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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共45条记录   N-Acetyl lysyl-tRNA synthetases evolved by a CcdB-based selection possess N-acetyl lysine specificity in vitro and in vivo [作者：Umehara, T; Kim, J; Lee, S; Guo, LT; Soll, D; Park, HS,期刊：FEBS Letters, 页码：729-733 , 文章类型： Article，,卷期：2012年586-6] Posttranslational modifications play a crucial role in modulating protein structure and function. Genetic incorporation of unnatural amino acids into a specific site of a protein facilitates the systematic study of prote... Crystal structure of a single-chain trimer of human adiponectin globular domain [作者：Min, XS; Lemon, B; Tang, J; Liu, Q; Zhang, R; Walker, N; Li, Y; Wang, ZL,期刊：FEBS Letters, 页码：912-917 , 文章类型： Article，,卷期：2012年586-6] Adiponectin is increasingly recognized as a potential therapeutic agent for the treatment of diabetes and other metabolic diseases. It circulates in plasma as homotrimers and higher-order oliogomers of homotrimers. To fa... Crystal structure of Cmr2 suggests a nucleotide cyclase-related enzyme in type III CRISPR-Cas systems [作者：Zhu, X; Ye, KQ,期刊：FEBS Letters, 页码：939-945 , 文章类型： Article，,卷期：2012年586-6] CRISPR RNAs (crRNAs) mediate sequence-specific silencing of invading viruses and plasmids in prokaryotes. The crRNA-Cmr protein complex cleaves complementary RNA. We report the crystal structure of Pyrococcus furiosus Cm... Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6 [作者：Cai, Y; Yu, SS; Chen, SR; Pi, RBA; Gao, S; Li, H; Ye, JT; Liu, PQ,期刊：FEBS Letters, 页码：866-874 , 文章类型： Article，,卷期：2012年586-6] The discovery of sirtuins (SIRT), a family of nicotinamide adenine dinucleotide (NAD)-dependent deacetylases, has indicated that intracellular NAD level is crucial for the hypertrophic response of cardiomyocytes. Nicotin... OIT3 deficiency impairs uric acid reabsorption in renal tubule [作者：Yan, B; Zhang, ZZ; Huang, LY; Shen, HL; Han, ZG,期刊：FEBS Letters, 页码：760-765 , 文章类型： Article，,卷期：2012年586-6] The oncoprotein induced transcript 3 (OIT3), also named liver-specific zona pellucida domain-containing protein (LZP), has been shown to be expressed in kidney, and was confirmed to interact with the Tamm-Horsfall glycop... Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins [作者：Adams-Cioaba, MA; Li, ZH; Tempel, W; Guo, YH; Bian, CB; Li, YJ; Lam, R; Min, JR,期刊：FEBS Letters, 页码：859-865 , 文章类型： Article，,卷期：2012年586-6] The human PHD finger protein 20 (PHF20) is a putative transcription factor. While little is known about its cognate cellular role, antibodies against PHF20 are present in sera from patients with hepatocellular carcinoma,... Overexpression of lalA, a paralog of labA, is capable of affecting both circadian gene expression and cell growth in the cyanobacterium Synechococcus elongatus PCC 7942 [作者：Taniguchi, Y; Nishikawa, T; Kondo, T; Oyama, T,期刊：FEBS Letters, 页码：753-759 , 文章类型： Article，,卷期：2012年586-6] In the cyanobacterium Synechococcus elongatus, LabA negatively regulates circadian gene expression under the control of Kai-protein-based clock. Here we conducted a molecular genetic analysis of lalA, a paralog of labA. ... Prediction of replication origins by calculating DNA structural properties [作者：Chen, W; Feng, PMA; Lin, H,期刊：FEBS Letters, 页码：934-938 , 文章类型： Article，,卷期：2012年586-6] In this study, we introduced two DNA structural characteristics, namely, bendability and hydroxyl radical cleavage intensity to analyze origin of replication (ORI) in the Saccharomyces cerevisiae genome. We found that bo... Pro(42) and Val(45) of staphylokinase modulate intermolecular interactions of His(43)-Tyr(44) pair and specificity of staphylokinase-plasmin activator complex [作者：Singh, S; Ashish; Dikshit, KL,期刊：FEBS Letters, 页码：653-658 , 文章类型： Article，,卷期：2012年586-6] Staphylokinase (SAK) forms a 1:1 stoichiometric complex with plasmin (Pm) and changes its substrate specificity to create a plasminogen (Pg) activator complex. The His(43)-Tyr(44) pair of SAK resides within the active si... Rational design of DNA sequence-specific zinc fingers [作者：Kono, H; Imanishi, M; Negi, S; Tatsutani, K; Sakaeda, Y; Hashimoto, A; Nakayama, C; Futaki, S; Sugiura, Y,期刊：FEBS Letters, 页码：918-923 , 文章类型： Article，,卷期：2012年586-6] We developed a rational scheme for designing DNA binding proteins. The scheme was applied for a zinc finger protein and the designed sequences were experimentally characterized with high DNA sequence specificity. Startin... Formation of amyloid fibrils from beta-amylase [作者：Luo, JC; Wang, SC; Jian, WB; Chen, CH; Tang, JL; Lee, CI,期刊：FEBS Letters, 页码：680-685 , 文章类型： Article，,卷期：2012年586-6] Fibril formation has been considered a significant feature of amyloid proteins. However, it has been proposed that fibril formation is a common property of many proteins under appropriate conditions. We studied the fibri... Requirement for Pak3 in Rac1-induced organization of actin and myosin during Drosophila larval wound healing [作者：Baek, SH; Cho, HW; Kwon, YC; Lee, JH; Kim, MJ; Lee, H; Choe, KM,期刊：FEBS Letters, 页码：772-777 , 文章类型： Article，,卷期：2012年586-6] Rho-family small GTPases regulate epithelial cell sheet migration by organizing actin and myosin during wound healing. Here, we report that Pak3, but not Pak1, is a downstream target protein for Rac1 in wound closure of ... GSH threshold requirement for NO-mediated expression of the Arabidopsis AtFer1 ferritin gene in response to iron [作者：Touraine, B; Briat, JF; Gaymard, F,期刊：FEBS Letters, 页码：880-883 , 文章类型： Article，,卷期：2012年586-6] Iron treatment of Arabidopsis cultured cells promotes a rapid NO burst within chloroplasts, necessary for up-regulation of the AtFer1 ferritin gene expression. The same occurs in Arabidopsis leaf chloroplasts, and is dep... HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-kappa B signaling to protect breast cancer cells from complement attack [作者：Cui, WJ; Zhao, Y; Shan, CL; Kong, GY; Hu, N; Zhang, YW; Zhang, S; Zhang, WY; Zhang, YY; Zhang, XD; Ye, LH,期刊：FEBS Letters, 页码：766-771 , 文章类型： Article，,卷期：2012年586-6] Hepatitis B X-interacting protein (HBXIP) is able to enhance migration of breast cancer cells. However, the role of HBXIP in regulation of complement-dependent cytotoxicity (CDC) in breast cancer is not understood. Here,... Scythe cleavage during Fas (APO-1)-and staurosporine-mediated apoptosis [作者：Preta, G; Fadeel, B,期刊：FEBS Letters, 页码：747-752 , 文章类型： Article，,卷期：2012年586-6] Scythe is a nuclear protein that has been implicated in the apoptotic process in Drosophila melanogaster; however, its role in apoptosis of mammalian cells is not fully elucidated. Here we show that cleavage of Scythe by... Selenomodification of tRNA in archaea requires a bipartite rhodanese enzyme [作者：Su, D; Ojo, TT; Soll, D; Hohn, MJ,期刊：FEBS Letters, 页码：717-721 , 文章类型： Article，,卷期：2012年586-6] 5-Methylaminomethyl-2-selenouridine (mnm(5)Se(2)U) is found in the first position of the anticodon in certain tRNAs from bacteria, archaea and eukaryotes. This selenonucleoside is formed in Escherichia coli from the corr...