- N-Terminal Domain of Bombyx mori Fibroin Mediates the Assembly of Silk in Response to pH Decrease
[作者:He, YX; Zhang, NN; Li, WF; Jia, N; Chen, BY; Zhou, K; Zhang, JH; Chen, YX; Zhou, CZ,期刊:Journal of Molecular Biology, 页码:197-207 , 文章类型: Article,,卷期:2012年418-40972]
- Fibroins serve as the major building blocks of silk fiber. As the major component of fibroin, the fibroin heavy chain is a considerably large protein comprising N-terminal and C-terminal hydrophilic domains and 12 highly...
- Identification of a Region in the N-Terminus of Escherichia coli Lon That Affects ATPase, Substrate Translocation and Proteolytic Activity
[作者:Cheng, I; Mikita, N; Fishovitz, J; Frase, H; Wintrode, P; Lee, I,期刊:Journal of Molecular Biology, 页码:208-225 , 文章类型: Article,,卷期:2012年418-40972]
- Lon, also known as protease La, is an AAA+ protease machine that contains the ATPase and proteolytic domain within each enzyme subunit. Three truncated Escherichia coli Lon (ELon) mutants were generated based on a previo...
- Small-Angle X-ray Scattering and Single-Molecule FRET Spectroscopy Produce Highly Divergent Views of the Low-Denaturant Unfolded State
[作者:Yoo, TY; Meisburger, SP; Hinshaw, J; Pollack, L; Haran, G; Sosnick, TR; Plaxco, K,期刊:Journal of Molecular Biology, 页码:226-236 , 文章类型: Article,,卷期:2012年418-40972]
- The results of more than a dozen single-molecule Forster resonance energy transfer (smFRET) experiments suggest that chemically unfolded polypeptides invariably collapse from an expanded random coil to more compact dimen...
- Solution Structure of TT30, a Novel Complement Therapeutic Agent, Provides Insight into Its Joint Binding to Complement C3b and C3d
[作者:Li, KY; Gor, J; Holers, VM; Storek, MJ; Perkins, SJ,期刊:Journal of Molecular Biology, 页码:248-263 , 文章类型: Article,,卷期:2012年418-40972]
- A novel therapeutic reagent TT30 was designed to be effective in diseases of the alternative pathway of complement such as paroxysmal nocturnal hemoglobinuria and other diseases. TT30 is constructed from the first four s...
- Rotations of the 2B Sub-Domain of E. coli UvrD Helicase/Translocase Coupled to Nucleotide and DNA Binding (vol 411, pg 633, 2011)
[作者:Jia, HF; Korolev, S; Niedziela-Majka, A; Maluf, NK; Gauss, GH; Myong, S; Ha, T; Waksman, G; Lohman, TM,期刊:Journal of Molecular Biology, 页码:264-265 , 文章类型: Correction,,卷期:2012年418-40972]
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- Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody
[作者:Matsumoto, ML; Dong, KC; Yu, C; Phu, L; Gao, XX; Hannoush, RN; Hymowitz, SG; Kirkpatrick, DS; Dixit, VM; Kelley, RF,期刊:Journal of Molecular Biology, 页码:134-144 , 文章类型: Article,,卷期:2012年418-40972]
- Polyubiquitination is an essential posttranslational modification that plays critical roles in cellular signaling. PolyUb (polyubiquitin) chains are formed by linking the carboxyl-terminus of one Ub (ubiquitin) subunit t...
- Cryo-EM Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6 and Implications for Ribosome Evolution
[作者:Greber, BJ; Boehringer, D; Godinic-Mikulcic, V; Crnkovic, A; Ibba, M; Weygand-Durasevic, I; Ban, N,期刊:Journal of Molecular Biology, 页码:145-160 , 文章类型: Article,,卷期:2012年418-40972]
- Translation of mRNA into proteins by the ribosome is universally conserved in all cellular life. The composition and complexity of the translation machinery differ markedly between the three domains of life. Organisms fr...
- Catalytic Versatility and Backups in Enzyme Active Sites: The Case of Serum Paraoxonase 1
[作者:Ben-David, M; Elias, M; Filippi, JJ; Dunach, E; Silman, I; Sussman, JL; Tawfik, DS,期刊:Journal of Molecular Biology, 页码:181-196 , 文章类型: Article,,卷期:2012年418-40972]
- The origins of enzyme specificity are well established. However, the molecular details underlying the ability of a single active site to promiscuously bind different substrates and catalyze different reactions remain lar...
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