- A phase 1 study of imatinib for corticosteroid-dependent/refractory chronic graft-versus-host disease: response does not correlate with anti-PDGFRA antibodies
[作者:Chen, GL; Arai, S; Flowers, MED; Otani, JM; Qiu, JX; Cheng, EC; McMillan, A; Johnston, LJ; Shizuru, JA; Miklos, DB,期刊:Blood, 页码:4070-4078 , 文章类型: Article,,卷期:2011年118-15]
- Stimulatory antiplatelet derived growth factor receptor alpha(PDGFRA) antibodies have been associated with extensive chronic graft-versus-host disease (cGVHD). We performed a phase 1 dose escalation trial of imatinib in ...
- An open-label, pilot study of fludarabine, cyclophosphamide, and alemtuzumab in relapsed/refractory patients with B-cell chronic lymphocytic leukemia
[作者:Montillo, M; Tedeschi, A; Petrizzi, VB; Ricci, F; Crugnola, M; Spriano, M; Spedini, P; Ilariucci, F; Uziel, L; Attolico, I; Vismara, E; De Blasio, A; Zaccaria, A; Morra, E,期刊:Blood, 页码:4079-4085 , 文章类型: Article,,卷期:2011年118-15]
- Although combination regimens have improved outcomes over monotherapy in chronic lymphocytic leukemia (CLL), patients eventually relapse. Combined fludarabine, cyclophosphamide, and monoclonal anti-CD52 antibody alemtuzu...
- SEVENTH REPORT OF THE JOINT NATIONAL COMMITTEE ON PREVENTION, DETECTION, EVALUATION, AND TREATMENT OF HIGH BLOOD PRESSURE
[作者:Chobanian, AV; Bakris, GL; Black, HR; Cushman, WC; Green, LA; Izzo, JL; Jones, DW; Materson, BJ; Oparil, S; Wright, JT; Roccella, EJ,期刊:Blood, 页码:1206-1252 , 文章类型: Article,,卷期:2011年118-15]
- The National High Blood Pressure Education Program presents the complete Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Like its predecessors, t...
- Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome
[作者:Shao, BJ; Wahrenbrock, MG; Yao, LBA; David, T; Coughlin, SR; Xia, LJ; Varki, A; McEver, RP,期刊:Blood, 页码:4015-4023 , 文章类型: Article,,卷期:2011年118-15]
- Trousseau syndrome is classically defined as migratory, heparin-sensitive but warfarin-resistant microthrombi in patients with occult, mucinous adenocarcinomas. Injecting carcinoma mucins into mice generates platelet-ric...
- Evidence-based focused review of the treatment of idiopathic warm immune hemolytic anemia in adults
[作者:Crowther, M; Chan, YLT; Garbett, IK; Lim, W; Vickers, MA; Crowther, MA,期刊:Blood, 页码:4036-4040 , 文章类型: Review,,卷期:2011年118-15]
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- EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma
[作者:Kempf, W; Pfaltz, K; Vermeer, MH; Cozzio, A; Ortiz-Romero, PL; Bagot, M; Olsen, E; Kim, YH; Dummer, R; Pimpinelli, N; Whittaker, S; Hodak, E; Cerroni, L; Berti, E; Horwitz, S; Prince, HM; Guitart, J; Estrach, T; Sanches, JA; Duvic, M; Ranki, A; Dreno, B; Ostheeren-Michaelis, S; Knobler, R; Wood, G; Willemze, R,期刊:Blood, 页码:4024-4035 , 文章类型: Review,,卷期:2011年118-15]
- Primary cutaneous CD30(+) lymphoproliferative disorders (CD30(+) LPDs) are the second most common form of cutaneous T-cell lymphomas and include lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma...
- How I treat hemophagocytic lymphohistiocytosis
[作者:Jordan, MB; Allen, CE; Weitzman, S; Filipovich, AH; McClain, KL,期刊:Blood, 页码:4041-4052 , 文章类型: Article,,卷期:2011年118-15]
- Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation, occurring as either a familial disorder or a sporadic condition, in association with a variety of triggers. This immune dysregulator...
- Epratuzumab with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy in patients with previously untreated diffuse large B-cell lymphoma
[作者:Micallef, INM; Maurer, MJ; Wiseman, GA; Nikcevich, DA; Kurtin, PJ; Cannon, MW; Perez, DG; Soori, GS; Link, BK; Habermann, TM; Witzig, TE,期刊:Blood, 页码:4053-4061 , 文章类型: Article,,卷期:2011年118-15]
- Approximately 60% of patients with diffuse large B-cell non-Hodgkin lymphoma (DLBCL) are curable with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemoimmunotherapy. Epratuzumab (E) i...
- Risk of thyroid cancer, brain cancer, and non-Hodgkin lymphoma after adult leukemia: a nationwide study
[作者:Nielsen, SF; Bojesen, SE; Birgens, HS; Nordestgaard, BG,期刊:Blood, 页码:4062-4069 , 文章类型: Article,,卷期:2011年118-15]
- Patients with childhood leukemia surviving into adulthood have elevated risk of developing thyroid cancer, brain cancer, and non-Hodgkin lymphoma (NHL); these risks cannot automatically be extrapolated to patients surviv...
- Risk of acute myeloid leukemia and myelodysplastic syndromes after multiple myeloma and its precursor disease (MGUS)
[作者:Mailankody, S; Pfeiffer, RM; Kristinsson, SY; Korde, N; Bjorkholm, M; Goldin, LR; Turesson, I; Landgren, O,期刊:Blood, 页码:4086-4092 , 文章类型: Article,,卷期:2011年118-15]
- Using population-based data from Sweden, we identified all multiple myeloma (MM) patients (n = 8740) and 5652 monoclonal gammopathy of undetermined significance (MGUS) patients diagnosed between 1986 and 2005. We calcula...
- cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis
[作者:Zhang, YY; Jin, H; Li, L; Qin, FXF; Wen, ZL,期刊:Blood, 页码:4093-4101 , 文章类型: Article,,卷期:2011年118-15]
- The establishment of the HSC pool in vertebrates depends not only on the formation and the propagation of these stem cells but also on their proper trafficking among the defined hematopoietic organs. However, the physiol...
- A blood flow-dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos
[作者:Wang, L; Zhang, PP; Wei, YL; Gao, Y; Patient, R; Liu, F,期刊:Blood, 页码:4102-4110 , 文章类型: Article,,卷期:2011年118-15]
- Blood flow has long been thought to be important for vessel development and function, but its role in HSC development is not yet fully understood. Here, we take advantage of zebrafish embryos with circulation defects tha...
- Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation
[作者:Tacken, PJ; Ginter, W; Berod, L; Cruz, LJ; Joosten, B; Sparwasser, T; Figdor, CG; Cambi, A,期刊:Blood, 页码:4111-4119 , 文章类型: Article,,卷期:2011年118-15]
- Targeting antigens to dendritic cell (DC)specific receptors, such as DC-SIGN, induces potent T cell-mediated immune responses. DC-SIGN is a transmembrane C-type lectin receptor with a long extracellular neck region and a...
- Regulation of memory B-cell survival by the BH3-only protein Puma
[作者:Clybouw, C; Fischer, S; Auffredou, MT; Hugues, P; Alexia, C; Bouillet, P; Raphael, M; Leca, G; Strasser, A; Tarlinton, DM; Vazquez, A,期刊:Blood, 页码:4120-4128 , 文章类型: Article,,卷期:2011年118-15]
- Apoptosis is crucial for immune system homeostasis, including selection and survival of long-lived antibody-forming cells and memory cells. The interactions between proapoptotic and pro-survival proteins of the Bcl-2 fam...
- Hepcidin regulation by innate immune and infectious stimuli
[作者:Armitage, AE; Eddowes, LA; Gileadi, U; Cole, S; Spottiswoode, N; Selvakumar, TA; Ho, LP; Townsend, ARM; Drakesmith, H,期刊:Blood, 页码:4129-4139 , 文章类型: Article,,卷期:2011年118-15]
- Hepcidin controls the levels and distribution of iron, an element whose availability can influence the outcome of infections. We investigated hepcidin regulation by infection-associated cytokines, pathogen-derived molecu...
- HDM-2 inhibition suppresses expression of ribonucleotide reductase subunit M2, and synergistically enhances gemcitabine-induced cytotoxicity in mantle cell lymphoma
[作者:Jones, RJ; Baladandayuthapani, V; Neelapu, S; Fayad, LE; Romaguera, JE; Wang, M; Sharma, R; Yang, DJ; Orlowski, RZ,期刊:Blood, 页码:4140-4149 , 文章类型: Article,,卷期:2011年118-15]
- Mantle cell lymphoma (MCL) usually responds well to initial therapy but is prone to relapses with chemoresistant disease, indicating the need for novel therapeutic approaches. Inhibition of the p53 E3 ligase human homolo...
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