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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共33条记录   Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans [作者：Halperin, F; Lopez, X; Manning, R; Kahn, CR; Kullcarni, RN; Goldfine, AB,期刊：Diabetes, 页码：301-309 , 文章类型： Article，,卷期：2012年61-2] Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic beta-cell dysfunction, the latter possibly caused by a defect in insulin signaling in beta-cells. We hypothesized that insulin's effect to poten... Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice [作者：Attane, C; Foussal, C; Le Gonidec, S; Benani, A; Daviaud, D; Wanecq, E; Guzman-Ruiz, R; Dray, C; Bezaire, V; Rancoule, C; Kuba, K; Ruiz-Gayo, M; Levade, T; Penninger, J; Burcelin, R; Penicaud, L; Valet, P; Castan-Laurell, I,期刊：Diabetes, 页码：310-320 , 文章类型： Article，,卷期：2012年61-2] Both acute and chronic apelin treatment have been shown to improve insulin sensitivity in mice. However, the effects of apelin on fatty acid oxidation (FAO) during obesity-related insulin resistance have not yet been add... Brain Glucose Sensors Play a Significant Role in the Regulation of Pancreatic Glucose-Stimulated Insulin Secretion [作者：Osundiji, MA; Lam, DD; Shaw, J; Yueh, CY; Markkula, SP; Hurst, P; Colliva, C; Roda, A; Heisler, LK; Evans, ML,期刊：Diabetes, 页码：321-328 , 文章类型： Article，,卷期：2012年61-2] As patients decline from health to type 2 diabetes, glucose-stimulated insulin secretion (GSIS) typically becomes impaired. Although GSIS is driven predominantly by direct sensing of a rise in blood glucose by pancreatic... Storage Rates of Circulating Free Fatty Acid Into Adipose Tissue During Eating or Walking in Humans [作者：Koutsari, C; Mundi, MS; Ali, AH; Jensen, MD,期刊：Diabetes, 页码：329-338 , 文章类型： Article，,卷期：2012年61-2] We measured subcutaneous adipose tissue free fatty acid (FFA) storage rates in postprandial and walking conditions to better understand the contributions of this pathway to body fat distribution. Palmitate tracers were i... Glucocorticoid Signaling in the Arcuate Nucleus Modulates Hepatic Insulin Sensitivity [作者：Yi, CX; Foppen, E; Abplanalp, W; Gao, YQ; Alkemade, A; la Fleur, SE; Serlie, MJ; Fliers, E; Buijs, RM; Tschop, MH; Kalsbeek, A,期刊：Diabetes, 页码：339-345 , 文章类型： Article，,卷期：2012年61-2] Glucocorticoid receptors are highly expressed in the hypothalamic paraventricular nucleus (PVN) and arcuate nucleus (ARC). As glucocorticoids have pronounced effects on neuropeptide Y (NPY) expression and as NPY neurons ... Increased Macrophage Migration Into Adipose Tissue in Obese Mice [作者：Oh, DY; Morinaga, H; Talukdar, S; Bae, EJ; Olefsky, JM,期刊：Diabetes, 页码：346-354 , 文章类型： Article，,卷期：2012年61-2] Macrophage-mediated inflammation is a key component of insulin resistance; however, the initial events of monocyte migration to become tissue macrophages remain poorly understood. We report a new method to quantitate in ... CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action [作者：Lord, CC; Betters, JL; Ivanova, PT; Milne, SB; Myers, DS; Madenspacher, J; Thomas, G; Chung, S; Liu, MX; Davis, MA; Lee, RG; Crooke, RM; Graham, MJ; Parks, JS; Brasaemle, DL; Fessler, MB; Brown, HA; Brown, JM,期刊：Diabetes, 页码：355-363 , 文章类型： Article，,卷期：2012年61-2] Mutations of comparative gene identification 58 (CGI-58) in humans cause Chanarin-Dorfman syndrome, a rare autosomal recessive disease in which excess triacylglycerol (TAG) accumulates in multiple tissues. CGI-58 recentl... Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2 [作者：Tolhurst, G; Heffron, H; Lam, YS; Parker, HE; Habib, AM; Diakogiannaki, E; Cameron, J; Grosse, J; Reimann, F; Gribble, FM,期刊：Diabetes, 页码：364-371 , 文章类型： Article，,卷期：2012年61-2] Interest in how the gut microbiome can influence the metabolic state of the host has recently heightened. One postulated link is bacterial fermentation of "indigestible" prebiotics to short-chain fatty acids (SCFAs), whi... Potential Role of Tumor Necrosis Factor-alpha in Downregulating Sex Hormone-Binding Globulin [作者：Simo, R; Barbosa-Desongles, A; Lecube, A; Hernandez, C; Selva, DM,期刊：Diabetes, 页码：372-382 , 文章类型： Article，,卷期：2012年61-2] Low plasma sex hormone-binding globulin (SHBG) levels are associated with obesity and predict the development of type 2 diabetes. The reason why obese individuals have low circulating SHBG has been attributed to hyperins... Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity [作者：Creemers, JWM; Choquet, H; Stijnen, P; Vatin, V; Pigeyre, M; Beckers, S; Meulemans, S; Than, ME; Yengo, L; Tauber, M; Balkan, B; Elliott, P; Jarvelin, MR; Van Hul, W; Van Gaal, L; Horber, F; Pattou, F; Froguel, P; Meyre, D,期刊：Diabetes, 页码：383-390 , 文章类型： Article，,卷期：2012年61-2] Null mutations in the PCSK1 gene, encoding the proprotein convertase 1/3 (PC1/3), cause recessive monogenic early onset obesity. Frequent coding variants that modestly impair PC1/3 function mildly increase the risk for c... Postnatal Growth and DNA Methylation Are Associated With Differential Gene Expression of the TACSTD2 Gene and Childhood Fat Mass [作者：Groom, A; Potter, C; Swan, DC; Fatemifar, G; Evans, DM; Ring, SM; Turcot, V; Pearce, MS; Embleton, ND; Smith, GD; Mathers, JC; Relton, CL,期刊：Diabetes, 页码：391-400 , 文章类型： Article，,卷期：2012年61-2] Rapid postnatal growth is associated with increased risk of childhood adiposity. The aim of this study was to establish whether this pathway is mediated by altered DNA methylation and gene expression. Two distinct cohort... Morbidly Obese Human Subjects Have Increased Peripheral Blood CD4(+) T Cells With Skewing Toward a Treg- and Th2-Dominated Phenotype [作者：van der Weerd, K; Dik, WA; Schrijver, B; Schweitzer, DH; Langerak, AW; Drexhage, HA; Kiewiet, RM; van Aken, MO; van Huisstede, A; van Dongen, JJM; van der Lelij, AJ; Staal, FJT; van Hagen, PM,期刊：Diabetes, 页码：401-408 , 文章类型： Article，,卷期：2012年61-2] Obesity is associated with local T-cell abnormalities in adipose tissue. Systemic obesity-related abnormalities in the peripheral blood T-cell compartment are not well defined. In this study, we investigated the peripher... L-Leucine Alters Pancreatic beta-Cell Differentiation and Function via the mTor Signaling Pathway [作者：Rachdi, L; Aiello, V; Duvillie, B; Scharfmann, R,期刊：Diabetes, 页码：409-417 , 文章类型： Article，,卷期：2012年61-2] Leucine (Leu) is an essential branched-chain amino acid, which activates the mammalian target of rapamycin (mTOR) signaling pathway. The effect of Leu on cell differentiation during embryonic development is unknown. Here... Regulated and Reversible Induction of Adult Human beta-Cell Replication [作者：Takane, KK; Kleinberger, JW; Salim, FG; Fiaschi-Taesch, NM; Stewart, AF,期刊：Diabetes, 页码：418-424 , 文章类型： Article，,卷期：2012年61-2] Induction of proliferation in adult human beta-cells is challenging. It can be accomplished by introduction of cell cycle molecules such as cyclin-dependent kinase 6 (cdk6) and cyclin D(1), but their continuous overexpre... Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells [作者：Krishnamurthy, B; Chee, J; Jhala, G; Fynch, S; Graham, KL; Santamaria, P; Morahan, G; Allison, J; Izon, D; Thomas, HE; Kay, TWH,期刊：Diabetes, 页码：425-435 , 文章类型： Article，,卷期：2012年61-2] Prevention of autoimmunity requires the elimination of self-reactive T cells during their development in the thymus and maturation in the periphery. Transgenic NOD mice that over-express islet-specific glucose 6 phosphat... Expression and Regulation of Chemoldnes in Murine and Human Type 1 Diabetes [作者：Sarkar, SA; Lee, CE; Victorino, F; Nguyen, TT; Walters, JA; Burrack, A; Eberlein, J; Hildemann, SK; Homann, D,期刊：Diabetes, 页码：436-446 , 文章类型： Article，,卷期：2012年61-2] More than one-half of the similar to 50 human chemokines have been associated with or implicated in the pathogenesis of type 1 diabetes, yet their actual expression patterns in the islet environment of type 1 diabetic pa...