [作者：Hazel, RD; de los Santos, C,期刊：Biochemistry, 页码：8978-8987 , 文章类型： Article，,卷期：2010年49-41] Ionizing radiation produces a distinctive pattern of bistranded clustered lesions in DNA. A relatively low number of clustered lesions may be lethal to cells when compared to a larger number of single lesions. Enzyme cle... NmerA of Tn501 Mercuric Ion Reductase: Structural Modulation of the pK(a) Values of the Metal Binding Cysteine Thiols [作者：Ledwidge, R; Hong, B; Dotsch, V; Miller, SM,期刊：Biochemistry, 页码：8988-8998 , 文章类型： Article，,卷期：2010年49-41] To avoid nonspecific and/or undesirable binding and reactivity of metal ions with cellular components, organisms have evolved metal-specific systems for trafficking proteins. Although systems differ, those handling soft ... Structure and Mechanism of the 6-Oxopurine Nucleosidase from Trypanosoma brucei brucei [作者：Vandemeulebroucke, A; Minici, C; Bruno, I; Muzzolini, L; Tornaghi, P; Parkin, DW; Versees, W; Steyaert, J; Degano, M,期刊：Biochemistry, 页码：8999-9010 , 文章类型： Article，,卷期：2010年49-41] Trypanosomes are purine-auxotrophic parasites that depend upon nucleoside hydrolase (NH) activity to salvage nitrogenous bases necessary for nucleic acid and cofactor synthesis. Nonspecific and purine-specific NHs have b... Improved Cytochrome P450 3A4 Molecular Models Accurately Predict the Phe215 Requirement for Raloxifene Dehydrogenation Selectivity [作者：Moore, CD; Shahrokh, K; Sontum, SF; Cheatham, TE; Yost, GS,期刊：Biochemistry, 页码：9011-9019 , 文章类型： Article，,卷期：2010年49-41] The use of molecular modeling in conjunction with site-directed mutagenesis has been extensively used to study substrate orientation within cytochrome P450 active sites and to identify potential residues involved in the ... MbtH-Like Proteins as Integral Components of Bacterial Nonribosomal Peptide Synthetases [作者：Felnagle, EA; Barkei, JJ; Park, H; Podevels, AM; McMahon, MD; Drott, DW; Thomas, MG,期刊：Biochemistry, 页码：8815-8817 , 文章类型： Article，,卷期：2010年49-41] The biosynthesis of many natural products of clinical interest involves large, multidomain enzymes called nonribosomal peptide synthetases (NRPSs). In bacteria, many of the gene clusters coding for NRPSs also code for a ... Activation of DNA Cleavage by Oligomerization of DNA-Bound SgrAI [作者：Park, CK; Stiteler, AP; Shah, S; Ghare, MI; Bitinaite, J; Horton, NC,期刊：Biochemistry, 页码：8818-8830 , 文章类型： Article，,卷期：2010年49-41] SgrAI is a type II restriction endonuclease that cuts an unusually long recognition sequence and exhibits allosteric self-modulation of DNA activity and sequence specificity. Precleaved primary site DNA has been shown to... Kinetic Studies of the Interaction of beta-Lactoglobulin with Model Membranes: Stopped-Flow CD and Fluorescence Studies [作者：Ge, N; Zhang, XQ; Keiderling, TA,期刊：Biochemistry, 页码：8831-8838 , 文章类型： Article，,卷期：2010年49-41] beta-Lactoglobulin (PLG) is a member of the lipocalin protein family and has been shown to undergo changes in structure upon interaction with various surfactants and lipid vesicles. Dynamic light scattering (DLS) and Fou... Contribution of Subdomain Structure to the Thermal Stability of the Cholera Toxin Al Subunit [作者：Banerjee, T; Pande, A; Jobling, MG; Taylor, M; Massey, S; Holmes, RK; Tatulian, SA; Teter, K,期刊：Biochemistry, 页码：8839-8846 , 文章类型： Article，,卷期：2010年49-41] The catalytic Al subunit of cholera toxin (CTAl) is an ADP-ribosyltransferase with three distinct subdomains: CTAl1 forms the catalytic core of the toxin, CTAl, is an extended linker between CTAl1 and CTAl3, and CTAl3 is... Transmembrane Helix I and Periplasmic Loop 1 of Escherichia coli ProP Are Involved in Osmosensing and Osmoprotectant Transport [作者：Keates, RAB; Culham, DE; Vernikovska, YI; Zuiani, AJ; Boggs, JM; Wood, JM,期刊：Biochemistry, 页码：8847-8856 , 文章类型： Article，,卷期：2010年49-41] Osmoregulatory transporters stimulate bacterial growth by mediating osmoprotectant uptake in response to increasing osmotic pressure. The ProP protein of Escherichia coli transports proline and other osmoprotectants. Lik... Unprecedented Peroxidase-like Activity of Rhodnius prolixus Nitrophorin 2: Identification of the [Fe-IV=O Por(center dot)](+) and [Fe-IV=O Por](Tyr38(center dot)) Intermediates and Their Role(s) in Substrate Oxidation [作者：Singh, R; Berry, RE; Yang, F; Zhang, HJ; Walker, FA; Ivancich, A,期刊：Biochemistry, 页码：8857-8872 , 文章类型： Article，,卷期：2010年49-41] We have identified a novel enzymatic reaction for nitrophorin 2 (NP2), a heme protein previously characterized as a nitric oxide carrier in the saliva of the Rhodnius prolixus insect. NP2 exhibited levels of peroxidase a... The Oxygen-Tolerant Hydrogenase I from Aquifex aeolicus Weakly Interacts with Carbon Monoxide: An Electrochemical and Time-Resolved FTIR Study [作者：Pandelia, ME; Infossi, P; Giudici-Orticoni, MT; Lubitz, W,期刊：Biochemistry, 页码：8873-8881 , 文章类型： Article，,卷期：2010年49-41] The [NiFe] hydrogenase (Hase I) involved in the aerobic respiration of the hyperthermophilic bacterium Aquifex aeolicus shows increased oxygen tolerance and thermostability and can form very stable films on pyrolytic gra... Key Dynamics of Conserved Asparagine in a Cryptochrome/Photolyase Family Protein by Fourier Transform Infrared Spectroscopy [作者：Iwata, T; Zhang, Y; Hitomi, K; Getzoff, ED; Kandori, H,期刊：Biochemistry, 页码：8882-8891 , 文章类型： Article，,卷期：2010年49-41] Cryptochromes (Crys) and photolyases (Phrs) are flavoproteins that contain an identical cofactor (flavin adenine dinucleotide, FAD) within the same protein architecture but whose physiological functions are entirely diff... Use of Recombinant Cell-Permeable Small Peptides To Modulate Glucocorticoid Sensitivity of Acute Lymphoblastic Leukemia Cells [作者：Geng, CD; Vedeckis, WV,期刊：Biochemistry, 页码：8892-8901 , 文章类型： Article，,卷期：2010年49-41] Glucocorticoid (GC) hormones induce apoptosis in T-cell and pre-B-cell acute lymphoblastic leukemia (ALL) cells. Steroid-mediated apoptosis requires a threshold level of the glucocorticoid receptor (GR) protein, and incr... Global Fit Analysis of Glucose Binding Curves Reveals a Minimal Model for Kinetic Cooperativity in Human Glucokinase [作者：Larion, M; Miller, BG,期刊：Biochemistry, 页码：8902-8911 , 文章类型： Article，,卷期：2010年49-41] Human pancreatic glucokinase is a monomeric enzyme that displays kinetic cooperativity, a feature that facilitates enzyme-mediated regulation of blood glucose levels in the body. Two theoretical models have been proposed...