- Design, synthesis and evaluation of 4,7-diamino-1,10-phenanthroline G-quadruplex ligands
[作者:NIELSEN MADS CORVINIUS; BORCH JONAS; ULVEN TROND,期刊:Bioorganic & Medicinal Chemistry, 页码:8241-8246 , 文章类型: Article,,卷期:2009年17-24]
- A series of 4,7-diamino-1,10-phenanthroline derivatives carrying positively charged side chains has been synthesized, and their G-quadruplex interaction evaluated by circular dichroism (CD) and surface plasmon resonance ...
- Optimization of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin V-2 receptor agonists and discussion of their binding modes
[作者:TSUKAMOTO ISSEI; KOSHIO HIROYUKI; ORITA MASAYA; SAITOH CHIKASHI; YANAIINAMURA HIROKO; KITADANOZAWA CHIKA; YAMAMOTO EISAKU; YATSU TAKEYUKI; SAKAMOTO SHUICHI; TSUKAMOTO SHINICHI,期刊:Bioorganic & Medicinal Chemistry, 页码:8161-8167 , 文章类型: Article,,卷期:2009年17-24]
- A series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives were optimized to achieve potent agonistic activity, both in vitro and in vivo, for the arginine vasopressin V-2 receptor, res...
- Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: Exploration of 6-6 fused rings as alternative S1 moieties
[作者:YOSHIKAWA KENJI; KOBAYASHI SHOZO; NAKAMOTO YUMI; HAGINOYA NORIYASU; KOMORIYA SATOSHI; YOSHINO TOSHIHARU; NAGATA TSUTOMU; MOCHIZUKI AKIYOSHI; WATANABE KENGO; SUZUKI MAKOTO; KANNO HIDEYUKI; OHTA TOSHIHARU,期刊:Bioorganic & Medicinal Chemistry, 页码:8221-8233 , 文章类型: Article,,卷期:2009年17-24]
- A series of cis-1,2-diaminocyclohexane derivatives possessing a 6-6 fused ring for the S1 moiety were synthesized as novel factor Xa (fXa) inhibitors. The synthesis, structure-activity relationship (SAR), and physicochem...
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