- Paracrine inhibition of GM-CSF signaling by human cytomegalovirus in monocytes differentiating to dendritic cells
[作者：Carlier, J; Martin, H; Mariame, B; Rauwel, B; Mengelle, C; Weclawiak, H; Coaquette, A; Vauchy, C; Rohrlich, P; Kamar, N; Rostaing, L; Herbein, G; Davrinche, C,期刊：Blood, 页码：6783-6792 , 文章类型： Article，,卷期：2011年118-26]
- A primary HCMV infection or virus reactivation may cause severe disease in hosts with a deficient immune system. The virus can disturb both innate and adaptive immunity by targeting dendritic cell (DC) functions. Monocyt...
- MicroRNA regulation of STAT4 protein expression: rapid and sensitive modulation of IL-12 signaling in human natural killer cells
[作者：Huang, Y; Lei, YF; Zhang, H; Hou, LC; Zhang, MJ; Dayton, AI,期刊：Blood, 页码：6793-6802 , 文章类型： Article，,卷期：2011年118-26]
- IL-12 exerts several regulatory effects on natural killer (NK) cells by activating IL-12 signaling. IL-12 signaling is tightly autoregulated to control its onset and termination, with prolonged IL-12 treatment resulting ...
- mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells
[作者：Smrz, D; Kim, MS; Zhang, SL; Mock, BA; Smrzova, S; DuBois, W; Simakova, O; Maric, I; Wilson, TM; Metcalfe, DD; Gilfillan, AM,期刊：Blood, 页码：6803-6813 , 文章类型： Article，,卷期：2011年118-26]
- Increased mast cell burden is observed in the inflamed tissues and affected organs and tissues of patients with mast cell proliferative disorders. However, normal mast cells participate in host defense, so approaches to ...
- B-cell replication history and somatic hypermutation status identify distinct pathophysiologic backgrounds in common variable immunodeficiency
[作者：Driessen, GJ; van Zelm, MC; van Hagen, PM; Hartwig, NG; Trip, M; Warris, A; de Vries, E; Barendregt, BH; Pico, I; Hop, W; van Dongen, JJM; van der Burg, M,期刊：Blood, 页码：6814-6823 , 文章类型： Article，,卷期：2011年118-26]
- Common variable immunodeficiency disorder (CVID) is the most prevalent form of primary idiopathic hypogammaglobulinemia. Identification of genetic defects in CVID is hampered by clinical and immunologic heterogeneity. By...
- IL-21 is the primary common gamma chain-binding cytokine required for human B-cell differentiation in vivo
[作者：Recher, M; Berglund, LJ; Avery, DT; Cowan, MJ; Gennery, AR; Smart, J; Peake, J; Wong, M; Pai, SY; Baxi, S; Walter, JE; Palendira, U; Tangye, GA; Rice, M; Brothers, S; Al-Herz, W; Oettgen, H; Eibel, H; Puck, JM; Cattaneo, F; Ziegler, JB; Giliani, S; Tangye, SG; Notarangelo, LD,期刊：Blood, 页码：6824-6835 , 文章类型： Article，,卷期：2011年118-26]
- SCID resulting from mutations in IL2RG or JAK3 is characterized by lack of T and natural killer cells; B cells are present in normal number, but antibody responses are defective. Hematopoietic cell transplantation (HCT) ...
- Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity
[作者：Tacken, PJ; Zeelenberg, IS; Cruz, LJ; van Hout-Kuijer, MA; van de Glind, G; Fokkink, RG; Lambeck, AJA; Figdor, CG,期刊：Blood, 页码：6836-6844 , 文章类型： Article，,卷期：2011年118-26]
- Effective vaccines consist of 2 components: immunodominant antigens and effective adjuvants. Whereas it has been demonstrated that targeted delivery of antigens to dendritic cells (DCs) improves vaccine efficacy, we repo...
- IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8(+) T effector memory population in peripheral blood
[作者：Sneller, MC; Kopp, WC; Engelke, KJ; Yovandich, JL; Creekmore, SP; Waldmann, TA; Lane, HC,期刊：Blood, 页码：6845-6848 , 文章类型： Article，,卷期：2011年118-26]
- IL-15 promotes activation and maintenance of natural killer (NK) and CD8(+) T effector memory (T(EM)) cells, making it a potential immunotherapeutic agent for the treatment of cancer and immunodeficiency states. Here we ...
- A shared gene expression signature in mouse models of EBV-associated and non-EBV-associated Burkitt lymphoma
[作者：Bieging, KT; Fish, K; Bondada, S; Longnecker, R,期刊：Blood, 页码：6849-6859 , 文章类型： Article，,卷期：2011年118-26]
- The link between EBV infection and Burkitt lymphoma (BL) is strong, but the mechanism underlying that link has been elusive. We have developed a mouse model for EBV-associated BL in which LMP2A, an EBV latency protein, a...
- Etv2/ER71 induces vascular mesoderm from Flk1(+)PDGFR alpha(+) primitive mesoderm
[作者：Kataoka, H; Hayashi, M; Nakagawa, R; Tanaka, Y; Izumi, N; Nishikawa, S; Jakt, ML; Tarui, H; Nishikawa, SI,期刊：Blood, 页码：6975-6986 , 文章类型： Article，,卷期：2011年118-26]
- Etv2 (Ets Variant 2) has been shown to be an indispensable gene for the development of hematopoietic cells (HPCs)/endothelial cells (ECs). However, how Etv2 specifies the mesoderm-generating HPCs/ECs remains incompletely...
- Transcriptomic analyses of murine resolution-phase macrophages
[作者：Stables, MJ; Shah, S; Camon, EB; Lovering, RC; Newson, J; Bystrom, J; Farrow, S; Gilroy, DW,期刊：Blood, 页码：E192-E208 , 文章类型： Article，,卷期：2011年118-26]
- Macrophages are either classically (M1) or alternatively-activated (M2). Whereas this nomenclature was generated from monocyte-derived macrophages treated in vitro with defined cytokine stimuli, the phenotype of in vivo-...
- Defining the role of TORC1/2 in multiple myeloma
[作者：Maiso, P; Liu, Y; Morgan, B; Azab, AK; Ren, PD; Martin, MB; Zhang, Y; Liu, Y; Sacco, A; Ngo, H; Azab, F; Quang, P; Rodig, SJ; Lin, CP; Roccaro, AM; Rommel, C; Ghobrial, IM,期刊：Blood, 页码：6860-6870 , 文章类型： Article，,卷期：2011年118-26]
- Mammalian target of rapamycin (mTOR) is a downstream serine/threonine kinase of the PI3K/Akt pathway that integrates signals from the tumor microenvironment to regulate multiple cellular processes. Rapamycin and its anal...
- Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease
[作者：D'Souza, S; del Prete, D; Jin, SQ; Sun, QH; Huston, AJ; Kostov, FE; Sammut, B; Hong, CS; Anderson, JL; Patrene, KD; Yu, SB; Velu, CS; Xiao, GZ; Grimes, HL; Roodman, GD; Galson, DL,期刊：Blood, 页码：6871-6880 , 文章类型： Article，,卷期：2011年118-26]
- Protracted inhibition of osteoblast (OB) differentiation characterizes multiple myeloma (MM) bone disease and persists even when patients are in long-term remission. However, the underlying pathophysiology for this prolo...
- miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma
[作者：Matsuyama, H; Suzuki, HI; Nishimori, H; Noguchi, M; Yao, T; Komatsu, N; Mano, H; Sugimoto, K; Miyazono, K,期刊：Blood, 页码：6881-6892 , 文章类型： Article，,卷期：2011年118-26]
- Many transformed lymphoma cells show immune-phenotypes resembling the corresponding normal lymphocytes; thus, they provide a guide for proper diagnosis and present promising routes to improve their pathophysiologic under...
- FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death
[作者：Alinari, L; Mahoney, E; Patton, J; Zhang, XL; Huynh, L; Earl, CT; Mani, R; Mao, YC; Yu, B; Quinion, C; Towns, WH; Chen, CS; Goldenberg, DM; Blum, KA; Byrd, JC; Muthusamy, N; Praetorius-Ibba, M; Baiocchi, RA,期刊：Blood, 页码：6893-6903 , 文章类型： Article，,卷期：2011年118-26]
- Mantle cell lymphoma (MCL) is an aggressive B-cell malignancy with a short median survival despite multimodal therapy. FTY720, an immunosuppressive drug approved for the treatment of multiple sclerosis, promotes MCL cell...
- Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness
[作者：Rossi, D; Bruscaggin, A; Spina, V; Rasi, S; Khiabanian, H; Messina, M; Fangazio, M; Vaisitti, T; Monti, S; Chiaretti, S; Guarini, A; Del Giudice, I; Cerri, M; Cresta, S; Deambrogi, C; Gargiulo, E; Gattei, V; Forconi, F; Bertoni, F; Deaglio, S; Rabadan, R; Pasqualucci, L; Foa, R; Dalla-Favera, R; Gaidano, G,期刊：Blood, 页码：6904-6908 , 文章类型： Article，,卷期：2011年118-26]
- The genetic lesions identified in chronic lymphocytic leukemia (CLL) do not entirely recapitulate the disease pathogenesis and the development of serious complications, such as chemorefractoriness. While investigating th...
- Delta(12)-prostaglandin J(3), an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
[作者：Hegde, S; Kaushal, N; Ravindra, KC; Chiaro, C; Hafer, KT; Gandhi, UH; Thompson, JT; van den Heuvel, JP; Kennett, MJ; Hankey, P; Paulson, RF; Prabhu, KS,期刊：Blood, 页码：6909-6919 , 文章类型： Article，,卷期：2011年118-26]
- Targeting cancer stem cells is of paramount importance in successfully preventing cancer relapse. Recently, in silico screening of public gene-expression data-sets identified cyclooxygenase-derived cyclopentenone prostag...
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